User:Christopher H. Kennedy
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I am a new member of OpenWetWare!
Contact Info
- Christopher H. Kennedy, Ph.D., M.P.H.
- Lake Erie College of Osteopathic Medicine
- 1858 West Grandview Boulevard
- Erie, PA 16509-1025, USA
- Email me through OpenWetWare
I am the Director of the Cancer Biology Laboratory at the Lake Erie College of Osteopathic Medicine. I learned about OpenWetWare from an article in Scientific American, and I've joined because I'm a firm believer in the free exchange of scientific ideas. There are a number of projects that I have worked on over the years. However, a large amount of this work has not been published in scientific journals. Therefore, I am interested in sharing my ideas and unpublished data via OpenWetWare. I have a significant amount of experience in the field of Free Radical Biology. Therefore, I hope to be able to make a contribution to this field of science through this forum.
Education
- 1988, PhD, Louisiana State University, Baton Rouge, LA, USA (Major - Organic Chemistry; Minor - Biochemistry)
- 2003, MPH, University of North Carolina, Chapel Hill, NC, USA (Environmental Sciences)
- 1983, BS, Edinboro University of Pennsylvania, Edinboro, PA, USA (Chemistry)
Research interests
- Molecular Markers of Oxidative Stress in Carcinogenesis
- Role of Genomic Instability in Carcinogenesis
- Effects of Complex Mixtures of Toxicants on Human Bronchial Epithelial Cells
Publications
- Kennedy CH, Pryor WA, Winston GW, and Church DF. Hydroperoxide-induced radical production in liver mitochondria. Biochem Biophys Res Commun. 1986 Dec 30;141(3):1123-9. DOI:10.1016/s0006-291x(86)80160-7 |
- Kennedy CH, Dyer JM, Church DF, Winston GW, and Pryor WA. Radical production in liver mitochondria by peroxidic tumor promoters. Biochem Biophys Res Commun. 1989 May 15;160(3):1067-72. DOI:10.1016/s0006-291x(89)80111-1 |
- Kennedy CH, Winston GW, Church DF, and Pryor WA. Benzoyl peroxide interaction with mitochondria: inhibition of respiration and induction of rapid, large-amplitude swelling. Arch Biochem Biophys. 1989 Jun;271(2):456-70. DOI:10.1016/0003-9861(89)90296-8 |
- Maples KR, Kennedy CH, Jordan SJ, and Mason RP. In vivo thiyl free radical formation from hemoglobin following administration of hydroperoxides. Arch Biochem Biophys. 1990 Mar;277(2):402-9. DOI:10.1016/0003-9861(90)90596-q |
- Kennedy CH and Mason RP. A reexamination of the cytochrome P-450-catalyzed free radical production from a dihydropyridine. Evidence of trace transition metal catalysis. J Biol Chem. 1990 Jul 15;265(20):11425-8.
- Rumyantseva GV, Kennedy CH, and Mason RP. Trace transition metal-catalyzed reactions in the microsomal metabolism of alkyl hydrazines to carbon-centered free radicals. J Biol Chem. 1991 Nov 15;266(32):21422-7.
- Kennedy CH, Church DF, Winston GW, and Pryor WA. tert-Butyl hydroperoxide-induced radical production in rat liver mitochondria. Free Radic Biol Med. 1992;12(5):381-7. DOI:10.1016/0891-5849(92)90087-w |
- Kennedy CH, Hatch GE, Slade R, and Mason RP. Application of the EPR spin-trapping technique to the detection of radicals produced in vivo during inhalation exposure of rats to ozone. Toxicol Appl Pharmacol. 1992 May;114(1):41-6. DOI:10.1016/0041-008x(92)90094-9 |
- Kennedy CH, Cohen KB, Bechtold WE, Chang IY, Eidson AF, Dahl AR, and Henderson RF. Effect of dose on the metabolism of 1,1,2,2-tetrabromoethane in F344/N rats after gavage administration. Toxicol Appl Pharmacol. 1993 Mar;119(1):23-33. DOI:10.1006/taap.1993.1040 |
- Kennedy CH, Bechtold WE, Chang IY, and Henderson RF. Effect of dose on the disposition of 2-ethoxyethanol after inhalation by F344/N rats. Fundam Appl Toxicol. 1993 Nov;21(4):486-91. DOI:10.1006/faat.1993.1124 |
- Benson JM, Chang IY, Cheng YS, Hahn FF, Kennedy CH, Barr EB, Maples KR, and Snipes MB. Particle clearance and histopathology in lungs of F344/N rats and B6C3F1 mice inhaling nickel oxide or nickel sulfate. Fundam Appl Toxicol. 1995 Dec;28(2):232-44. DOI:10.1006/faat.1995.1164 |
- Kennedy CH, Mitchell CE, Fukushima NH, Neft RE, and Lechner JF. Induction of genomic instability in normal human bronchial epithelial cells by 238Pu alpha-particles. Carcinogenesis. 1996 Aug;17(8):1671-6. DOI:10.1093/carcin/17.8.1671 |
- Belinsky SA, Swafford DS, Middleton SK, Kennedy CH, and Tesfaigzi J. Deletion and differential expression of p16INK4a in mouse lung tumors. Carcinogenesis. 1997 Jan;18(1):115-20. DOI:10.1093/carcin/18.1.115 |
- Hussain SP, Kennedy CH, Amstad P, Lui H, Lechner JF, and Harris CC. Radon and lung carcinogenesis: mutability of p53 codons 249 and 250 to 238Pu alpha-particles in human bronchial epithelial cells. Carcinogenesis. 1997 Jan;18(1):121-5. DOI:10.1093/carcin/18.1.121 |
- Kennedy CH, Cueto R, Belinsky SA, Lechner JF, and Pryor WA. Overexpression of hMTH1 mRNA: a molecular marker of oxidative stress in lung cancer cells. FEBS Lett. 1998 Jun 5;429(1):17-20. DOI:10.1016/s0014-5793(98)00505-5 |
- Jaiswal AS, Kennedy CH, and Narayan S. A correlation of APC and c-myc mRNA levels in lung cancer cell lines. Oncol Rep. 1999 Nov-Dec;6(6):1253-6. DOI:10.3892/or.6.6.1253 |
- Catallo WJ, Kennedy CH, Henk W, Barker SA, Grace SC, and Penn A. Combustion products of 1,3-butadiene are cytotoxic and genotoxic to human bronchial epithelial cells. Environ Health Perspect. 2001 Sep;109(9):965-71. DOI:10.1289/ehp.01109965 |
- Kennedy CH, Pass HI, and Mitchell JB. Expression of human MutT homologue (hMTH1) protein in primary non-small-cell lung carcinomas and histologically normal surrounding tissue. Free Radic Biol Med. 2003 Jun 1;34(11):1447-57. DOI:10.1016/s0891-5849(03)00176-x |