User:Etienne Robillard/Notebook/Brainstorming

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Microglial activation in the PFC

  • Activation of the microglia by aluminium oxide disrupt the cytokine/neurotrophin balance.
  • Possible role of microglia-derived BDNF signaling on intracellular Ca2+ elevation? [1]

Nanotoxicity of fine particulate matter (PM2.5)

  • Fly-ash particulate matter includes:
    • aluminium oxide
    • silicon dioxide
    • titanium dioxide
    • barium oxide
    • iron oxide
    • cadmium
    • arsenic
    • dimethyl sulfate and monomethyl sulfate[2]
  • Exposure to coal fly ash is nanotoxic and may cause neuroinflammation via oxidative stress production. [3]
  • Coal fly ash is a source of particulate matter.
  • Fine particulate matter (PM2.5) exposure may induce chronic COPD pathogenesis.[4]

Neurodiversity

Neuropolitics

Phenomenology of consciousness

The brain is not the source of consciousness:

Intrinsic awareness (IA):

Ubiquity of consciousness:

Political manipulations of psychiatry

Sluggish schizophrenia

Retrograde signaling

Glycinergic neurotransmission trafficking

Allosteric modulation of glycine receptors by endocannabinoids

  • THC and anandamide may modulates synaptogenesis in the retina and brain through glycinergic transmission [5]
  • Intracellular DHA delivery facilitate glutamatergic NMDA receptor function in the presence of glycine [6]
  • THC and anandamide enhance NMDA-dependent LTP through glycine receptor activation

CB1-induced cholinergic neurotransmission

  • Hypothalamic POMC neurons promote CB1-induced feeding [7]
  • Adenosine antagonist (caffeine) potentiate corticostriatal neurotransmission (connectivity) through presynaptic CB1 receptor activation. [8]
  • Monoamine oxidase inhibition affects cannabinoid-induced synaptogenesis. [9]

Intracellular CB1/BDNF signaling

  • CB1 receptor activation may induce corticostriatal neuroprotection through a PI3K/Akt/mTORC1/BDNF pathway. [10]

Pineal gland

  • Dopamine receptors in the pineal gland may control melatonin production via anandamide trafficking? [11][12]

Social neuroscience of cannabis smoking

Synaptic hypercomputation

Biological utilization of quantum non-locality in microtubules:

Biophotonic non-locality of tubulin heterodimer:

  • The non-local (quantum) nature of biophotonic energy may require ultra-fast optical communication channels in MTs to potentiate a presynaptic action potential into a visible waveform! (Reference needed)
  • Is the tubulin dipole moment phase-dependent? (Reference needed)


Phase coherence of synaptic hypercomputation

Retrograde signaling and synaptogenesis:

