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Updated 2020/06/07, # equal contributor, * corresponding author

Journal articles

Year 2020

1. Qiuju Zhou#, Tianwen Wang#, Can Wang, Zheng Wang, Yanan Wang, Pei Li, Ruihua Cai, Meng Sun, Hongyu Yuan and Lei Nie*, 2020, Synthesis and characterization of silver nanoparticles-doped hydroxyapatite/alginate microparticles with promising histocompatibility and antibacterial properties, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 585124081. DOI:, 【indexed】

2. Tianwen Wang, Chen Liang, Yafei An, Sa Xiao, Hongju Xu, Mengyuan Zheng, Lu Liu, Gaozhan Wang and Lei Nie*, 2020, Engineering the translational machinery for biotechnology applications, Molecular Biotechnology, 62(4): 219-227. DOI:, 【indexed】

3. Tianwen Wang, Chen Liang, Hongju Xu, Yafei An, Sa Xiao, Mengyuan Zheng, Lu Liu and Lei Nie*, 2020, Incorporation of nonstandard amino acids into proteins: principles and applications, World Journal of Microbiology and Biotechnology, 36(4): 60. DOI:, 【indexed】

4. Tianwen Wang, Hui Li, Chen Liang, Shiwei Sun, Ao Liu and Hu Zhu*, 2020, The high-efficient production of phelligridin LA by Inonotus baumii with an integrated fermentation-separation process, Bioprocess and Biosystems Engineering, 43(7):1141-1151. DOI:, 【indexed】

5. Tianwen Wang, Ningning Yang, Chen Liang, Hongju Xu, Yafei An, Sa Xiao, Mengyuan Zheng, Lu Liu, Gaozhan Wang and Lei Nie*, 2020, Detecting protein-protein interaction based on protein fragment complementation assay, Current Protein and Peptide Science, 21(6):598-610. DOI:, 【indexed】

6. Tianwen Wang*, Chen Liang, Yajing Hou, Mengyuan Zheng, Hongju Xu, Yafei An, Sa Xiao, Lu Liu and Shuaibin Lian, 2020, Small design from big alignment: engineering protein with multiple sequence alignment as the starting point, Biotechnology Letters, 42(8): 1305–1315. DOI:, 【indexed】

7. Shuaibin Lian, Zixiao Liu, Yongjie Zhou, Jiantao Guo, Ke Gong and Tianwen Wang*, 2020, The differential expression patterns and co-expression networks of paralogs as an indicator of the TNM stages of lung adenocarcinoma and squamous cell carcinoma, Genomics, 112(6):4115-4124. DOI:, 【indexed】

8. Tianwen Wang, Hui Li, Chen Liang, Shiwei Sun, Ao Liu and Hu Zhu*, 2020, Purification and characterization of a novel antioxidant Phelligridin LA produced by Inonotus baumii, Journal of Chemical Technology and Biotechnology, 95(9): 283-294. DOI:, 【indexed】

9. Tianwen Wang, Fang Zhang, Kehui Hu, Rui Zhao, Yi Sun, Constantinus Politis, Shoufeng Yang, and Lei Nie*, 2020, Polyvinyl alcohol/sodium alginate hydrogels incorporated with silver nanoclusters via green tea extract for antibacterial applications, Designed Monomers and Polymers, 23(1):118-133. DOI:, 【indexed】

10. Lei Nie, Mengjuan Hou, Tianwen Wang, Meng Sun, Ruixia Hou, 2020, Nanostructured selenium‑doped biphasic calcium phosphate with in situ incorporation of silver for antibacterial applications, Scientific Reports, 10:13738. DOI:, 【indexed】

11. Tianwen Wang, Shiwei Sun, Chen Liang, Hui Li, Ao Liu and Hu Zhu*, 2020, Effective isolation of antioxidant Phelligridin LA from the fermentation broth of Inonotus baumii by microporous resin, Bioprocess and Biosystems Engineering, 43(11):2095–2106. DOI:, 【indexed】

12. Tianwen Wang, Chen Liang, Wenxiu Xing, Wanyu Wu, Yajing Hou, Linfang Zhang, Sa Xiao, Hongju Xu, Yafei An, Mengyuan Zheng, Lu Liu and Lei Nie*, 2020, Transcriptional factor engineering in microbes for industrial biotechnology, Journal of Chemical Technology and Biotechnology, 95(12):3071-3078. DOI:, 【indexed】

