Theobaldtwang:Publications&patents
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Updated 2024/07/16, # equal contributor, * corresponding author
Journal articles
Year 2024
62. Qingtao Liu, Han Wang, Wenqing Zhang,Fan Cheng, Senhe Qian, Chuang Li, Yu Chen, Sibao Zhu, Tianwen Wang#, Shufang Tian#, 2024, A high salt-resistant urethanase degrades ethyl carbamate in soy sauce, Journal of Agricultural and Food Chemistry, DOI: 10.1021/acs.jafc.4c06162
61. 刘庆涛,朱司宝,王天文,李闯,钱森和,张温清,程凡,田淑芳,降解氨基甲酸乙酯的酯酶挖掘及酶学性质表征,食品科学,2024.8.23,网络首发
Year 2023
60. Sisi Wen, Kun Wang, Yujia Zhang, Jier Li, Xinyu Li, Yijia Qi, Tianwen Wang, Weichun Zhao, 2023, Preparation of monoclonal antibody and development of test strips enabling on-field detection of Botrytis cinerea infection on herbal medicinal plant Fritillaria thunbergii Miq, Journal of Plant Diseases and Protection, 130(5):1027-1040. DOI:10.1007/s41348-023-00753-5
59. Lei Nie, Pengbo Chang, Oseweuba Valentine Okoro, Musa Ayran, Oguzhan Gunduz, Kehui Hu, Tianwen Wang, Amin Shavandi, 2023, Synthesis, physicochemical characteristics, cytocompatibility, and antibacterial properties of iron-doped biphasic calcium phosphate nanoparticles with incorporation of silver. Biomedical Physics & Engineering Express, 9:065016. DOI:10.1088/2057-1976/acfcbe
58. Wei Zhang, Kun Liu, Fang Kong, Tao Ye, Tianwen Wang, 2023, Multiple functions of compatible solute ectoine and strategies for constructing overproducers for biobased production, Molecular Biotechnology, DOI:10.1007/s12033-023-00827-7
57. Wei Zhang, Tianwen Wang, 2023, Bioinformatics-aided protein sequence analysis and engineering, Current Protein and Peptide Science, 24(6):477-487. DOI:10.2174/1389203724666230509124300
56. Wei Zhang, Tianwen Wang, 2023, Understanding protein functions in the biological context, Protein and Peptide Letters, 30(6):449-458. DOI:10.2174/0929866530666230507212638
55. Ziyang Feng, Xinqi Cheng, Tianwen Wang, Yongchao Han, Haihong Chen, Xinyu Zhang, Jie Sun, Wei Zhang*, Feng Liu*, 2023, Investigation of GhFAT genes related to seed oil content and fatty acid composition in Gossypium hirsutum L. Phyton-International Journal of Experimental Botany, 92(5):1633-1647. DOI:10.32604/phyton.2023.027542
Year 2022
54. Ningning Yang,Siyuan Wang,Peng Ding,Shaolan Sun, Qianqian Wei, Hafez Jafari, Ling Wang, Yanting Han, Oseweuba Valentine Okorod, Tianwen Wang, Guicai Li, Amin Shavandi, Lei Nie, 2022, Magnesium-doped biphasic calcium phosphate nanoparticles with incorporation of silver: synthesis, cytotoxic and antibacterial properties, Materials Letters, 322:132478. DOI: 10.1016/j.matlet.2022.132478
53. Changping Deng, Fabiao Hu, Zhangting Zhao, Yiwen Zhou, Yuping Liu, Tong Zhang, Shihui Li, Wenyun Zheng, Wenliang Zhang, Tianwen Wang*, Xingyuan Ma, 2022, The establishment of quantitatively regulating expression cassette with sgRNA targeting BIRC5 to elucidate the synergistic pathway of Survivin with p-glycoprotein in cancer multi-drug resistance, Frontiers in Cell and Developmental Biology, section Molecular and Cellular Oncology, 9:797005. DOI:10.3389/fcell.2021.797005
