User:Hong-Wu Chen

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Contact Info

Hong-Wu Chen

  • Hong-Wu Chen, Ph.D.
  • Professor
  • Department of Biochemistry & Molecular Medicine, UC Davis School of Medicine*[|Biochemistry & Mol Med]
  • Research III Bldg, Room 1400B
  • 4645 2nd Ave
  • Sacramento, CA 95817, the United State
  • Email: hwzchen@ucdavis.edu
  • My Laboratory Website


Education

  • Year, PhD, Institute
  • Year, MS, Institute
  • Year, BS, Institute

Research interests

Our current research focuses are the followings:

  1. Exploring nuclear receptor (NR) sub-family members, such as the retinoid receptor-related receptors (RORs)/NR1Fs, as novel therapeutic targets for advanced cancers (e.g. mCRPC);
  2. Exploring key epigenetic regulators including the histone demethylases (e.g. KDM4s) and bromodomain proteins (e.g. ANCCA/ATAD2) as novel therapeutic targets for cancer;
  3. Elucidating the functional mechanisms of key epigenetic regulators and nuclear receptors in tumorigenesis and therapeutic resistance;
  4. Developing biomarkers for guiding effective targeted therapies.

Publications

Publications in 2016

  • Wang J, Wang H, Wang L, Cai D, Duan Z, Chen P, Zou JX, Xu J, Kung H-J, and Chen H-W. Silencing the epigenetic silencer KDM4A for TRAIL and DR5 induction and antitumor therapy. Cell Death & Differentiation. 2016, In Press.[[1]]


  • Wang J, Zou JX, Xue X, Cai D, Zhang Y, Duan Z, Xiang Q, Yang JC, Louie MC, Borowsky AD, Gao AC, Evans CP, Lam KS, Xu J, Kung HJ, Evans RM, Xu Y, Chen HW. ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. Nature Medicine. 2016 May;22(5):488-96. doi: 10.1038/nm.4070. Epub 2016 Mar 28. PMID: 27019329.[[2]]


  • Wang J, Duan Z, Nugent Z, Zou JX, Borowsky AD, Zhang Y, Tepper CG, Li JJ, Fienh O, Xu J, Kung HJ, Murphy L, Chen HW. Reprogramming metabolism by histone methyltransferase NSD2 drives endocrine resistance via coordinated activation of pentose phosphate pathway enzymes. Cancer Lett. 2016 May 6;378(2):69-79. doi: 10.1016/j.canlet.2016.05.004. [Epub ahead of print], PMID: 27164560[[3]]


  • Chen P, Wang H, Yang F, Chen HW, He W, Wang J. Curcumin Promotes Osteosarcoma Cell Death by Activating miR-125a/ERRα Signal Pathway. J Cell Biochem. 2016 May 27. doi: 10.1002/jcb.25612. PMID: 27231954[[4]]


  • Huang J, Yang J, Lei Y, Gao H, Wei T, Luo L, Zhang F, Chen HW, Zeng Q, Guo L. An ANCCA/PRO2000-miR-520a-E2F2 regulatory loop as a driving force for the development of hepatocellular carcinoma. Oncogenesis. 2016 May 30;5(5):e229. doi: 10.1038/oncsis.2016.22. PMID: 27239961[[5]]


Selected Publications before 2016

  • Chen HW, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y, Evans RM. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell. 1997 Aug 8;90(3):569-580. PMID: 9267036[[6]]


  • Chen HW, Lin RJ, Xie W, Wilpitz D, Evans RM. Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase. Cell. 1999 Sep 3;98(5):675-686. PMID: 10490106[[7]]


  • Xu W, Chen H, Du K, Asahara H, Tini M, Emerson BM, Montminy M, Evans RM. A transcriptional switch mediated by cofactor methylation. Science. 2001 Dec 21;294(5551):2507-11. PMID: 11701890[[8]]


  • Xia Y, Pao GM, Chen HW, Verma IM, Hunter T. Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein. J Biol Chem. 2003 Feb 14;278(7):5255-63. PMID: 12431996[[9]]


  • Louie MC, Yang HQ, Ma AH, Xu W, Zou JX, Kung HJ, Chen HW. Androgen-induced recruitment of RNA polymerase II to a nuclear receptor-p160 coactivator complex. Proc Natl Acad Sci USA. 2003 Mar 4;100(5):2226-30.[[10]]


  • Levy AM, Izumiya Y, Brunovskis P, Xia L, Parcells MS, Reddy SM, Lee L, Chen HW, Kung HJ. Characterization of the chromosomal binding sites and dimerization partners of the viral oncoprotein Meq in Marek's disease virus-transformed T cells. J Virol. 2003 Dec;77(23):12841-51.[[11]]


  • Lee LF, Louie MC, Desai SJ, Yang J, Chen HW, Evans CP, Kung HJ. Interleukin-8 confers androgen-independent growth and migration of LNCaP: differential effects of tyrosine kinases Src and FAK. Oncogene. 2004 Feb 9; 23, 2197-2205.[[12]]


