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Updated 2018/05/03

Journal articles


  1. 37. T. Wang, et al., Engineering the transcriptional and translational machinery for biotechnology application, Mol. biotechnol., submitted.


  1. 36. T. Wang*, C. Liang, Y. Sun, W. Gao, X. Luo, Q. Gao, R. Li, S. Fu, H. Xu, T. He, H. Yuan, (2019) Strategical isolation of efficient chicken feather degrading bacterial strains from tea plantation soil sample, International Microbiology, 22(2):227-237. or
  2. 35. T. Wang#*, X. Qin#, C. Liang, H. Yuan*, (2018) Engineering substrate channeling in biosystems for improved efficiency, The Journal of Chemical Technology and Biotechnology, 93(12):3364-3373.
  3. 34. C. Liang, Z. Liu, C. Liu, Y. Li, H. Yuan, T. Wang*, (2018) Cook your samples: the application of microwave irradiation in speeding up biological processes, Mol. Biotechnol., 60(3):236-244.


  1. 33.N. Zhang, H.Guo, W. Zheng, T.Wang, P. Wang, X. Ma (2016) Design and screening of a chimeric Survivin-specific nanobody and its anticancer activities in vitro, Anti-cancer drug, 27(9):839-847.
  2. 32.S.Wu, Y. Zhou, T. Wang, H. Too Daniel I. C. Wang, Z. Li, Highly Regio- and Enantioselective Multiple Oxy- and Amino-functionalization of Alkenes by Modular Cascade Biocatalysis, Nature Comm., 7:11917.
  3. 31.D. Liu, N.Zhang, W.Zheng, H. Guo, X.Wang, T. Wang, P. Wang, X. Ma (2016) A novel method of efficient preparation to mucosal adjuvant E. coli heat-labile enterotoxin mutant (LTm) by artificial self-assembly in vitro, Appl. Biochem Biotech.,179 (1):33-45.
  4. 30.D. Liu, N.Zhang, W.Zheng, H. Guo, T. Wang, P. Wang, X. Ma (2016) Discovery of cell-penetrating function of LTA2 peptide derived from subunit of E.coli heat-labile enterotoxin, Appl. Microbiol. Biotech.,100 (11):5079-5088.
  5. 29.S.Cui#, T. Wang#, H. Hu, l. Liu, A.Song, H. Chen, Investigating the expression profiles of F10 and G11 xylanases 1 from Aspergillus niger A09 with qPCR, Can. J. Microbiol., 62(9):744-752.(#equal contributors)
  6. 28.X.Zhang, F.Hu, X. Ma, T. Wang, P.Wang, X. Wang, Design, construction, characterization and preliminary activity research of universal influenza virus vaccine (Flu@uV) delivered by Hepatitis B virus core protein (HBc-VLP), China Biotechnology, 2016, 36(2): 7-15.[张旭凡,胡发彪,马兴元,王天文,王平,由乙肝病毒核心蛋白(HBc-VLP)递载的流感通用疫苗Flu@uV设计构建、表征及初步活性研究,中国生物工程杂志]


  1. 27.Wang T, Ma F, Ma X, Wang P (2015) Spatially-programmed assembling of oxidoreductases with single-stranded DNA for cofactor-required reactions, Appl. Microbiol. Biotech. 99 (8):3469–3477. PMID:25363557.


  1. 26.Wang T, Ma F, Ma X, Wang P (2014) Identification and characterization of protein encoded by orf382 as L-threonine dehydrogenase. J Microbiol Biotechnol 24:748–755. PMID: 24651643.
  2. 25.Lin N, Zheng W, Li L, Liu H, Wang T., Wang P, Ma X (2014) A novel system enhancing the endosomal escapes of peptides promotes Bak BH3 peptide inducing apoptosis in lung cancer A549 cells. Target Oncol 9:163–170. PMID: 23740403