Year 2021
52. Tianwen Wang*, Chen Liang, Sa Xiao, Li Li, Hongju Xu, Yafei An, Mengyuan Zheng and Lu Liu, 2021, A thermostable aluminum-tolerant protease produced by feather-degrading Bacillus thuringiensis isolated from tea plantation, Protein and Peptide Letters, 28(5):563-572. DOI:10.2174/0929866527666201103153309
51. Zixiao Liu#, Yanting Han#, Yongjie Zhou, Tianwen Wang, Shuaibin Lian*, Hongyu Yuan*, 2021, Transcriptomic analysis of tea plant (Camellia sinensis) revealed the co-expression network of 4111 paralogous genes and biosynthesis of quality-related key metabolites under multiple stresses, Genomics, 113(1):908-918. DOI:10.1016/j.ygeno.2020.10.023
50. Lei Nie, Ruijiao Zhang, Linfang Zhang, Mengyuan Ma, Congcong Li, Yi Zhang, Yafei An, Hongju Xu, Sa Xiao, Tianwen Wang*, 2021, Mutations in the regulatory regions result in increased streptomycin resistance and keratinase synthesis in Bacillus thuringiensis, Archives of Microbiology, 203(9):5387-5396. DOI:10.1007/s00203-021-02525-x
Year 2020
49. Qiuju Zhou#, Tianwen Wang#, Can Wang, Zheng Wang, Yanan Wang, Pei Li, Ruihua Cai, Meng Sun, Hongyu Yuan, Lei Nie*, 2020, Synthesis and characterization of silver nanoparticles-doped hydroxyapatite/alginate microparticles with promising histocompatibility and antibacterial properties, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 585:124081. DOI:10.1016/j.colsurfa.2019.124081
48. Tianwen Wang, Chen Liang, Yafei An, Sa Xiao, Hongju Xu, Mengyuan Zheng, Lu Liu, Gaozhan Wang, Lei Nie*, 2020, Engineering the translational machinery for biotechnology applications, Molecular Biotechnology, 62(4):219-227. DOI:10.1007/s12033-020-00246-y
47. Tianwen Wang, Chen Liang, Hongju Xu, Yafei An, Sa Xiao, Mengyuan Zheng, Lu Liu, Lei Nie*, 2020, Incorporation of nonstandard amino acids into proteins: principles and applications, World Journal of Microbiology and Biotechnology, 36(4):60. DOIht:10.1007/s11274-020-02837-y
46. Tianwen Wang, Hui Li, Chen Liang, Shiwei Sun, Ao Liu and Hu Zhu*, 2020, The high-efficient production of phelligridin LA by Inonotus baumii with an integrated fermentation-separation process, Bioprocess and Biosystems Engineering, 43(7):1141-1151. DOI:10.1007/s00449-020-02310-y
45. Tianwen Wang, Ningning Yang, Chen Liang, Hongju Xu, Yafei An, Sa Xiao, Mengyuan Zheng, Lu Liu, Gaozhan Wang, Lei Nie*, 2020, Detecting protein-protein interaction based on protein fragment complementation assay, Current Protein and Peptide Science, 21(6):598-610. DOI:10.2174/1389203721666200213102829
44. Tianwen Wang*, Chen Liang, Yajing Hou, Mengyuan Zheng, Hongju Xu, Yafei An, Sa Xiao, Lu Liu, Shuaibin Lian, 2020, Small design from big alignment: engineering protein with multiple sequence alignment as the starting point, Biotechnology Letters, 42(8):1305-1315. DOI:10.1007/s10529-020-02914-0
43. Shuaibin Lian, Zixiao Liu, Yongjie Zhou, Jiantao Guo, Ke Gong, Tianwen Wang*, 2020, The differential expression patterns and co-expression networks of paralogs as an indicator of the TNM stages of lung adenocarcinoma and squamous cell carcinoma, Genomics, 112(6):4115-4124. DOI:10.1016/j.ygeno.2020.07.019
