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Updated 2020/06/07, # equal contributor, * corresponding author

Journal articles

Year 2022

54. Ningning Yang,Siyuan Wang,Peng Ding,Shaolan Sun, Qianqian Wei, Hafez Jafari, Ling Wang, Yanting Han, Oseweuba Valentine Okorod, Tianwen Wang, Guicai Li, Amin Shavandi, Lei Nie, 2022, Magnesium-doped Biphasic Calcium Phosphate Nanoparticles with Incorporation of Silver: Synthesis, Cytotoxic and Antibacterial Properties, Materials Letters, 322:132478. DOI:

53. Changping Deng, Fabiao Hu, Zhangting Zhao, Yiwen Zhou, Yuping Liu, Tong Zhang, Shihui Li, Wenyun Zheng, Wenliang Zhang, Tianwen Wang*, Xingyuan Ma, 2022, The Establishment of Quantitatively Regulating Expression Cassette with sgRNA Targeting BIRC5 to Elucidate the Synergistic Pathway of Survivin with P-glycoprotein in Cancer Multi-drug Resistance, Frontiers in Cell and Developmental Biology, section Molecular and Cellular Oncology, 9:797005., 【indexed】

Year 2021

52. Tianwen Wang*, Chen Liang, Sa Xiao, Li Li, Hongju Xu, Yafei An, Mengyuan Zheng and Lu Liu, 2021, A thermostable aluminum-tolerant protease produced by feather-degrading Bacillus thuringiensis isolated from tea plantation, Protein and Peptide Letters, 28(5):563-572. DOI:, 【indexed】

51. Zixiao Liu#, Yanting Han#, Yongjie Zhou, Tianwen Wang, Shuaibin Lian*, Hongyu Yuan*, 2021, Transcriptomic analysis of tea plant (Camellia sinensis) revealed the co-expression network of 4111 paralogous genes and biosynthesis of quality-related key metabolites under multiple stresses, Genomics, 113(1):908-918. DOI:

50. Lei Nie, Ruijiao Zhang, Linfang Zhang, Mengyuan Ma, Congcong Li, Yi Zhang, Yafei An, Hongju Xu, Sa Xiao, Tianwen Wang*, 2021, Mutations in the regulatory regions result in increased streptomycin resistance and keratinase synthesis in Bacillus thuringiensis, Archives of Microbiology, 203(9):5387–5396. DOI:, 【indexed】

Year 2020

49. Qiuju Zhou#, Tianwen Wang#, Can Wang, Zheng Wang, Yanan Wang, Pei Li, Ruihua Cai, Meng Sun, Hongyu Yuan and Lei Nie*, 2020, Synthesis and characterization of silver nanoparticles-doped hydroxyapatite/alginate microparticles with promising histocompatibility and antibacterial properties, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 585124081. DOI:, 【indexed】

48. Tianwen Wang, Chen Liang, Yafei An, Sa Xiao, Hongju Xu, Mengyuan Zheng, Lu Liu, Gaozhan Wang and Lei Nie*, 2020, Engineering the translational machinery for biotechnology applications, Molecular Biotechnology, 62(4): 219-227. DOI:, 【indexed】

47. Tianwen Wang, Chen Liang, Hongju Xu, Yafei An, Sa Xiao, Mengyuan Zheng, Lu Liu and Lei Nie*, 2020, Incorporation of nonstandard amino acids into proteins: principles and applications, World Journal of Microbiology and Biotechnology, 36(4): 60. DOI:, 【indexed】

46. Tianwen Wang, Hui Li, Chen Liang, Shiwei Sun, Ao Liu and Hu Zhu*, 2020, The high-efficient production of phelligridin LA by Inonotus baumii with an integrated fermentation-separation process, Bioprocess and Biosystems Engineering, 43(7):1141-1151. DOI:, 【indexed】

