- Eyad Lababidi
- University of Virginia
- 116B Carrollton Terrace
Charlottesville, VA, USA
3rd Year, BS, Institute
Genetic Parts This article really opened up my eyes to the possibilities of parts that could be used in cells. I never realized the capabilities were already so broad, but what i do not understand is if certain chemicals are the inputs and outputs for each part that is acting as an actuator or a circuit or an input device then isnt there a limit on the number of different chemicals you can modify and have to carefully pay attention to the effects of the changing environment on capability of the parts, which explains why characterization is so important but to characterize the parts in endless amounts of different situations due to different chemical levels seems quite impossible. This also explains why the article explains that simple biosynthesized cells have been realized while complex cells will have a much harder time to be completed successfulle.
Idempotent Vector Design I definitely agree that the standardization of biosynth will create the next industrial revolution because it will open up doors of understanding in a field that has had a lot of smoke and mirrors for the inner workings of cells. With standardization of not only cut sites but also process it makes the products interchangeable with other users and cheap to produce. Having the process standardized also makes it easier for new users to know what not to do in cases liek repeating code patterns that should not be repeat in order to complete the biosynthetic process. I did not understand the explanation on how the cuts actually happen and where the new genes are inserted and i hope that we can go over that during discussion.
Eyad Lababidi 16:29, 27 January 2008 (CST)
- Goldbeter A and Koshland DE Jr. An amplified sensitivity arising from covalent modification in biological systems. Proc Natl Acad Sci U S A. 1981 Nov;78(11):6840-4. DOI:10.1073/pnas.78.11.6840 |
- JACOB F and MONOD J. Genetic regulatory mechanisms in the synthesis of proteins. J Mol Biol. 1961 Jun;3:318-56. DOI:10.1016/s0022-2836(61)80072-7 |
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