User:Han Min Woo

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smsb.lab

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SMSB Lab at Korea Institute of Science and Technology, Seoul, Korea (KIST) is a multi-disciplinary laboratory to develop efficient microorganisms to produce valuable chemicals such as biofuels, biomaterials, and biochemicals etc from renewable resources i.e. biomasses. Our lab is running for the number one lab of the Bio-Refinery as new-paradigm of the chemical industry towards sustainable green growth.

Contact Info

  • Dr. Han Min Woo

Korea Institute of Science and Technology (KIST) Clean Energy Research Center

Hwarangno 14-gil 5, Seongbuk-gu Seoul, South Korea 136-791

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I work for Systems metabolic engineering and Synthetic Biology ([smsb.lab][2]).

Education

  • 2010, PhD, Heinrich-Heine Universität Düsseldorf/Forschungszentrum Jülich, Germany
  • 2006, MS, KAIST, Daejeon, Rep. of Korea
  • 2004, BS, Korea University, Seoul, Rep. of Korea

Professionals

11.2011 – Present: Senior Research Scientist, Clean Energy Research Center, Korea Institute of Science and Technology (KIST), Seoul, South Korea

11.2010 – 10.2011: Biologist Postdoctoral Fellow, Lawrence Berkeley National Laboratory, Physical Biosciences Division, Berkeley, CA, USA Metabolic engineering group, Fuels synthesis Division, Joint BioEnergy Institute, Emeryville, CA, USA 94608 (Prof. Jay Keasling)

06.2010 – 08.2010: Postdoctoral researcher, Research Center Jülich (Forschungszentrum Jülich), Institute of Biotechnology 1 (Prof. Michael Bott), Jülich, Germany

06.2007 – 06.2010: Research Associate, Research Center Jülich (Forschungszentrum Jülich), Institute of Biotechnology 1 (Prof. Michael Bott), Jülich, Germany

07.2006 – 05.2007: Research Associate, Division of Life Science, Korea Institute of Science and Technology (KIST), Seoul, South Korea

02.2004 – 02.2006: Research Associate, MBEL (Prof. Sang Yup Lee), Dep. of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), South Korea

Research interests

1. Metabolically engineered E. coli and C. glutamicum for advanced biofuels and biochemicals - Isoprenoid-based biofuels (Terpenes): Advanced bio-disel and aviation fuel (the next generation biofuels) - Production of biochemicals replacing petroleum-based chemicals.

2. Genetic tool development for metabolic engineering using synthetic biology - Systematic gene cloning using BglBrick and Golden Gate method - Systematic gene deletion and integration methods - Transcriptional and translational controls using RNAs - Genetic re-wiring of control units and biosensors

3. Systems biology with omics technologies - Genomics - Next generation genome sequencing technology - Transcriptomics - DNA microarray and Next generation seq. technology - Proteomics - MS-based targeted proteomics - Metabolomics - MS-based Metabolite profiling, targeted metablites

4. in silico flux balance analysis - Genome-scale metabolic flux balance analysis - Prediction of metabolic behaviors for metabolic engineering and synthetic biology

5. Regulations of cellular metabolisms and physiologies of E. coli and C. glutamicum - Characterization of two-component regulatory systems - in vitro or in situ validation of cellular regulations

5. de Novo pathways to microbe -Biochemical productions from carbon dioxide using engineered E. coli and C. glutamicum


[Keywords] Microbial metabolomics,, Metabolic Profiling, Bio-Refinery Computational & Quantitative Biology, Systems Biology, Integrated Biology, Microbiology, Metabolic engineering, Secondary metabolite production, Drug Development, Diagnostics, Toxicology, Synthetic Biology, Bio-fuel

Publications

[9] Woo, H.M. et al., The ArcAB-mediated amorphadiene production from E. coli, (2011) in preparation.

[8] Woo, H.M. et al., Gene titration of the mevalonate-based isoprenoid pathway in E. coli for the amorphadiene production, (2011) in preparation.

[7] Woo, H.M., Wessel, M., and Bott, M “SenX3-RegX3 (CgtS4-CgtR4), an essential two-component regulatory system of C. glutamicum involved in the phosphate starvation response, (2011). To be submitted to J Bacteriol.

[6] Woo, H.M., Noack, S., Seibold, G., Willbold, S., Eikmanns, B., and Bott, M. “Link between glycogen pathway and phosphate starvation response of Corynebacterium glutamicum, revealed by metabolomics, (2010).Appl. Environ. Microbiol. 76(20):6910-6919.

[5] Choi, H.S., Lee, S.Y., Kim, T.Y., and Woo, H.M. “in silico identification of gene amplification targets for improving lycopene production”, (2010) Appl. Environ. Microbiol. 76: 3097-3105.

[4] Woo, H.M., Kim, K.M., Choi, M.H., Jung, B.H., Lee, J., Kong, G., Nam, S.J., Kim, S., Bai, S.W. and Chung, B.C. “Mass spectrometry based metabolomic approaches in urinary biomarker study of women’s cancers”, (2009) Clinica Chimica Acta 400: 63-69.

[3] *Lee, S.H., *Woo, H.M., Jung, B.H., Lee, J., Kwon, O.S., Pyo, H.S., Choi, M.H. and Chung, B.C. “A Metabolomic approach to evaluate the toxicological effects of nonylphenol with rat urine”, (2007) Anal. Chem. 79:6102-6110. *Equally contributed

[2] Kim, J.S., Yun, H., Kim, H.U., Choi, H.S., Kim, T.Y., Woo, H.M., and Lee, S.Y. “Resources for systems biology research", (2006) J. Microbiol. Biotechnol.16:832-848.

[1] Lee, S.Y., Woo, H.M., Lee, D.-Y, Choi, H.S, Kim, T.Y. and Yoon H. “Systems-Level Analysis of Genome-Scale Microbial Metabolisms under the Integrated Software Environment”, (2005) Biotechnol. Bioproc. Eng. 10:425-431.


Patent: [1] Lee, S.Y., Woo, H.M., Choi, H.S., “Method for Improving a Useful Biomaterial Producing Organisms Using Flux Scanning Based on Enforced Objective Flux,” Korean Patent: appl. 10-2005-0086119 (9.15.2005) and PCT/KR2005/003074, Publication Nr.: WO/2007/032568 (2007.03.22)

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