User:Bryan Downie

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Contact Info

Bryan Downie (an artistic interpretation)

I work in the MBNS Department at the Max Planck Institute of Experimental Medicine. I learned about OpenWetWare while web searching for protocols.

I'm currently examining the relationship between ion channels and tumor development, focusing specifically on the role of the potassium channel Eag1.


  • 2009, PhD of cell biology, University of Göttingen, Germany
  • 2005, Diploma, University of Göttingen, Germany
  • 2004, B.S. in Neurobiology, Univ of Washington, Seattle

Research interests

  1. Ion channels and cancer
  2. Nervous system vascularization
  3. Cellular signal transduction


  1. Downie BR, Sánchez A, Knötgen H, Contreras-Jurado C, Gymnopoulos M, Weber C, Stühmer W, and Pardo LA. Eag1 expression interferes with hypoxia homeostasis and induces angiogenesis in tumors. J Biol Chem. 2008 Dec 26;283(52):36234-40. DOI:10.1074/jbc.M801830200 | PubMed ID:18927085 | HubMed [Paper1]
  2. Weber C, Mello de Queiroz F, Downie BR, Suckow A, Stühmer W, and Pardo LA. Silencing the activity and proliferative properties of the human EagI Potassium Channel by RNA Interference. J Biol Chem. 2006 May 12;281(19):13030-7. DOI:10.1074/jbc.M600883200 | PubMed ID:16537547 | HubMed [Paper2]
All Medline abstracts: PubMed | HubMed

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