  1. 24.Shi L, Tang L, Ma X, Wang T, Ma F, Wang P (2013) Efficient preparation of an anti-tumor protein TmSm by reversible phase transition of ELPs and self-cleaving function of Intein. China Biotechnol. 33(10):89-95.[In Chinese](石磊; 唐莉莉; 马兴元; 王天文; 马飞; 王平,利用类弹性蛋白可逆相变和内含肽自切割功能高效制备TmSm抗肿瘤蛋白,中国生物工程学报,2013,33(10):89-95.)
  2. 23.Zhang C, Zhang J, Kang Z, Du G, Yu X, Wang T, Chen J (2013) Enhanced production of L-phenylalanine in Corynebacterium glutamicum due to the introduction of Escherichia coli wild-type gene aroH. J Ind Microbiol Biotechnol, 40(6):643–651.PMID:23526182.
  3. 22.Hu Y., Wang T., Du G., Chen J. (2013) Decreased acetic acid synthesis and enhanced L-phenylalanine production by E.coli WSH-Z06 (pAP-B03) using three stage glucose feeding strategy, Ind. Microbiol., 43(1):6-10.[In Chinese](胡云,王天文,堵国成,陈坚,利用三阶段葡萄糖添加策略减少乙酸合成并促进重组大肠杆菌生产L-苯丙氨酸,工业微生物,2013:43(1):6-10.)
  4. 21.Wang J., Zhou H., Li J., Wang T., Liu L., Du G., Chen J. (2013) Influence of feeding L-tyrosine during induction phase on production of L-phenylalanine in fed-batch cultivation by recombinant Escherichia coli, Ind. Microbiol., 43(1): 24-29.[In Chinese] (王静, 周海岩, 李江华, 王天文, 刘龙, 堵国成, 陈坚,酪氨酸流加方式对重组大肠杆菌发酵生产L-苯丙氨酸的影响, 工业微生物, 2013, 43(1): 24-29.)


  1. 20. Wang T, Li A, Ma X, Du G, Chen J (2012) A simple and universal method to express protein in unfused form. Protein Pept Lett 19(9):930–933. PMID:22316309.
  2. 19. Wang T, Ma X, Du G, Chen J (2012) Overview of regulatory strategies and molecular elements in metabolic engineering of bacteria. Mol Biotechnol 52(3):300-388. PMID: 22359157.
  3. 18. Wang T, Ma X, Zhu H, Li A, Du G, Chen J (2012) Available methods for assembling expression cassettes for synthetic biology. Appl Microbiol Biotechnol. 93(5):1853-1863. PMID: 22311648.
  4. 17. Qiu X, Wang T, Zhong X, Du G, Chen J (2012) Screening and characterization of an aerobic nitrifying-denitrifying bacterium from activated sludge. Biotechnol Bioproc E. 17(2):353-360. DOI 10.1007/s12257-011-0467-y
  5. 16. Xu Y, Zheng W, Wang T, Wang P, Zhu L, Ma X (2012) Genetic protein TmSm(T34A) enhances sensitivity of chemotherapy to breast cancer cell lines as a synergistic drug to doxorubicin. Biomed Pharmacother 66(5):368-372. PMID:22560635


  1. 15.Zhou H, Liao X, Liu L, Wang T, Du G, Chen J (2011) Enhanced L-phenylalanine production by recombinant Escherichia coli BR-42 (pAP-B03) resistant to bacteriophage BP-1 via a two-stage feeding approach. J Ind Microbiol Biotechnol. 38(9):1219-1227. [Co-corresponding author], PMID:21104105.
  2. 14.Zhou H., Liu L., Wang T., Du G., Chen J., (2011) Recent advances in L-phenylalanine production by microbial fermentation, Ind. Microbiol.,41(3):90-98. [In Chinese](周海岩 刘龙 王天文 堵国成 陈坚,微生物发酵法生产L-苯丙氨酸的研究进展,工业微生物,2011,41(3):90-98.)


  1. 13. Wang T, Hu Y, Liao X, Du G, Chen J, Xu J (2010) Anti-oxidative stress and beyond: multiple functions of the protein glutathionylation. Protein Pept Lett. 17(10):1234-1244. [Co-1st and -corresponding author], PMID:20394582.
  2. 12. Zhou H, Liao X, Wang T, Du G, Chen J (2010) Enhanced l-phenylalanine biosynthesis by co-expression of pheA(fbr) and aroF(wt). Bioresour Technol. 101(11):4151-4156. [Co-corresponding author], PMID:20137911.


  1. 11. Wang T, Qiu A, Meng F, Zhou H (2009) Changing the metal binding specificity of superoxide dismutase from Thermus thermophilus HB-27 by a single mutation. Mol Biotechnol. 42(2):146-153. PMID:19191037.


