User:Deng-Ke Niu

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Contact Info

Deng-Ke Niu (an artistic interpretation)


  • 1999, PhD, Wuhan University
  • 1996, MS, Lanzhou University
  • 1993, BS, Hebei University
  • 2001-2003, Postdoc, Beijing Normal University
  • 2000-2001, CNRS-University Paul Sabatier, Toulouse III
  • 1999-2001, Institute of Hydrobiology, The Chinese Academy of Sciences, Wuhan

Research interests

  1. The origin and evolution of introns, including the possible costs and benefits of introns, the mechanisms of intron gain and intron loss
  1. Theoretical consideration on various problems. Propose hypotheses to remind other researchers the unnoticed possibilities.


  • Niu D-K, Cao J-L (2010) Nucleosome deposition and DNA methylation may participate in the recognition of premature termination codon in nonsense-mediated mRNA decay. FEBS Lett. 584:3509-3512
  • Li N, Lv J, Niu D-K (2009) Low contents of carbon and nitrogen in highly abundant proteins: Evidence of selection for the economy of atomic composition. J. Mol. Evol. 68:248-255
  • Huang Y-F, Niu D-K (2008) Evidence against the energetic cost hypothesis for the short introns in highly expressed genes. BMC Evol. Biol. 8:154
  • Niu DK (2008) Exon definition as a potential negative force against intron losses in evolution. Biol. Direct 3:46
  • Lv J, Li N, Niu D-K (2008) Association between the availability of environmental resources and the atomic composition of organismal proteomes: Evidence from Prochlorococcus strains living at different depths. Biochem. Biophys. Res. Commun. 375:241-246
  • Wang HF, Hou WR, Niu DK (2008) Strand compositional asymmetries in vertebrate large genes. Mol. Biol. Rep. 35:163-169
  • Niu D-K (2007) Protecting exons from deleterious R-loops: a potential advantage of having introns. Biol. Direct 2:11
  • Li S-W, Feng L, Niu D-K (2007) Selection for the miniaturization of highly expressed genes. Biochem. Biophys. Res. Commun. 360:586-592
  • Wang H-F, Feng L, Niu D-K (2007) Relationship between mRNA stability and intron presence. Biochem. Biophys. Res. Commun. 354:203-208
  • Feng L, Niu D-K (2007) Relationship between mRNA stability and length: An old question with a new twist. Biochem. Genet. 45:131-137
  • Hou W-R, Wang H-F, Niu D-K (2006) Replication-associated strand asymmetries in vertebrate genomes and implications for replicon size, DNA replication origin, and termination. Biochem. Biophys. Res. Commun. 344:1258-1262
  • Niu D-K (2005) Low-level illegitimate transcription of genes may be to silence the genes. Biochem. Biophys. Res. Commun. 337:413-414
  • Niu D-K, Hou W-R, Li S-W (2005) mRNA-mediated intron losses: evidence from extraordinarily large exons. Mol. Biol. Evol. 22:1475-1481
  • Niu DK, Lin K, Zhang D-Y (2003) Strand compositional asymmetries of nuclear DNA in eukaryotes. J. Mol. Evol. 57:325-334
  • Niu DK, Chen JK, Liu YD (2001) Margulis' theory on division of labour in cells revisited. Acta Biotheor. 49:23-28
  • Niu DK, Chen JK (1998) Origin of cancerous cells from tumours. Acta Biotheor. 46:379-381
  • Niu DK, Chen JK (1997) Evolutionary advantages of cell specialization: Save and protect DNA. J. Theor. Biol. 187:39-43
  • Niu DK, Wang MG, Wang YF (1997) Plant cellular osmotica. Acta Biotheor. 45:161-169
  • Niu DK, Wang YF (1995) Why animals have tumors. Acta Biotheor. 43:279-280
  • And several papers in Chinese with English abstracts.
  • for abstracts and links to fulltexts, please search Pubmed[1]

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