References

  1. https://www.ncbi.nlm.nih.gov/pubmed/25171395 [Paper11]
    Positive feedback loop of autocrine BDNF from microglia causes prolonged microglia activation.
  2. https://www.ncbi.nlm.nih.gov/pubmed/7350652 [Paper8]
    Dimethyl and monomethyl sulfate: presence in coal fly ash and airborne particulate matter.
  3. http://particleandfibretoxicology.biomedcentral.com/articles/10.1186/1743-8977-2-10 [Paper9]
    Combustion-derived nanoparticles: A review of their toxicology following inhalation exposure.
  4. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617054/ [Paper10]
    Fine particulate matter in acute exacerbation of COPD.
  5. https://www.ncbi.nlm.nih.gov/pubmed/16332990 [Paper2]
    Delta9-tetrahydrocannabinol and endogenous cannabinoid anandamide directly potentiate the function of glycine receptors.
  6. https://www.ncbi.nlm.nih.gov/pubmed/7514666 [Paper3]
    Facilitatory effect of docosahexaenoic acid on N-methyl-D-aspartate response in pyramidal neurones of rat cerebral cortex.
  7. https://www.ncbi.nlm.nih.gov/pubmed/25707796 [Paper4]
    Hypothalamic POMC neurons promote cannabinoid-induced feeding.
  8. https://www.ncbi.nlm.nih.gov/pubmed/19027757 [Paper5]
    Caffeine drinking potentiates cannabinoid transmission in the striatum: interaction with stress effects.
  9. https://www.ncbi.nlm.nih.gov/pubmed/23858446 [Paper6]
    Cognitive abnormalities and hippocampal alterations in monoamine oxidase A and B knockout mice.
  10. https://www.ncbi.nlm.nih.gov/pubmed/25698444 [Paper7]
    The CB₁ cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway.
  11. https://www.ncbi.nlm.nih.gov/pubmed/18554250 [Paper25]
    The rat pineal gland comprises an endocannabinoid system.
  12. https://www.ncbi.nlm.nih.gov/pubmed/26061461 [Paper26]
    Rhythmic control of endocannabinoids in the rat pineal gland.
  13. https://www.jstage.jst.go.jp/article/jts/36/3/36_3_267/_article [Paper1]
    Nasal instillation of nanoparticle-rich diesel exhaust particles slightly affects emotional behavior and learning capability in rats
  14. http://pubs.rsc.org/en/content/articlelanding/2017/tx/c6tx00314a [Paper12]
    Synergistic effects of particulate matter (PM2.5) and sulfur dioxide (SO2) on neurodegeneration via the microRNA-mediated regulation of tau phosphorylation.
  15. http://jaapl.org/content/35/4/469 [Paper13]
    Amnesia and Crime.
  16. http://journal.frontiersin.org/article/10.3389/fphar.2016.00355/full [Paper14]
    Splendor in the Grass? A Pilot Study Assessing the Impact of Medical Marijuana on Executive Function
  17. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098150/ [Paper15]
    Possible existence of optical communication channels in the brain
  18. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653148/ [Paper16]
    Endocannabinoid signaling mediates oxytocin-driven social reward
  19. https://www.ncbi.nlm.nih.gov/pubmed/11826965 [Paper17]
    Antihypertensive effects of acetic acid and vinegar on spontaneously hypertensive rats.
  20. https://www.ncbi.nlm.nih.gov/pubmed/27264948 [Paper18]
    Antipsychotic Induced Dopamine Supersensitivity Psychosis: A Comprehensive Review.
  21. https://www.ncbi.nlm.nih.gov/pubmed/26419755 [Paper19]
    Vitamin D deficiency and essential hypertension.
  22. http://www.sciencedirect.com/science/article/pii/S2251729413000050 [Paper20]
    Vitamin D as an effective treatment approach for drug abuse and addiction.
  23. https://www.ncbi.nlm.nih.gov/pubmed/24739187 [Paper21]
    The in vitro GcMAF effects on endocannabinoid system transcriptionomics, receptor formation, and cell activity of autism-derived macrophages.
  24. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266250/ [Paper22]
    Potential of garlic (Allium sativum) in lowering high blood pressure: mechanisms of action and clinical relevance.
  25. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783408/ [Paper23]
    Psychosis and the Control of Lucid Dreaming.
  26. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604174/ [Paper24]
    Cannabis in the Treatment of Dystonia, Dyskinesias, and Tics.
  27. https://www.ncbi.nlm.nih.gov/pubmed/17439547 [Paper27]
    Melatonin as a potential antihypertensive treatment.
  28. https://www.ncbi.nlm.nih.gov/pubmed/22527998 [Paper28]
    Melatonin: an overlooked factor in schizophrenia and in the inhibition of anti-psychotic side effects.
  29. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955008/ [Paper29]
    Multiple Mechanistically Distinct Modes of Endocannabinoid Mobilization at Central Amygdala Glutamatergic Synapses.
  30. https://www.ncbi.nlm.nih.gov/pubmed/28240187 [Paper30]
    The endocannabinoid system modulating levels of consciousness, emotions and likely dream contents.
  31. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489624/ [Paper31]
    Insights into plant consciousness from neuroscience, physics and mathematics: A role for quasicrystals?
  32. https://www.researchgate.net/publication/285705600_Dreams_and_neuroholography_An_interdisciplinary_Interpretation_of_development_of_homeotherm_state_in_evolution [Paper31]
    Dreams and neuroholography: An interdisciplinary. Interpretation of development of homeotherm state in evolution

See also