User:Christopher J. Marx

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Contact Info

Christopher J. Marx

• Christopher J. Marx
• Assistant Professor of Biology
• Department of Organismic and Evolutionary Biology
• Harvard University
• 3083 Biological Laboratories
• 16 Divinity Avenue
• Cambridge, MA 02138 USA
• cmarx (at) oeb (dot) harvard (dot) edu
• 617.496.8103

I'm an advisor for the Harvard 2008 iGEM team.

Education

• 2003, PhD, Microbiology, University of Washington
• 1997, SB, Biology, Massachusetts Institute of Technology
• 1997, SB, Civil and Environmental Engineering, Massachusetts Institute of Technology

Research interests

1. Experimental evolution of microbes to address broad evolutionary and ecological questions and explore the systems-level function and optimization of complex biological networks.

Publications

1. Chain PS, Denef VJ, Konstantinidis KT, Vergez LM, Agulló L, Reyes VL, Hauser L, Córdova M, Gómez L, González M, Land M, Lao V, Larimer F, LiPuma JJ, Mahenthiralingam E, Malfatti SA, Marx CJ, Parnell JJ, Ramette A, Richardson P, Seeger M, Smith D, Spilker T, Sul WJ, Tsoi TV, Ulrich LE, Zhulin IB, and Tiedje JM. Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome shaped for versatility. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15280-7. DOI:10.1073/pnas.0606924103 |
2. Kalyuzhnaya MG, Korotkova N, Crowther G, Marx CJ, Lidstrom ME, and Chistoserdova L. Analysis of gene islands involved in methanopterin-linked C1 transfer reactions reveals new functions and provides evolutionary insights. J Bacteriol. 2005 Jul;187(13):4607-14. DOI:10.1128/JB.187.13.4607-4614.2005 |
3. Marx CJ, Van Dien SJ, and Lidstrom ME. Flux analysis uncovers key role of functional redundancy in formaldehyde metabolism. PLoS Biol. 2005 Feb;3(2):e16. DOI:10.1371/journal.pbio.0030016 |

   Highlighted in Nature Reviews Microbiology 3:103

4. Marx CJ, Miller JA, Chistoserdova L, and Lidstrom ME. Multiple formaldehyde oxidation/detoxification pathways in Burkholderia fungorum LB400. J Bacteriol. 2004 Apr;186(7):2173-8. DOI:10.1128/JB.186.7.2173-2178.2004 |
5. Chistoserdova L, Jenkins C, Kalyuzhnaya MG, Marx CJ, Lapidus A, Vorholt JA, Staley JT, and Lidstrom ME. The enigmatic planctomycetes may hold a key to the origins of methanogenesis and methylotrophy. Mol Biol Evol. 2004 Jul;21(7):1234-41. DOI:10.1093/molbev/msh113 |
6. Marx CJ and Lidstrom ME. Development of an insertional expression vector system for Methylobacterium extorquens AM1 and generation of null mutants lacking mtdA and/or fch. Microbiology (Reading). 2004 Jan;150(Pt 1):9-19. DOI:10.1099/mic.0.26587-0 |
7. Van Dien SJ, Marx CJ, O'Brien BN, and Lidstrom ME. Genetic characterization of the carotenoid biosynthetic pathway in Methylobacterium extorquens AM1 and isolation of a colorless mutant. Appl Environ Microbiol. 2003 Dec;69(12):7563-6. DOI:10.1128/AEM.69.12.7563-7566.2003 |
8. Marx CJ, Chistoserdova L, and Lidstrom ME. Formaldehyde-detoxifying role of the tetrahydromethanopterin-linked pathway in Methylobacterium extorquens AM1. J Bacteriol. 2003 Dec;185(24):7160-8. DOI:10.1128/JB.185.23.7160-7168.2003 |
9. Marx CJ, Laukel M, Vorholt JA, and Lidstrom ME. Purification of the formate-tetrahydrofolate ligase from Methylobacterium extorquens AM1 and demonstration of its requirement for methylotrophic growth. J Bacteriol. 2003 Dec;185(24):7169-75. DOI:10.1128/JB.185.24.7169-7175.2003 |
10. Marx CJ, O'Brien BN, Breezee J, and Lidstrom ME. Novel methylotrophy genes of Methylobacterium extorquens AM1 identified by using transposon mutagenesis including a putative dihydromethanopterin reductase. J Bacteriol. 2003 Jan;185(2):669-73. DOI:10.1128/JB.185.2.669-673.2003 |
11. Marx CJ and Lidstrom ME. Broad-host-range cre-lox system for antibiotic marker recycling in gram-negative bacteria. Biotechniques. 2002 Nov;33(5):1062-7. DOI:10.2144/02335rr01 |
12. Marx CJ and Lidstrom ME. Development of improved versatile broad-host-range vectors for use in methylotrophs and other Gram-negative bacteria. Microbiology (Reading). 2001 Aug;147(Pt 8):2065-2075. DOI:10.1099/00221287-147-8-2065 |
13. Vorholt JA, Marx CJ, Lidstrom ME, and Thauer RK. Novel formaldehyde-activating enzyme in Methylobacterium extorquens AM1 required for growth on methanol. J Bacteriol. 2000 Dec;182(23):6645-50. DOI:10.1128/JB.182.23.6645-6650.2000 |
14. Cohen-Kupiec R, Marx CJ, and Leigh JA. Function and regulation of glnA in the methanogenic archaeon Methanococcus maripaludis. J Bacteriol. 1999 Jan;181(1):256-61. DOI:10.1128/JB.181.1.256-261.1999 |