User:Guobing Chen

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简介

Guobing Chen (an artistic interpretation)

本课题组主要从事T细胞研究，包括抗原特异性T细胞TCR组库和T细胞免疫记忆的研究！

联系方式：

• 陈国兵 博士
• 广州医科大学基础学院基础医学研究中心副教授，PI，硕士生导师
• 广东省广州市东风西路195号广州医科大学16号楼2楼
• Email: mailto:guobing.chen@gmail.com

Education

• 2007-2011, PhD, John Curtin School of Medical Research, Australia National University
• 2001-2004, 免疫学硕士, 东南大学
• 1997-2000, 临床医学, 安徽医科大学

研究方向

1. 研究方向一：抗原特异性TCR组库的鉴定、功能检测和应用
2. 研究方向二：免疫记忆的形成机制

Publications

1. Chen G, Yang X, Ko A, Sun X, Gao M, Zhang Y, Shi A, Mariuzza RA, and Weng NP. Sequence and Structural Analyses Reveal Distinct and Highly Diverse Human CD8(+) TCR Repertoires to Immunodominant Viral Antigens. Cell Rep. 2017 Apr 18;19(3):569-583. DOI:10.1016/j.celrep.2017.03.072 |
2. Li HM, Hiroi T, Zhang Y, Shi A, Chen G, De S, Metter EJ, Wood WH 3rd, Sharov A, Milner JD, Becker KG, Zhan M, and Weng NP. TCRβ repertoire of CD4+ and CD8+ T cells is distinct in richness, distribution, and CDR3 amino acid composition. J Leukoc Biol. 2016 Mar;99(3):505-13. DOI:10.1189/jlb.6A0215-071RR |
3. Yang X, Gao M, Chen G, Pierce BG, Lu J, Weng NP, and Mariuzza RA. Structural Basis for Clonal Diversity of the Public T Cell Response to a Dominant Human Cytomegalovirus Epitope. J Biol Chem. 2015 Nov 27;290(48):29106-19. DOI:10.1074/jbc.M115.691311 |
4. Najarro K, Nguyen H, Chen G, Xu M, Alcorta S, Yao X, Zukley L, Metter EJ, Truong T, Lin Y, Li H, Oelke M, Xu X, Ling SM, Longo DL, Schneck J, Leng S, Ferrucci L, and Weng NP. Telomere Length as an Indicator of the Robustness of B- and T-Cell Response to Influenza in Older Adults. J Infect Dis. 2015 Oct 15;212(8):1261-9. DOI:10.1093/infdis/jiv202 |
5. Slota C, Shi A, Chen G, Bevans M, and Weng NP. Norepinephrine preferentially modulates memory CD8 T cell function inducing inflammatory cytokine production and reducing proliferation in response to activation. Brain Behav Immun. 2015 May;46:168-79. DOI:10.1016/j.bbi.2015.01.015 |
6. Chen G, Lustig A, and Weng NP. T cell aging: a review of the transcriptional changes determined from genome-wide analysis. Front Immunol. 2013;4:121. DOI:10.3389/fimmu.2013.00121 |
7. Chen G and Shannon M. Transcription factors and th17 cell development in experimental autoimmune encephalomyelitis. Crit Rev Immunol. 2013;33(2):165-82. DOI:10.1615/critrevimmunol.2013006959 |
8. Chen G and Weng NP. Analyzing the phenotypic and functional complexity of lymphocytes using CyTOF (cytometry by time-of-flight). Cell Mol Immunol. 2012 Jul;9(4):322-3. DOI:10.1038/cmi.2012.16 |
9. Li Y, Chen G, Ma L, Ohms SJ, Sun C, Shannon MF, and Fan JY. Plasticity of DNA methylation in mouse T cell activation and differentiation. BMC Mol Biol. 2012 May 29;13:16. DOI:10.1186/1471-2199-13-16 |
10. Chen G, Hardy K, Pagler E, Ma L, Lee S, Gerondakis S, Daley S, and Shannon MF. The NF-κB transcription factor c-Rel is required for Th17 effector cell development in experimental autoimmune encephalomyelitis. J Immunol. 2011 Nov 1;187(9):4483-91. DOI:10.4049/jimmunol.1101757 |
11. Chen G, Hardy K, Bunting K, Daley S, Ma L, and Shannon MF. Regulation of the IL-21 gene by the NF-κB transcription factor c-Rel. J Immunol. 2010 Aug 15;185(4):2350-9. DOI:10.4049/jimmunol.1000317 |
12. Dou J, Hong X, Zhao F, Wang J, Chen J, and Chen G. Investigation of GM-CSF immune accessory effects in tumor-bearing mice by direct gene immunization. Immunol Invest. 2006;35(2):227-37. DOI:10.1080/08820130600634550 |
13. Tang W, Chen G, Gu Q, Pan J, and Wu W. Expression, purification and identification of recombinant mouse interleukin 21 protein in E. coli. Cell Mol Immunol. 2006 Aug;3(4):311-5.
14. Dou J, Chen JS, Wang J, Chen GB, Zhao FS, Tang Q, Fang XS, Chu LL, and Pan M. Novel constructs of tuberculosis gene vaccine and its immune effect on mice. Cell Mol Immunol. 2005 Feb;2(1):57-62.
15. Chen GB and Meng JH. Identification of 5' capped structure and 3' terminal sequence of hepatitis E virus isolated from Morocco. World J Gastroenterol. 2004 Jul 15;10(14):2045-9. DOI:10.3748/wjg.v10.i14.2045 |
16. Dou J, Chen G, Wang J, Zhao F, Chen J, Fang X, Tang Q, and Chu L. Preliminary study on mouse interleukin-21 application in tumor gene therapy. Cell Mol Immunol. 2004 Dec;1(6):461-6.
17. Chen GB, Dou J, Chen JS, and Hong XW. [Cloning and eukaryotic expression of mouse interleukin 21]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2004 Jan;20(1):49-52.

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18. ISBN:7810893319
19. ISBN:9787564109691

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