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- 1 Synopsis
- 2 Antidepressant properties of THC
- 3 Neuroprotective properties of THC
- 4 Effects of THC on neurogenesis, synaptogenesis and BDNF signaling
- 5 Neuropsychology of THC tolerance
- 6 Notes
- 7 Experimental
- 8 References
- 9 See also
- Delta9-tetrahydrocannabinol (THC) is the main psychoactive constituent of the Cannabis sativa L (Marijuana) plant.
- Others marijuana-derived cannabinoids includes Cannabichromene (CBC), Cannabidiol (CBD), Cannabinol (CBN), Cannabigerol (CBG), and Tetrahydrocannabivarin (THCV).
- Marijuana-derived cannabinoids are known as phytocannabinoids.
- THCA is the biosynthetic precursor of THC.
Antidepressant properties of THC
- THC stimulate anandamide biosynthesis by binding to the CB1 receptor, thus producing a antidepressant and neuroprotective effect. 
Neuroprotective properties of THC
- THC may inhibit acetylcholinesterase-induced intraneuronal amyloid beta aggregation in Alzheimer's disease. 
- THC may prevent intracellular amyloid beta proteotoxicity and inflammatory response. 
Antipsychotic-induced dopamine supersensitivity
- THC is effective glutamatergic agent for reversing drug-induced neuronal excitotoxicity. 
- THC may reverse the cognitive aging process in the brain. (Reference needed)
- THC may reduce intraocular pressure (IOP) in retinal ganglion cells (RGCs) through intracellular CB1 receptor activation.
- A potential treatment for glaucoma to prevent optic nerve damage.
Traumatic brain injury
- Do THC exert a neuroprotective effect on TBI?
Posttraumatic stress disorder
- THC may reduce chronic nightmares frequency and alter dreaming activity?
- THC may affect REM-sleep rebound. 
- THC may reduce REM-sleep and increase slow wave sleep (SWS).
Effects of THC on neurogenesis, synaptogenesis and BDNF signaling
- Hippocampal CB1 receptors regulate stress-induced neuroinflammation in the hippocampus. 
- THC enhance adult hippocampal neurogenesis and BDNF signaling through intracellular CB1 receptor activation. 
- Intracellular CB1 activation promote neuronal cell proliferation, differentiation, maturation, and neurite growth. 
Neuropsychology of THC tolerance
- CB1 receptor sensitization can be restored by taking breaks of oral THC administration. (Reference needed)
- Alcohol increase THC levels in blood. (Reference needed)
- THC tolerance is genetic and regulated by the AKT1 gene.
- THC may increase serotonergic tone. 
- Possible cross-talk between dopaminergic vitamin D, delta9-THC, and endogenous cannabinoids (anandamide) ?
- Endogenous retrograde trafficking may promote hippocampal development (neurogenesis) and synaptogenesis.
- Arachidonic acid/DHA levels affect neural stem/progenitor cells (NSPCs) proliferation in the hippocampus. (Reference needed)
- THC may enhance corticostriatal functional connectivity though increased c-Fos expression. 
- Long-term THC administration may depletes melatonin synthesis.
Antidepressant-like effect of Δ9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L.
A molecular link between the active component of marijuana and Alzheimer's disease pathology.
Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids.
Endocannabinoid signaling in neurotoxicity and neuroprotection.
Potential role of the cannabinoid receptor CB1 in rapid eye movement sleep rebound.
Regulatory role of cannabinoid receptor 1 in stress-induced excitotoxicity and neuroinflammation.
Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects.
Alzheimer's disease; taking the edge off with cannabinoids?
Activation of type 1 cannabinoid receptor (CB1R) promotes neurogenesis in murine subventricular zone cell cultures.
Low serotonergic tone and elevated risk for substance misuse.
Neural correlates of interactions between cannabidiol and Δ(9) -tetrahydrocannabinol in mice: implications for medical cannabis.
Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia.
A chronic low dose of Δ9-tetrahydrocannabinol (THC) restores cognitive function in old mice.
Effect of marijuana use on outcomes in traumatic brain injury.