45. Tianwen Wang, Ningning Yang, Chen Liang, Hongju Xu, Yafei An, Sa Xiao, Mengyuan Zheng, Lu Liu, Gaozhan Wang and Lei Nie*, 2020, Detecting protein-protein interaction based on protein fragment complementation assay, Current Protein and Peptide Science, 21(6):598-610. DOI:, 【indexed】

44. Tianwen Wang*, Chen Liang, Yajing Hou, Mengyuan Zheng, Hongju Xu, Yafei An, Sa Xiao, Lu Liu and Shuaibin Lian, 2020, Small design from big alignment: engineering protein with multiple sequence alignment as the starting point, Biotechnology Letters, 42(8): 1305–1315. DOI:, 【indexed】

43. Shuaibin Lian, Zixiao Liu, Yongjie Zhou, Jiantao Guo, Ke Gong and Tianwen Wang*, 2020, The differential expression patterns and co-expression networks of paralogs as an indicator of the TNM stages of lung adenocarcinoma and squamous cell carcinoma, Genomics, 112(6):4115-4124. DOI:, 【indexed】

42. Tianwen Wang, Hui Li, Chen Liang, Shiwei Sun, Ao Liu and Hu Zhu*, 2020, Purification and characterization of a novel antioxidant Phelligridin LA produced by Inonotus baumii, Journal of Chemical Technology and Biotechnology, 95(9): 283-294. DOI:, 【indexed】

41. Tianwen Wang, Fang Zhang, Kehui Hu, Rui Zhao, Yi Sun, Constantinus Politis, Shoufeng Yang, and Lei Nie*, 2020, Polyvinyl alcohol/sodium alginate hydrogels incorporated with silver nanoclusters via green tea extract for antibacterial applications, Designed Monomers and Polymers, 23(1):118-133. DOI:, 【indexed】

40. Lei Nie, Mengjuan Hou, Tianwen Wang, Meng Sun, Ruixia Hou, 2020, Nanostructured selenium‑doped biphasic calcium phosphate with in situ incorporation of silver for antibacterial applications, Scientific Reports, 10:13738. DOI:, 【indexed】

39. Tianwen Wang, Shiwei Sun, Chen Liang, Hui Li, Ao Liu and Hu Zhu*, 2020, Effective isolation of antioxidant Phelligridin LA from the fermentation broth of Inonotus baumii by microporous resin, Bioprocess and Biosystems Engineering, 43(11):2095–2106. DOI:, 【indexed】

38. Tianwen Wang, Chen Liang, Wenxiu Xing, Wanyu Wu, Yajing Hou, Linfang Zhang, Sa Xiao, Hongju Xu, Yafei An, Mengyuan Zheng, Lu Liu and Lei Nie*, 2020, Transcriptional factor engineering in microbes for industrial biotechnology, Journal of Chemical Technology and Biotechnology, 95(12):3071-3078. DOI:, 【indexed】

37. Tianwen Wang, Chen Liang, Mengyuan Zheng, Lu Liu, Yafei An, Hongju Xu, Sa Xiao and Lei Nie*, 2020, Ribosome hibernation as a stress response of bacteria, Protein and Peptide Letters, 27(11):1082-1091. DOI:, 【indexed】

Year 2019

36. Tianwen Wang*, Chen Liang, Yan Sun, Wanru Gao, Xinqi Luo, Qian Gao, Rui Li, Shuang Fu, Hongju Xu, Ting He and Hongyu Yuan, 2019, Strategical isolation of efficient chicken feather-degrading bacterial strains from tea plantation soil sample, International Microbiology, 22(2): 227-237. DOI:

Year 2018

35. Chen Liang, Ziwei Liu, Chaoping Liu, Yimeng Li, Hongyu Yuan and Tianwen Wang*, 2018, Cook your samples: the application of microwave irradiation in speeding up biological processes, Molecular Biotechnology, 60(3): 236-244. DOI:

34. Tianwen Wang, Xin Qin, Chen Liang and Hongyu Yuan*, 2018, Engineering substrate channeling in biosystems for improved efficiency, The Journal of Chemical Technology and Biotechnology, 93(12): 3364-3373. DOI:

Year 2016

33. Xufan Zhang, Fabiao Hu, Xingyuan Ma*, Tianwen Wang, Ping Wang and Xiaoli Wang, 2016, Design, construction, characterization and preliminary activity research of universal influenza virus vaccine (Flu@uV) delivered by Hepatitis B virus core protein (HBc-VLP), China Biotechnology, 36(2): 7-15. (中文论文)DOI:

32. Na Zhang, Hua Guo, Wenyun Zheng, Tianwen Wang and Xingyuan Ma*, 2016, Design and screening of a chimeric survivin-specific nanobody and its anticancer activities in vitro, Anticancer Drugs, 27(9): 839-47. DOI:

31. Shuke Wu, Yi Zhou, Tianwen Wang, Heng Phon Too, Daniel I.C. Wang and Zhi Li*, 2016, Highly regio- and enantioselective multiple oxy- and amino- functionalizations of alkenes by modular cascade biocatalysis, Nature Communications, 711917. DOI:

30. Di Liu, Na Zhang, Wenyun Zheng, Hua Guo, Xiaoli Wang, Tianwen Wang, Ping Wang* and Xingyuan Ma*, 2016, A novel method for efficient preparation of mucosal adjuvant Escherichia coli heat-labile enterotoxin mutant (LTm) by artificially assisted self-assembly in vitro, Applied Biochemistry and Biotechnology, 179(1): 33-45. DOI:

29. Di Liu, Huo Guo, Wenyun Zheng, Na Zhang, Tianwen Wang, Ping Wang and Xingyuan Ma*, 2016, Discovery of the cell-penetrating function of A2 domain derived from LTA subunit of Escherichia coli heat-labile enterotoxin, Applied Microbiology Biotechnology, 100(11): 5079-88. DOI:

28. Shixiu Cui#, Tianwen Wang#, Hong Hu, Liangwei Liu, Andong Song and Hongge Chen*, 2016, Investigating the expression of F10 and G11 xylanases in Aspergillus niger A09 with qPCR, Canadian Journal of Microbiology, 62(9): 744-52. DOI:

Year 2015

27. Tianwen Wang, Fei Ma, Xingyuan Ma and Ping Wang*, 2015, Spatially programmed assembling of oxidoreductases with single-stranded DNA for cofactor-requiring reactions, Applied Microbiology and Biotechnology, 99(8): 3469-77. DOI:

Year 2005-2014

26. Fei Ma#, Tianwen Wang#, Xingyuan Ma* and Ping Wang*, 2014, Identification and characterization of protein encoded by orf382 as L-threonine dehydrogenase, Journal of Microbiology and Biotechnology, 24(6): 748-55. DOI:

25. Nanjing Lin, Wenyun Zheng, Linfeng Li, Hui Liu, Tianwen Wang, Ping Wang and Xingyuan Ma*, 2014, A novel system enhancing the endosomal escapes of peptides promotes Bak BH3 peptide inducing apoptosis in lung cancer A549 cells, Targeted Oncology, 9(2): 163-70. DOI:

24. Chuanzhi Zhang, Junli Zhang, Zhen Kang*, Guocheng Du, Xiaobin Yu, Tianwen Wang and Jian Chen*, 2013, Enhanced production of L-phenylalanine in Corynebacterium glutamicum due to the introduction of Escherichia coli wild-type gene aroH, Journal of Industrial Microbiology and Biotechnology, 40(6): 643-51. DOI:

23. Jing Wang, Haiyan Zhou, Jianghua Li, Tianwen Wang, Long Liu*, Guocheng Du and Jian Chen, 2013, Influence of feeding L-tyrosine during induction phase on production of L-phenylalanine in fed-batch cultivation by recombinant Escherichia coli, Industrial Microbiology, 43(1): 24-29. (中文论文)DOI:Unavailable