  1. 10. Wang T, Zhu H, Ma X, Fei Z, Ma Y, Wei D (2006) Enhancing enzymatic activity of penicillin G acylase by coexpressing pcm gene. Appl Microbiol Biotechnol 72(5):953-958. PMID:16550378.
  2. 9. Wang T, Zhu H, Ma X, Ma Y, Wei D (2006) Structure-based stabilization of an enzyme: the case of penicillin acylase from Alcaligenes faecalis. Protein Pept Lett. 13(2):177-183. PMID:16472081.
  3. 8. Wang T, Zhu H, Ma X, Zhang T, Ma Y, Wei D (2006) Mutant library construction in directed molecular evolution: casting a wider net. Mol Biotechnol. 34(1):55-68. PMID:16943572.
  4. 7. Zhu H, Wang T, Sun S, Shen Y, Wei D (2006) Chromosomal integration of the Vitreoscilla hemoglobin gene and its physiological actions in Tremella fuciformis. Appl Microbiol Biotechnol. 72(4):770-776. PMID:16501972.
  5. 6. Ma X, Zheng W, Wang T, Wei D, Ma Y (2006) Optimization and high-level expression of a functional GST-tagged rHLT-B in Escherichia coli and GM1 binding ability of purified rHLT-B. J Microbiol. 44(3):293-300. PMID:16820759.
  6. 5. Ma X, Zheng W, Wang T (2006) Leukocyte function-associated antigen-1: structure, function and application prospects. Protein Pept Lett. 13(4):397-400. PMID: 16712517.
  7. 4. Zhu H, Pan R, Wang T, Shen Y, Wei D (2006) Functional solubilization of aggregation-prone TRAIL protein facilitated by coexpressing with protein isoaspartate methyltranferase. Appl Microbiol Biotechnol. 72(5):1033-1038. PMID:16575568.
  8. 3. Ma X, Zheng W, Wei D, Ma Y, Wang T, Wang J, Liu Q, Yang S (2006) High-level expression, purification and pro-apoptosis activity of HIV-TAT-survivin (T34A) mutant to cancer cells in vitro. J Biotechnol. 123(3):367-378. PMID:16406157.
  9. 2. Ma X, Zheng W, Wei D, Ma Y, Wang T, Wang J, Liu Q, Yang S (2006) Construction, expression, and purification of HIV-TAT-survivin (T34A) mutant: a pro-apoptosis protein in Escherichia coli. Protein Expr Purif. 47(1):36-44. PMID: 16260148.


  1. 1. Zheng W, Ma X, Wei D, Wang T, Ma Y, Yang S (2005) Molecular cloning and bioinformatics analysis of a novel spliced variant of survivin from human breast cancer cells. DNA Seq. 16(5):321-328. PMID:16329164.


  1. . Z.Li, T.Wang, J.Zhang,Preparation of Enantiopure Vicinal Diols and Alpha-Hydroxyketones from Racemic and Meso-Epoxides by Tandem Biocatalysis via Enantioselective Hydrolysis and Oxidations, International Patent Application No. PCT/SG2014/000299.
  2. . 授权发明专利:大肠杆菌热敏毒素B亚单位的真核表达方法,中国专利授权号:ZL 200510027957.6,发明人:魏东芝, 马兴元, 郑文云, 王天文, 罗 晨, 马昱澍;
  3. . 授权发明专利:一种用于原核分泌、融合表达大肠杆菌热敏毒素B亚单位的载体, 中国专利授权号:ZL200510028084.0,发明人:魏东芝, 马兴元,王天文, 郑文云;
  4. . 授权发明专利:一种ssDNA-蛋白质酶法交联方法,公开(公告)号:CN103361321; 发明人:王天文,马兴元,马飞,王平;(授权公告日:2015.2.28,ZL2013 1 0261812.7, 第1589468号)
  5. . 发明专利:一种微生物发酵生产L-苯丙氨酸的方法,公开(公告)号: CN102399835;发明人:陈坚,张传志,堵国成,康振,周景文,王天文;
  6. . 发明专利:一种产碱性蛋白酶基因工程菌及其应用,公开(公告)号: CN102174453;发明人: 陈坚,张传志,堵国成,王天文;
  7. . 发明专利:一株好氧除磷菌——恶臭假单胞菌WSH1002及其应用,公开(公告)号:CN102181375;发明人:郑展望,陈坚,堵国成,仲小敏,王天文,徐甦,刘斌,丁青松;
  8. . 发明专利:一株好氧反硝化菌及其筛选方法和应用,公开(公告)号:CN102115719;发明人:陈坚,堵国成,王天文,邱晓帆,仲小敏;
  9. . 发明专利:一种生物法生产l-苯丙氨酸的方法, 公开(公告)号: CN101984066;发明人:陈坚,堵国成,王天文,胡云;
  10. . 发明专利:一种抗噬菌体L-苯丙氨酸生产菌及选育方法和其应用,公开(公告)号:CN102010847;发明人:陈坚,堵国成,周海岩,廖鲜艳,薛晓驰,王天文;
  11. . 发明专利:重组耐高温超氧化物岐化酶的高密度发酵与纯化工艺,公开(公告)号:CN101275144;发明人:孟凡国,夏勇,王天文,胡卫江,周海梦。