  • Louie MC, Zou JX, Rabinovich A, Chen HW. ACTR/AIB1 functions as an E2F1 coactivator to promote breast cancer cell proliferation and anti-estrogen resistance. Mol. Cell. Biol. 2004, 24(12):5157-5171.[[13]]


  • Louie MC, Revenko AS, Zou JX, Yao J, Chen HW. Direct control of cell cycle gene expression by proto-oncogene ACTR, and its auto-regulation underlies its transforming activity. Mol. Cell. Biol. 2006, 26(10):3810-3823.[[14]]


  • Zou JX, Zhong Z, Shi XB, Tepper CG, deVere White RW, Kung HJ, Chen HW. ACTR/AIB1/SRC-3 and androgen receptor control prostate cancer cell proliferation and tumor growth through direct control of cell cycle genes. Prostate. 2006, 66(14):1474-86.[[15]]


  • Ma AH, Xia L, Desai SJ, Boucher DL, Guan Y, Shih HM, Shi XB, Devere White RW, Chen HW, Tepper CG, Kung HJ. Male Germ Cell-Associated Kinase, a Male-Specific Kinase Regulated by Androgen, Is a Coactivator of Androgen Receptor in Prostate Cancer Cells. Cancer Res. 2006, 66(17):8439-8447.[[16]]


  • Desai SJ, Ma AH, Tepper CG, Chen HW, Kung HJ. Inappropriate activation of the androgen receptor by nonsteroids: involvement of the Src kinase pathway and its therapeutic implications. Cancer Res. 2006 Nov 1;66(21):10449-59.[[17]]


  • Zou JX, Revenko AS, Li LB, Gemo AT, Chen HW. ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ER{alpha}, is required for coregulator occupancy and chromatin modification. Proc Natl Acad Sci USA. 2007 Nov 13;104(46):18067-18072.[[18]]


  • Li LB, Louie MC, Chen HW, Zou JX. Proto-oncogene ACTR/AIB1 promotes cancer cell invasion by up-regulating specific matrix metalloproteinase expression. Cancer Lett. 2008 Mar 8;261(1):64-73.[[19]]


  • Shi XB, Xue L, Zou JX, Gandour-Edwards R, Chen HW, de Vere White RW. Prolonged androgen receptor loading onto chromatin and the efficient recruitment of p160 coactivators contribute to androgen-independent growth of prostate cancer cells. Prostate. 2008 Sep 8;68(16):1816-1826.[[20]]


  • Qin L, Liao L, Redmond A, Young L, Yuan Y, Chen HW, O'Malley BW, Xu J. The AIB1 oncogene promotes breast cancer metastasis by activation of PEA3-mediated matrix metalloproteinase 2 (MMP2) and MMP9 expression. Mol Cell Biol. 2008 Oct; 28(19):5937-50.[[21]]


  • Zou JX, Guo L, Revenko AS, Tepper CG, Gemo AT, Kung HJ, Chen HW. Androgen-induced coactivator ANCCA mediates specific androgen receptor signaling in prostate cancer. Cancer Res. 2009 April 15:69 (8):3339-46.[[22]]


  • Qin L, Liu Z, HW Chen, Xu J. The Steroid Receptor Coactivator-1 (SRC-1) Regulates Twist Expression and Promotes Breast Cancer Metastasis. Cancer Res. 2009 May 1;69 (9):3819-27.[[23]]


  • Hsia EY, Zou JX, and Chen HW. The Roles and Action Mechanisms of p160/SRC Coactivators and the ANCCA Coregulator in Cancer. In Progress in Molecular Biology and Translational Science, Volume 87, (Ed. Chakravarti, D), Academic Press, 2009, pp.261-298.[[24]]


  • Hsia EY, Kalashnikova EV, Revenko AS, Zou JX, Borowsky AD, Chen HW. Deregulated E2F and the AAA+ coregulator ANCCA drive proto-oncogene ACTR/AIB1 overexpression in breast cancer. Mol Cancer Res. 2010 Feb;8(2):183-93. Epub 2010 Feb 2[[25]]


  • Hsia DA, Tepper CG, Pochampalli MR, Hsia EY, Izumiya C, Huerta SB, Wright ME, Chen HW, Kung HJ, Izumiya Y. KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation. Proc Natl Acad Sci USA. 2010 May 25;107(21):9671-6.[[26]]


  • Kalashnikova EV, Revenko AS, Gemo AT, Andrews NP, Tepper CG, Zou JX, Cardiff RD, Borowsky AD, Chen HW. ANCCA/ATAD2 Overexpression Identifies Breast Cancer Patients with Poor Prognosis, Acting to Drive Proliferation and Survival of Triple-Negative Cells through Control of B-Myb and EZH2. Cancer Res. 2010 Nov 15;70(22):9402-12.[[27]]


  • Revenko AS, Kalashnikova EV, Gemo AT, Zou JX, Chen HW. Chromatin loading of E2F-MLL complex by cancer-associated coregulator ANCCA via reading a specific histone mark. Mol Cell Biol. 2010 Nov;30(22):5260-72.[[28]]


  • Hsia EY, Goodson ML, Zou JX, Privalsky ML, Chen HW. Nuclear receptor coregulators as a new paradigm for therapeutic targeting. Adv Drug Deliv Rev. 2010 Oct 7. 62: 1227–1237.[[29]]