22. Lei Shi, Lili Tang, Xingyuan Ma*, Tianwen Wang and Ping Wang, 2013, Efficient preparation of an anti-tumor protein TmSm by reversible phase transition of ELPs and self-cleaving function of intein, China Biotechnol., 33(10): 89-95.(中文论文) DOI:

21. Yun Hu, Tianwen Wang*, Guocheng Du and Jian Chen, 2013, Decreased acetic acid synthesis and enhanced L-phenylalanine production by E.coli WSH-Z06 (pAP-B03) using three stage glucose feeding strategy, Industrial Microbiology, 43(1): 6-10. (中文论文)DOI: Unavailable

20. Xiaofan Qiu, Tianwen Wang, Xiaomin Zhong, Guocheng Du* and Jian Chen*, 2012, Screening and characterization of an aerobic nitrifying-denitrifying bacterium from activated sludge, Biotechnology and Bioprocess Engineering, 17(2): 353-360. DOI:

19. Tianwen Wang, Aitao Li, Xingyuan Ma*, Guocheng Du and Jian Chen, 2012, A simple and universal method to express protein in unfused form, Protein and Peptide Letters, 19(9): 930-3. DOI:

18. Tianwen Wang, Xingyuan Ma*, Guocheng Du and Jian Chen, 2012, Overview of regulatory strategies and molecular elements in metabolic engineering of bacteria, Molecular Biotechnology, 52(3): 300-8. DOI:

17. Tianwen Wang, Xingyuan Ma*, Hu Zhu, Aitao Li, Guocheng Du and Jian Chen, 2012, Available methods for assembling expression cassettes for synthetic biology, Applied Microbiology and Biotechnology, 93(5): 1853-63. DOI:

16. Yuxin Xu, Wenyun Zheng, Tianwen Wang, Ping Wang, Ling Zhu and Xingyuan Ma*, 2012, Genetic protein TmSm(T34A) enhances sensitivity of chemotherapy to breast cancer cell lines as a synergistic drug to doxorubicin, Biomedicine & Pharmacotherapy, 66(5): 368-72. DOI:

15. Haiyan Zhou, Xianyan Liao, Long Liu, Tianwen Wang*, Guocheng Du* and Jian Chen, 2011, Enhanced L-phenylalanine production by recombinant Escherichia coli BR-42 (pAP-B03) resistant to bacteriophage BP-1 via a two-stage feeding approach, Journal of Industrial Microbiology and Biotechnology, 38(9): 1219-27. DOI:

14. Haiyan Zhou, Long Liu, Tianwen Wang*, Guocheng Du and Jian Chen, 2011, Recent advances in L-phenylalanine production by microbial fermentation, Industrial Microbiology, 41(3): 90-98. (中文论文)DOI:Unavailable

13. Haiyan Zhou, Xianyan Liao, Tianwen Wang, Guocheng Du* and Jian Chen*, 2010, Enhanced l-phenylalanine biosynthesis by co-expression of pheA(fbr) and aroF(wt), Bioresources Technology, 101(11): 4151-6. DOI:

12. Yun Hu, Tianwen Wang*, Xianyan Liao, Guocheng Du*, Jian Chen and Jigai Xu, 2010, Anti-oxidative stress and beyond: multiple functions of the protein glutathionylation, Protein and Peptide Letters, 17(10): 1234-44. DOI:

11. Tianwen Wang*, Aidong Qiu, Fanguo Meng and Haimeng Zhou, 2009, Changing the metal binding specificity of superoxide dismutase from Thermus thermophilus HB-27 by a single mutation, Molecular Biotechnology, 42(2): 146-53. DOI:

10. Hu Zhu, Tianwen Wang, Shujing Sun, Yaling Shen* and Dongzhi Wei*, 2006, Chromosomal integration of the Vitreoscilla hemoglobin gene and its physiological actions in Tremella fuciformis, Applied Microbiology and Biotechnology, 72(4): 770-6. DOI:

9. Hu Zhu, Ruojun Pan, Tianwen Wang, Yaling Shen* and Dongzhi Wei*, 2006, Functional solubilization of aggregation-prone TRAIL protein facilitated by coexpressing with protein isoaspartate methyltranferase, Applied Microbiology and Biotechnology, 72(5): 1033-8. DOI:

8. Tianwen Wang, Hu Zhu, Xingyuan Ma, Ting Zhang, Yushu Ma and Dongzhi Wei*, 2006, Mutant library construction in directed molecular evolution: casting a wider net, Molecular Biotechnology, 34(1): 55-68. DOI:

7. Tianwen Wang, Hu Zhu, Xingyuan Ma, Yushu Ma and Dongzhi Wei*, 2006, Structure-based stabilization of an enzyme: the case of penicillin acylase from Alcaligenes faecalis, Protein and Peptide Letters, 13(2): 177-83. DOI:

6. Tianwen Wang, Hu Zhu, Xingyuan Ma, Zhuoya Fei, Yushu Ma and Dongzhi Wei*, 2006, Enhancing enzymatic activity of penicillin G acylase by coexpressing pcm gene, Applied Microbiology Biotechnology, 72(5): 953-8. DOI:

5. Xingyuan Ma, Wenyun Zheng, Dongzhi Wei*, Yushu Ma, Tianwen Wang, Jinzhi Wang, Qinghai Liu and Shengli Yang, 2006, High-level expression, purification and pro-apoptosis activity of HIV- TAT-survivin (T34A) mutant to cancer cells in vitro, Journal of Biotechnology, 123(3): 367-78. DOI:

4. Xingyuan Ma, Wenyun Zheng, Dongzhi Wei*, Yushu Ma, Tianwen Wang, Jinzhi Wang, Qinghai Liu and Shengli Yang, 2006, Construction, expression, and purification of HIV-TAT-survivin (T34A) mutant: a pro-apoptosis protein in Escherichia coli, Protein Expression and Purification, 47(1): 36-44. DOI:

3. Xingyuan Ma, Wenyun Zheng, Tianwen Wang, Dongzhi Wei* and Yushu Ma, 2006, Optimization and high-level expression of a functional GST-tagged rHLT-B in Escherichia coli and GM1 binding ability of purified rHLT-B, Journal of Microbiology, 44(3): 293-300. DOI:English, Unavailable

2. Xingyuan Ma, Wenyun Zheng* and Tianwen Wang, 2006, Leukocyte function-associated antigen-1: structure, function and application prospects, Protein and Peptide Letters, 13(4): 397-400. DOI:

1. Wenyun Zheng, Xingyuan Ma, Dongzhi Wei*, Tianwen Wang, Yushu Ma and Shengli Yang, 2005, Molecular cloning and bioinformatics analysis of a novel spliced variant of survivin from human breast cancer cells, DNA Sequences, 16(5): 321-8. DOI:


  1. . Z.Li, T.Wang, J.Zhang,Preparation of Enantiopure Vicinal Diols and Alpha-Hydroxyketones from Racemic and Meso-Epoxides by Tandem Biocatalysis via Enantioselective Hydrolysis and Oxidations, International Patent Application No. PCT/SG2014/000299.
  2. . 授权发明专利:一种可降解废弃羽毛的菌株、筛选方法及其应用,中国专利授权号: ZL 201810663398.5,发明人: 王天文,梁辰,高婉茹,高倩,罗欣琪;
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  5. . 授权发明专利:大肠杆菌热敏毒素B亚单位的真核表达方法,中国专利授权号:ZL 200510027957.6,发明人:魏东芝, 马兴元, 郑文云, 王天文, 罗 晨, 马昱澍;
  6. . 授权发明专利:一种用于原核分泌、融合表达大肠杆菌热敏毒素B亚单位的载体, 中国专利授权号:ZL200510028084.0,发明人:魏东芝, 马兴元,王天文, 郑文云;
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