42. Tianwen Wang, Hui Li, Chen Liang, Shiwei Sun, Ao Liu and Hu Zhu*, 2020, Purification and characterization of a novel antioxidant Phelligridin LA produced by Inonotus baumii, Journal of Chemical Technology and Biotechnology, 95(9):283-294. DOI:10.1002/JCTB.6430
41. Tianwen Wang, Fang Zhang, Kehui Hu, Rui Zhao, Yi Sun, Constantinus Politis, Shoufeng Yang, Lei Nie*, 2020, Polyvinyl alcohol/sodium alginate hydrogels incorporated with silver nanoclusters via green tea extract for antibacterial applications, Designed Monomers and Polymers, 23(1):118-133. DOI:10.1080/15685551.2020.1804183
40. Lei Nie, Mengjuan Hou, Tianwen Wang, Meng Sun, Ruixia Hou, 2020, Nanostructured selenium‑doped biphasic calcium phosphate with in situ incorporation of silver for antibacterial applications, Scientific Reports, 10:13738. DOI:10.1038/s41598-020-70776-7
39. Tianwen Wang, Shiwei Sun, Chen Liang, Hui Li, Ao Liu and Hu Zhu*, 2020, Effective isolation of antioxidant Phelligridin LA from the fermentation broth of Inonotus baumii by microporous resin, Bioprocess and Biosystems Engineering, 43(11):2095–2106. DOI:10.1007/s00449-020-02398-2
38. Tianwen Wang, Chen Liang, Wenxiu Xing, Wanyu Wu, Yajing Hou, Linfang Zhang, Sa Xiao, Hongju Xu, Yafei An, Mengyuan Zheng, Lu Liu, Lei Nie*, 2020, Transcriptional factor engineering in microbes for industrial biotechnology, Journal of Chemical Technology and Biotechnology, 95(12):3071-3078. DOI:10.1002/JCTB.6512
37. Tianwen Wang, Chen Liang, Mengyuan Zheng, Lu Liu, Yafei An, Hongju Xu, Sa Xiao, Lei Nie*, 2020, Ribosome hibernation as a stress response of bacteria, Protein and Peptide Letters, 27(11):1082-1091. DOI:10.2174/0929866527666200610142118
Year 2019
36. Tianwen Wang*, Chen Liang, Yan Sun, Wanru Gao, Xinqi Luo, Qian Gao, Rui Li, Shuang Fu, Hongju Xu, Ting He, Hongyu Yuan, 2019, Strategical isolation of efficient chicken feather-degrading bacterial strains from tea plantation soil sample, International Microbiology, 22(2):227-237. DOI:10.1007/s10123-018-00042-4
Year 2018
35. Chen Liang, Ziwei Liu, Chaoping Liu, Yimeng Li, Hongyu Yuan, Tianwen Wang*, 2018, Cook your samples: the application of microwave irradiation in speeding up biological processes, Molecular Biotechnology, 60(3):236-244. DOI:10.1007/s12033-018-0061-z
34. Tianwen Wang, Xin Qin, Chen Liang, Hongyu Yuan*, 2018, Engineering substrate channeling in biosystems for improved efficiency, The Journal of Chemical Technology and Biotechnology, 93(12):3364-3373. DOI:10.1002/jctb.5731
Year 2016
33. Xufan Zhang, Fabiao Hu, Xingyuan Ma*, Tianwen Wang, Ping Wang, Xiaoli Wang, 2016, Design, construction, characterization and preliminary activity research of universal influenza virus vaccine (Flu@uV) delivered by Hepatitis B virus core protein (HBc-VLP), China Biotechnology, 36(2):7-15. DOI:10.13523/j.cb.20160202 (In Chinese)
32. Na Zhang, Hua Guo, Wenyun Zheng, Tianwen Wang, Xingyuan Ma*, 2016, Design and screening of a chimeric survivin-specific nanobody and its anticancer activities in vitro, Anticancer Drugs, 27(9):839-847. DOI:10.1097/cad.0000000000000394
