I am a postdoctoral fellow in Gisela Storz's group at the National Institute of Child Health and Human Development. My research currently focuses on studying the regulatory characteristics of bacterial small RNAs in stress responses. Prior to joining the Storz group, I was a graduate student in Christina Smolke's group at Caltech.
I am interested in the regulatory capacity of RNA and how RNA can be exploited to program biological systems. RNA is capable of encoding diverse regulatory functions and is now known to be a critical regulator in all three domains of life. In examples ranging from riboswitches in bacteria to microRNAs in animals, regulatory RNAs orchestrate processes ranging from metabolism to development. However, our knowledge of the regulatory properties and roles played by these RNAs is still developing. In my research, I hope to better understand the natural utilization of RNA and translate insights into the programming of biological systems. By exploiting the natural utilization of RNA, I aim to implement RNA in ways already discovered and refined through evolution.
- Beisel CL and Smolke CD. Design principles for riboswitch function. PLoS Comput Biol. 2009 Apr;5(4):e1000363. DOI:10.1371/journal.pcbi.1000363 |
- Bayer TS, Hoff KG, Beisel CL, Lee JJ, and Smolke CD. Synthetic control of a fitness tradeoff in yeast nitrogen metabolism. J Biol Eng. 2009 Jan 2;3:1. DOI:10.1186/1754-1611-3-1 |
- Beisel CL, Bayer TS, Hoff KG, and Smolke CD. Model-guided design of ligand-regulated RNAi for programmable control of gene expression. Mol Syst Biol. 2008;4:224. DOI:10.1038/msb.2008.62 |
Beisel CL, Dowd MK, and Reilly PJ. Conformational analysis of gossypol and its derivatives by molecular mechanics. J Mol Struct THEOCHEM 2005; 730 51-58.
- Judice TN, Nelson NC, Beisel CL, Delimont DC, Fritzsch B, and Beisel KW. Cochlear whole mount in situ hybridization: identification of longitudinal and radial gradients. Brain Res Brain Res Protoc. 2002 Feb;9(1):65-76. DOI:10.1016/s1385-299x(01)00138-6 |