13. Tianwen Wang, Chen Liang, Mengyuan Zheng, Lu Liu, Yafei An, Hongju Xu, Sa Xiao and Lei Nie*, 2020, Ribosome hibernation as a stress response of bacteria, Protein and Peptide Letters, 27(11):1082-1091. DOI:, 【indexed】

14. Zixiao Liu#, Yanting Han#, Yongjie Zhou, Tianwen Wang*, Shuaibin Lian*, Hongyu Yuan*, 2020, Transcriptomic analysis of tea plant (Camellia sinensis) revealed the co-expression network of 4111 paralogous genes and biosynthesis of quality-related key metabolites under multiple stresses, Genomics, OnlineFirst DOI:

15. Tianwen Wang*, Chen Liang, Sa Xiao, Li Li, Hongju Xu, Yafei An, Mengyuan Zheng and Lu Liu, 2020, A thermostable aluminum-tolerant protease produced by feather-degrading Bacillus thuringiensis isolated from tea plantation, Protein and Peptide Letters, OnlineFirst DOI:

16. Tianwen Wang et al., Advances on knowledge discovery of protein via bioinformatics-driven sequence analysis, Manuscript preparation

Year 2019

16. Tianwen Wang*, Chen Liang, Yan Sun, Wanru Gao, Xinqi Luo, Qian Gao, Rui Li, Shuang Fu, Hongju Xu, Ting He and Hongyu Yuan, 2019, Strategical isolation of efficient chicken feather-degrading bacterial strains from tea plantation soil sample, International Microbiology, 22(2): 227-237. DOI:

Year 2018

17. Chen Liang, Ziwei Liu, Chaoping Liu, Yimeng Li, Hongyu Yuan and Tianwen Wang*, 2018, Cook your samples: the application of microwave irradiation in speeding up biological processes, Molecular Biotechnology, 60(3): 236-244. DOI:

18. Tianwen Wang, Xin Qin, Chen Liang and Hongyu Yuan*, 2018, Engineering substrate channeling in biosystems for improved efficiency, The Journal of Chemical Technology and Biotechnology, 93(12): 3364-3373. DOI:

Year 2016

19. Xufan Zhang, Fabiao Hu, Xingyuan Ma*, Tianwen Wang, Ping Wang and Xiaoli Wang, 2016, Design, construction, characterization and preliminary activity research of universal influenza virus vaccine (Flu@uV) delivered by Hepatitis B virus core protein (HBc-VLP), China Biotechnology, 36(2): 7-15. DOI:

20. Na Zhang, Hua Guo, Wenyun Zheng, Tianwen Wang and Xingyuan Ma*, 2016, Design and screening of a chimeric survivin-specific nanobody and its anticancer activities in vitro, Anticancer Drugs, 27(9): 839-47. DOI:

21. Shuke Wu, Yi Zhou, Tianwen Wang, Heng Phon Too, Daniel I.C. Wang and Zhi Li*, 2016, Highly regio- and enantioselective multiple oxy- and amino- functionalizations of alkenes by modular cascade biocatalysis, Nature Communications, 711917. DOI:

22. Di Liu, Na Zhang, Wenyun Zheng, Hua Guo, Xiaoli Wang, Tianwen Wang, Ping Wang* and Xingyuan Ma*, 2016, A novel method for efficient preparation of mucosal adjuvant Escherichia coli heat-labile enterotoxin mutant (LTm) by artificially assisted self-assembly in vitro, Applied Biochemistry and Biotechnology, 179(1): 33-45. DOI:

23. Di Liu, Huo Guo, Wenyun Zheng, Na Zhang, Tianwen Wang, Ping Wang and Xingyuan Ma*, 2016, Discovery of the cell-penetrating function of A2 domain derived from LTA subunit of Escherichia coli heat-labile enterotoxin, Applied Microbiology Biotechnology, 100(11): 5079-88. DOI:

24. Shixiu Cui#, Tianwen Wang#, Hong Hu, Liangwei Liu, Andong Song and Hongge Chen*, 2016, Investigating the expression of F10 and G11 xylanases in Aspergillus niger A09 with qPCR, Canadian Journal of Microbiology, 62(9): 744-52. DOI:

Year 2015

25. Tianwen Wang, Fei Ma, Xingyuan Ma and Ping Wang*, 2015, Spatially programmed assembling of oxidoreductases with single-stranded DNA for cofactor-requiring reactions, Applied Microbiology and Biotechnology, 99(8): 3469-77. DOI:

Year 2005-2014

26. Fei Ma, Tianwen Wang, Xingyuan Ma* and Ping Wang*, 2014, Identification and characterization of protein encoded by orf382 as L-threonine dehydrogenase, Journal of Microbiology and Biotechnology, 24(6): 748-55. DOI:

27. Nanjing Lin, Wenyun Zheng, Linfeng Li, Hui Liu, Tianwen Wang, Ping Wang and Xingyuan Ma*, 2014, A novel system enhancing the endosomal escapes of peptides promotes Bak BH3 peptide inducing apoptosis in lung cancer A549 cells, Targeted Oncology, 9(2): 163-70. DOI:

28. Chuanzhi Zhang, Junli Zhang, Zhen Kang*, Guocheng Du, Xiaobin Yu, Tianwen Wang and Jian Chen*, 2013, Enhanced production of L-phenylalanine in Corynebacterium glutamicum due to the introduction of Escherichia coli wild-type gene aroH, Journal of Industrial Microbiology and Biotechnology, 40(6): 643-51. DOI:

29. Jing Wang, Haiyan Zhou, Jianghua Li, Tianwen Wang, Long Liu*, Guocheng Du and Jian Chen, 2013, Influence of feeding L-tyrosine during induction phase on production of L-phenylalanine in fed-batch cultivation by recombinant Escherichia coli, Industrial Microbiology, 43(1): 24-29. DOI:inChs, Unavailable

30. Lei Shi, Lili Tang, Xingyuan Ma*, Tianwen Wang and Ping Wang, 2013, Efficient preparation of an anti-tumor protein TmSm by reversible phase transition of ELPs and self-cleaving function of intein, China Biotechnol.(In Chs), 33(10): 89-95. DOI:

31. Yun Hu, Tianwen Wang*, Guocheng Du and Jian Chen, 2013, Decreased acetic acid synthesis and enhanced L-phenylalanine production by E.coli WSH-Z06 (pAP-B03) using three stage glucose feeding strategy, Industrial Microbiology, 43(1): 6-10. DOI:inChs, Unavailable

32. Xiaofan Qiu, Tianwen Wang, Xiaomin Zhong, Guocheng Du* and Jian Chen*, 2012, Screening and characterization of an aerobic nitrifying-denitrifying bacterium from activated sludge, Biotechnology and Bioprocess Engineering, 17(2): 353-360. DOI:

33. Tianwen Wang, Aitao Li, Xingyuan Ma*, Guocheng Du and Jian Chen, 2012, A simple and universal method to express protein in unfused form, Protein and Peptide Letters, 19(9): 930-3. DOI:

34. Tianwen Wang, Xingyuan Ma*, Guocheng Du and Jian Chen, 2012, Overview of regulatory strategies and molecular elements in metabolic engineering of bacteria, Molecular Biotechnology, 52(3): 300-8. DOI:

35. Tianwen Wang, Xingyuan Ma*, Hu Zhu, Aitao Li, Guocheng Du and Jian Chen, 2012, Available methods for assembling expression cassettes for synthetic biology, Applied Microbiology and Biotechnology, 93(5): 1853-63. DOI:

36. Yuxin Xu, Wenyun Zheng, Tianwen Wang, Ping Wang, Ling Zhu and Xingyuan Ma*, 2012, Genetic protein TmSm(T34A) enhances sensitivity of chemotherapy to breast cancer cell lines as a synergistic drug to doxorubicin, Biomedicine & Pharmacotherapy, 66(5): 368-72. DOI:

37. Haiyan Zhou, Xianyan Liao, Long Liu, Tianwen Wang*, Guocheng Du* and Jian Chen, 2011, Enhanced L-phenylalanine production by recombinant Escherichia coli BR-42 (pAP-B03) resistant to bacteriophage BP-1 via a two-stage feeding approach, Journal of Industrial Microbiology and Biotechnology, 38(9): 1219-27. DOI:

38. Haiyan Zhou, Long Liu, Tianwen Wang*, Guocheng Du and Jian Chen, 2011, Recent advances in L-phenylalanine production by microbial fermentation, Industrial Microbiology, 41(3): 90-98. DOI:inChs, Unavailable

39. Haiyan Zhou, Xianyan Liao, Tianwen Wang, Guocheng Du* and Jian Chen*, 2010, Enhanced l-phenylalanine biosynthesis by co-expression of pheA(fbr) and aroF(wt), Bioresources Technology, 101(11): 4151-6. DOI:

40. Yun Hu, Tianwen Wang*, Xianyan Liao, Guocheng Du*, Jian Chen and Jigai Xu, 2010, Anti-oxidative stress and beyond: multiple functions of the protein glutathionylation, Protein and Peptide Letters, 17(10): 1234-44. DOI:

41. Tianwen Wang*, Aidong Qiu, Fanguo Meng and Haimeng Zhou, 2009, Changing the metal binding specificity of superoxide dismutase from Thermus thermophilus HB-27 by a single mutation, Molecular Biotechnology, 42(2): 146-53. DOI:

42. Hu Zhu, Tianwen Wang, Shujing Sun, Yaling Shen* and Dongzhi Wei*, 2006, Chromosomal integration of the Vitreoscilla hemoglobin gene and its physiological actions in Tremella fuciformis, Applied Microbiology and Biotechnology, 72(4): 770-6. DOI:

43. Hu Zhu, Ruojun Pan, Tianwen Wang, Yaling Shen* and Dongzhi Wei*, 2006, Functional solubilization of aggregation-prone TRAIL protein facilitated by coexpressing with protein isoaspartate methyltranferase, Applied Microbiology and Biotechnology, 72(5): 1033-8. DOI:

44. Tianwen Wang, Hu Zhu, Xingyuan Ma, Ting Zhang, Yushu Ma and Dongzhi Wei*, 2006, Mutant library construction in directed molecular evolution: casting a wider net, Molecular Biotechnology, 34(1): 55-68. DOI:

45. Tianwen Wang, Hu Zhu, Xingyuan Ma, Yushu Ma and Dongzhi Wei*, 2006, Structure-based stabilization of an enzyme: the case of penicillin acylase from Alcaligenes faecalis, Protein and Peptide Letters, 13(2): 177-83. DOI:

46. Tianwen Wang, Hu Zhu, Xingyuan Ma, Zhuoya Fei, Yushu Ma and Dongzhi Wei*, 2006, Enhancing enzymatic activity of penicillin G acylase by coexpressing pcm gene, Applied Microbiology Biotechnology, 72(5): 953-8. DOI:

47. Xingyuan Ma, Wenyun Zheng, Dongzhi Wei*, Yushu Ma, Tianwen Wang, Jinzhi Wang, Qinghai Liu and Shengli Yang, 2006, High-level expression, purification and pro-apoptosis activity of HIV- TAT-survivin (T34A) mutant to cancer cells in vitro, Journal of Biotechnology, 123(3): 367-78. DOI:

48. Xingyuan Ma, Wenyun Zheng, Dongzhi Wei*, Yushu Ma, Tianwen Wang, Jinzhi Wang, Qinghai Liu and Shengli Yang, 2006, Construction, expression, and purification of HIV-TAT-survivin (T34A) mutant: a pro-apoptosis protein in Escherichia coli, Protein Expression and Purification, 47(1): 36-44. DOI:

49. Xingyuan Ma, Wenyun Zheng, Tianwen Wang, Dongzhi Wei* and Yushu Ma, 2006, Optimization and high-level expression of a functional GST-tagged rHLT-B in Escherichia coli and GM1 binding ability of purified rHLT-B, Journal of Microbiology, 44(3): 293-300. DOI:English, Unavailable

50. Xingyuan Ma, Wenyun Zheng* and Tianwen Wang, 2006, Leukocyte function-associated antigen-1: structure, function and application prospects, Protein and Peptide Letters, 13(4): 397-400. DOI:

51. Wenyun Zheng, Xingyuan Ma, Dongzhi Wei*, Tianwen Wang, Yushu Ma and Shengli Yang, 2005, Molecular cloning and bioinformatics analysis of a novel spliced variant of survivin from human breast cancer cells, DNA Sequences, 16(5): 321-8. DOI:


  1. . Z.Li, T.Wang, J.Zhang,Preparation of Enantiopure Vicinal Diols and Alpha-Hydroxyketones from Racemic and Meso-Epoxides by Tandem Biocatalysis via Enantioselective Hydrolysis and Oxidations, International Patent Application No. PCT/SG2014/000299.
  2. . 授权发明专利:大肠杆菌热敏毒素B亚单位的真核表达方法,中国专利授权号:ZL 200510027957.6,发明人:魏东芝, 马兴元, 郑文云, 王天文, 罗 晨, 马昱澍;
  3. . 授权发明专利:一种用于原核分泌、融合表达大肠杆菌热敏毒素B亚单位的载体, 中国专利授权号:ZL200510028084.0,发明人:魏东芝, 马兴元,王天文, 郑文云;
  4. . 授权发明专利:一种ssDNA-蛋白质酶法交联方法,公开(公告)号:CN103361321; 发明人:王天文,马兴元,马飞,王平;(授权公告日:2015.2.28,ZL2013 1 0261812.7, 第1589468号)
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