User:David Simar

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Contact Info

David Simar (an artistic interpretation)
  • David Simar
  • University of New South Wales
  • Inflammation and Infection Research Centre
  • School of Medical Sciences
  • Sydney, NSW, Australia
  • Email me through OpenWetWare


  • 2004, PhD, University of Montpellier, France
  • 2000, MRes, University of Montpellier, France
  • 1998, BSc, University of Montpellier, France

Research interests

  1. Metabolism
  2. Immunology
  3. Skeletal Muscle

[I am a CI of the Inflammation and Infection Research Centre at the University of New South Wales, where I lead the Metabolic Disorders Research Group]


  1. Leucine improves glucose and lipid status in offspring from obese dams, dependent on diet type, but not caloric intake.

    Chen H, Simar D, Morris MJ. J Neuroendocrinol. 2012 2012 Oct;24(10):1356-64. PMID: 22612562

  2. Heat shock proteins induction reduces stress kinases activation, potentially improving insulin signalling in monocytes from obese subjects.

    Simar D, Jacques A, Caillaud C. Cell Stress Chaperones. 2012 Sep;17(5):615-21. PMID: 22457223

  3. Effect of an 8-weeks aerobic training program in elderly on oxidative stress and HSP72 expression in leukocytes during antioxidant supplementation. Simar D, Malatesta D, Mas E, Delage M, Caillaud C. J Nutr Health Aging. 2012 Feb;16(2):155-61. PMID: 22323351 [Paper18]
  4. Basal plasma leptin levels in healthy elderly males are related to physical fitness without impact on bone metabolism. Maïmoun L, Simar D, Caillaud C, Coste O, Puech AM, Jaussent A, Mariano-Goulart D, Sultan C. J Sports Med Phys Fitness. 2011 Mar;51(1):160-8. PMID: 21297576 [Paper17]
  5. Interaction between maternal obesity and post-natal over-nutrition on skeletal muscle metabolism. Simar D, Chen H, Lambert K, Mercier J, Morris MJ. Nutr Metab Cardiovasc Dis. 2012 Mar;22(3):269-76. Epub 2011 Jan 3. PMID: 21208789 [Paper16]
  6. Effect of an overground walking training on gait performance in healthy 65- to 80-year-olds. Malatesta D, Simar D, Saad HB, Préfaut C, Caillaud C. Exp Gerontol. 2010 Jun;45(6):427-34. Epub 2010 Mar 18. PMID: 20303403 [Paper15]
  7. Hypothalamic neuroendocrine circuitry is programmed by maternal obesity: interaction with postnatal nutritional environment. Chen H, Simar D, Morris MJ. PLoS One. 2009 Jul 16;4(7):e6259. PMID: 19606226 [Paper14]
  8. Glucose Tranporter-4 expression in monocytes: a systematic review. Mavros Y, Simar D, Singh MA. Diabetes Res Clin Pract. 2009 May;84(2):123-31. Epub 2009 Mar 14. Review. PMID: 19286271 [Paper13]
  9. Adaptations to exercise training within skeletal muscle in adults with type 2 diabetes or impaired glucose tolerance: a systematic review. Wang Y, Simar D, Fiatarone Singh MA. Diabetes Metab Res Rev. 2009 Jan;25(1):13-40. Review. PMID: 19143033 [Paper12]
  10. Response of calciotropic hormones and bone turnover to brisk walking according to age and fitness level. Maïmoun L, Simar D, Caillaud C, Coste O, Barbotte E, Peruchon E, Rossi M, Mariano-Goulart D. J Sci Med Sport. 2009 Jul;12(4):463-7. Epub 2008 Sep 2. PMID: 18768364 [Paper11]
  11. Maternal and postnatal overnutrition differentially impact appetite regulators and fuel metabolism. Chen H, Simar D, Lambert K, Mercier J, Morris MJ. Endocrinology. 2008 Nov;149(11):5348-56. Epub 2008 Jul 17. PMID: 18635655 [Paper10]
  12. Physical activity modulates heat shock protein-72 expression and limits oxidative damage accumulation in a healthy elderly population aged 60 90 years. Simar D, Malatesta D, Badiou S, Dupuy AM, Caillaud C. J Gerontol A Biol Sci Med Sci. 2007 Dec;62(12):1413-9. PMID: 18166694 [Paper9]
  13. Effect of antioxidants and exercise on bone metabolism. Maïmoun L, Simar D, Caillaud C, Peruchon E, Sultan C, Rossi M, Mariano-Goulart D. J Sports Sci. 2008 Feb 1;26(3):251-8. PMID: 18074298 [Paper8]
  14. Response of bone metabolism related hormones to a single session of strenuous exercise in active elderly subjects. Maïmoun L, Simar D, Malatesta D, Caillaud C, Peruchon E, Couret I, Rossi M, Mariano-Goulart D. Br J Sports Med. 2005 Aug;39(8):497-502. PMID: 16046330 [Paper7]
  15. Aerobic and functional capacities in a selected active population of European octogenarians. Simar D, Malatesta D, Dauvilliers Y, Préfaut C, Varray A, Caillaud C. Int J Sports Med. 2005 Mar;26(2):128-33. PMID: 15726488 [Paper6]
  16. Effect of age on Hsp72 expression in leukocytes of healthy active people. Simar D, Malatesta D, Koechlin C, Cristol JP, Vendrell JP, Caillaud C. Exp Gerontol. 2004 Oct;39(10):1467-74. PMID: 15501016 [Paper5]
  17. Strengths and weaknesses of established indirect models to detect recombinant human erythropoietin abuse on blood samples collected 48-hr post administration. Connes P, Caillaud C, Simar D, Villard S, Sicart MT, Audran M. Haematologica. 2004 Jul;89(7):891-2. PMID: 15257956 [Paper4]
  18. Does oxidative stress alter quadriceps endurance in chronic obstructive pulmonary disease? Koechlin C, Couillard A, Simar D, Cristol JP, Bellet H, Hayot M, Prefaut C. Am J Respir Crit Care Med. 2004 May 1;169(9):1022-7. Epub 2004 Mar 4. PMID: 15001462 [Paper3]
  19. Aerobic determinants of the decline in preferred walking speed in healthy, active 65- and 80-year-olds. Malatesta D, Simar D, Dauvilliers Y, Candau R, Ben Saad H, Préfaut C, Caillaud C. Pflugers Arch. 2004 Mar;447(6):915-21. Epub 2003 Dec 10. PMID: 14666424 [Paper2]
  20. Energy cost of walking and gait instability in healthy 65- and 80-yr-olds. Malatesta D, Simar D, Dauvilliers Y, Candau R, Borrani F, Prefaut C, Caillaud C. J Appl Physiol. 2003 Dec;95(6):2248-56. Epub 2003 Jul 25. PMID: 12882986 [Paper1]
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