  • Zhang J, Cho SJ, Shu L, Yan W, Guerrero T, Kent M, Skorupski K, Chen HW, Chen X. Translational repression of p53 by RNPC1, a p53 target overexpressed in lymphomas. Genes Dev. 2011 Jul 15;25(14):1528-43[[30]]


  • Yang P, Guo L, Duan ZJ, Tepper CG, Xue L, Chen X, Kung HJ, Gao AC, Zou JX, Chen HW. Histone methyltransferase NSD2/MMSET mediates constitutive NF-κB signaling for cancer cell proliferation, survival, and tumor growth via a feed-forward loop. Mol Cell Biol. 2012 Aug;32(15):3121-31. PMID:22645312 [[31]]


  • Nadiminty N, Tummala R, Lou W, Zhu Y, Shi XB, Zou JX, Chen HW, Zhang J, Chen X, Luo J, deVere White RW, Kung HJ, Evans CP, Gao AC. MicroRNA let-7c is downregulated in prostate cancer and suppresses prostate cancer growth. PLoS One. 2012;7(3):e32832. PMID:22479342[[32]]


  • Berger CE, Qian Y, Liu G, Chen HW, Chen X. p53, a target of estrogen receptor (ER) α, modulates DNA damage-induced growth suppression in ER-positive breast cancer cells. J Biol Chem. 2012 Aug 31;287(36):30117-27.PMID:22787161. [[33]]


  • Duan Z, Zou JX, Yang P, Wang Y, Borowsky AD, Gao AC, Chen HW. Developmental and androgenic regulation of chromatin regulators EZH2 and ANCCA/ATAD2 in the prostate Via MLL histone methylase complex. Prostate. 2013 Apr; 73(5)455-66. doi: 10.1002/pros.22587. PMID:23038103. [[34]]


  • Tummala R, Nadiminty N, Lou W, Zhu Y, Gandour-Edwards R, Chen HW, Evans CP, Gao AC. Lin28 promotes growth of prostate cancer cells and activates the androgen receptor. Am J Pathol. 2013 Jul;183(1):288-95. PMID:23790802. [[35]]


  • Chen NT, Kuwabara Y, Conley C, Liao YC, Hong SY, Chen M, Shih YP, Chen HW, Hsieh F, Lo SH. Phylogenetic analysis, expression patterns, and transcriptional regulation of human CTEN gene. Gene. 2013 May 15;520(2):90-7. PMID:23500447 [[36]]


  • Gan Q, Lee A, Suzuki R, Yamagami T, Stokes A, Nguyen BC, Pleasure D, Wang J, Chen HW, Zhou CJ. Pax6 mediates ß-catenin signaling for self-renewal and neurogenesis by neocortical radial glial stem cells. Stem Cells. 2014 Jan;32(1):45-58. doi: 10.1002/stem.1561. PMID:24115331 [[37]]


  • Zou JX, Duan Z, Wang J, Sokolov A, Xu J, Chen CZ, Li JJ, Chen HW. Kinesin family deregulation coordinated by bromodomain protein ANCCA and histone methyltransferase MLL for breast cancer cell growth, survival, and tamoxifen resistance. Mol Cancer Res. 2014 Apr;12(4):539-49. PMID:24391143 [[38]]


  • Chen P, Wang H, Duan Z, Zou JX, Chen H, He W, Wang J. Estrogen-related receptor alpha confers methotrexate resistance via attenuation of reactive oxygen species production and P53 mediated apoptosis in osteosarcoma cells. Biomed Res Int. 2014;2014:616025. PMID: 24967384 [[39]]


  • Hung CL, Wang LY, Yu YL, Chen HW, Srivastava S, Petrovics G, Kung HJ. A long noncoding RNA connects c-Myc to tumor metabolism. Proc Natl Acad Sci USA. 2014 Dec 30;111(52):18697-702. PMID: 25512540 [[40]]


  • Wang Y, Stokes A, Duan Z, Hui J, Xu Y, Chen Y, Chen HW, Lam K, Zhou CJ. LDL Receptor-Related Protein 6 Modulates Ret Proto-Oncogene Signaling in Renal Development and Cystic Dysplasia. J Am Soc Nephrol. 2015 Jun 5. [Epub ahead of print] PMID: 26047795 [[41]]


  • Krakstad C, Tangen IL, Hoivik EA, Halle MK, Berg A, Werner HM, Ræder MB, Kusonmano K, Zou JX, Øyan AM, Stefansson I, Trovik J, Kalland KH, Chen HW, Salvesen HB. ATAD2 overexpression links to enrichment of B-MYB-translational signatures and development of aggressive endometrial carcinoma. Oncotarget. 2015 Sep 29;6(29):28440-52. PMID: 26308378 [[42]]



  • Huang X, Zhang S, Qi H, Wang Z, Chen HW, Shao J, Shen J. JMJD5 interacts with p53 and negatively regulates p53 function in control of cell cycle and proliferation. BBA - Molecular Cell Research. 2015 Oct;1853:2286-95 PMID:26025680 [[43]]


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