User:Antonio D. Konitsiotis
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- Antonio D. Konitsiotis
- Imperial College London
- Division of Molecular Medicine, NHLI
- Sir Alexander Fleming Building
- 2nd Floor, Desk 7
- South Kensington Campus
- SW7 2AZ
- London, UK
- Email me through OpenWetWare
Antonio Konitsiotis is a research associate in the Molecular Medicine Section of the National Heart and Lung Institute, Imperial College London.
Antonio graduated in 2005 from the University of London with a first class honours degree in Biology (BScHons). He joined Dr. Birgit Leitinger's lab at Imperial College in 2005 and embarked on a 4-year research Masters (MRes) plus PhD degree in Molecular Medicine funded by the Molecular Medicine Section (then Biomedical Sciences).
His PhD research concentrated on understanding the molecular interactions of the receptor tyrosine kinase Discoidin Domain Receptor 2 (DDR2) with collagen, and identified the first amino acid motif on collagen to which DDR2 binds, as well as identifying amino acids that were critical for binding. The paper reporting this work was chosen as paper of the week by the Journal of Biological Chemistry (2008, 283: 6861-6868). He was awarded his PhD in September 2010.
His current research is focused on pancreatic cancer, and understanding the role of the Hedgehog (Hh) pathway in development of the disease. Specifically, he is examining the role of Hedgehog Acyltransferase (Hhat) in pancreatic cancer, an important protein in the post-translational palmitoylation of Hh proteins. The ultimate goal of the research is to develop novel therapies for pancreatic cancer that target Hhat. This work is funded by the Pancreatic Cancer Research Fund (www.pcrf.org.uk) and is headed by Professor Tony Magee and Dr. Ed Tate at Imperial College London.
- 2006-2010, PhD in Molecular Medicine, Imperial College London
- 2005-2006, MRes in Biomedical sciences, Imperial College London
- 2002-2005, BSc(Hons), Royal Holloway University of London
- Cancer Biology
- Hedgehog protein signalling
- Molecular Biology
- of high affinity binding motifs for the discoidin domain receptor DDR2 in collagen. 2008, JBC 283(11),6861-8. pmid=18201965
- JACOB F and MONOD J. Genetic regulatory mechanisms in the synthesis of proteins. J Mol Biol. 1961 Jun;3:318-56.
leave a comment about a paper here
- Mark Ptashne. A genetic switch. Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory Press, 2004. ISBN:0879697164