User:Daphne Georlette

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  • University of Liege (Belgium), Ph.D. (summa cum laude), 2003, Biochemistry
  • University of Liege (Belgium), B.Sc. (summa cum laude), 1996, Biochemistry

Professional Experience

Honors and Awards

  • 2003-2004: B.A.E.F. Postdoctoral Fellowship

Selected Publications see complete list in pubmed

  • Georlette D, Ahn S, MacAlpine DM, Cheung E, Lewis PW, Beall EL, Bell SP, Speed T, Manak JR, Botchan MR. (2007). Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cells. Genes & Development 21(22):2880-96.
  • Lewis PW, Beall EL, Fleischer TC, Georlette D, Link AJ, Botchan MR. (2004). Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex. Genes & Development 18(23):2929-40.
  • Beall EL, Bell M, Georlette D, Botchan MR. (2004). Dm-myb mutant lethality in Drosophila is dependent upon mip130: positive and negative regulation of DNA replication. Genes & Development 18(14):1667-80.
  • Georlette D, Blaise V, Collins T, D'Amico S, Gratia E, Hoyoux A, Marx JC, Sonan G, Feller G, Gerday C. (2004). Some like it cold: biocatalysis at low temperatures. FEMS Microbiology Reviews 28(1):25-42. Review.
  • Georlette D, Blaise V, Bouillenne F, Damien B, Thorbjarnardottir SH, Depiereux E, Gerday C, Uversky VN, Feller G. (2004). Adenylation-dependent conformation and unfolding pathways of the NAD+-dependent DNA ligase from the thermophile Thermus scotoductus. Biophysical Journal 86(2):1089-104.
  • Georlette D, Blaise V, Dohmen C, Bouillenne F, Damien B, Depiereux E, Gerday C, Uversky VN, Feller G. (2003). Cofactor binding modulates the conformational stabilities and unfolding patterns of NAD(+)-dependent DNA ligases from Escherichia coli and Thermus scotoductus. Journal of Biological Chemistry 278(50):49945-53.
  • Georlette D, Damien B, Blaise V, Depiereux E, Uversky VN, Gerday C, Feller G. (2003). Structural and functional adaptations to extreme temperatures in psychrophilic, mesophilic, and thermophilic DNA ligases. Journal of Biological Chemistry 278(39):37015-23.
  • Georlette D, Jonsson ZO, Van Petegem F, Chessa J, Van Beeumen J, Hubscher U, Gerday C. (2000). A DNA ligase from the psychrophile Pseudoalteromonas haloplanktis gives insights into the adaptation of proteins to low temperatures. European Journal of Biochemistry 267(12):3502-12.
  • Meyer G, Hanon E, Georlette D, Pastoret PP, Thiry E. (1998). Bovine herpesvirus type 1 glycoprotein H is essential for penetration and propagation in cell culture. J Gen Virol. 79(Pt8):1983-7.


Temple University,
College of Science and Technology,
Biology Department
1900 N. 12th Street, Biology Life Sciences Building room#436
Philadelphia, PA 19122
Phone: 215-204-0291 (office) / 215-204-1925 (lab)
Fax: 215-204-6646
Email: daph [at] temple [dot] edu