31. Shuke Wu, Yi Zhou, Tianwen Wang, Heng Phon Too, Daniel I.C. Wang, Zhi Li*, 2016, Highly regio- and enantioselective multiple oxy- and amino- functionalizations of alkenes by modular cascade biocatalysis, Nature Communications, 711917. DOI:10.1038/ncomms11917
30. Di Liu, Na Zhang, Wenyun Zheng, Hua Guo, Xiaoli Wang, Tianwen Wang, Ping Wang*, Xingyuan Ma*, 2016, A novel method for efficient preparation of mucosal adjuvant Escherichia coli heat-labile enterotoxin mutant (LTm) by artificially assisted self-assembly in vitro, Applied Biochemistry and Biotechnology, 179(1):33-45. DOI:10.1007/s12010-015-1977-4
29. Di Liu, Huo Guo, Wenyun Zheng, Na Zhang, Tianwen Wang, Ping Wang, Xingyuan Ma*, 2016, Discovery of the cell-penetrating function of A2 domain derived from LTA subunit of Escherichia coli heat-labile enterotoxin, Applied Microbiology Biotechnology, 100(11):5079-5088. DOI:10.1007/s00253-016-7423-x
28. Shixiu Cui#, Tianwen Wang#, Hong Hu, Liangwei Liu, Andong Song, Hongge Chen*, 2016, Investigating the expression of F10 and G11 xylanases in Aspergillus niger A09 with qPCR, Canadian Journal of Microbiology, 62(9):744-752. DOI:10.1139/cjm-2015-0394
Year 2015
27. Tianwen Wang, Fei Ma, Xingyuan Ma, Ping Wang*, 2015, Spatially programmed assembling of oxidoreductases with single-stranded DNA for cofactor-requiring reactions, Applied Microbiology and Biotechnology, 99(8):3469-3477. DOI:10.1007/s00253-014-6172-y
Year 2005-2014
26. Fei Ma#, Tianwen Wang#, Xingyuan Ma*, Wang*, 2014, Identification and characterization of protein encoded by orf382 as L-threonine dehydrogenase, Journal of Microbiology and Biotechnology, 24(6):748-755. DOI:10.4014/jmb.1312.12030
25. Nanjing Lin, Wenyun Zheng, Linfeng Li, Hui Liu, Tianwen Wang, Ping Wang, Xingyuan Ma*, 2014, A novel system enhancing the endosomal escapes of peptides promotes Bak BH3 peptide inducing apoptosis in lung cancer A549 cells, Targeted Oncology, 9(2):163-170. DOI:10.1007/s11523-013-0282-9
24. Chuanzhi Zhang, Junli Zhang, Zhen Kang*, Guocheng Du, Xiaobin Yu, Tianwen Wang and Jian Chen*, 2013, Enhanced production of L-phenylalanine in Corynebacterium glutamicum due to the introduction of Escherichia coli wild-type gene aroH, Journal of Industrial Microbiology and Biotechnology, 40(6):643-651. DOI:10.1007/s10295-013-1262-x
23. Jing Wang, Haiyan Zhou, Jianghua Li, Tianwen Wang, Long Liu*, Guocheng Du and Jian Chen, 2013, Influence of feeding L-tyrosine during induction phase on production of L-phenylalanine in fed-batch cultivation by recombinant Escherichia coli, Industrial Microbiology, 43(1):24-29.(In Chinese)
22. Lei Shi, Lili Tang, Xingyuan Ma*, Tianwen Wang, Ping Wang, 2013, Efficient preparation of an anti-tumor protein TmSm by reversible phase transition of ELPs and self-cleaving function of intein, China Biotechnol., 33(10):89-95. DOI:10.1007/s10295-013-1262-x (In Chinese)
21. Yun Hu, Tianwen Wang*, Guocheng Du, Jian Chen, 2013, Decreased acetic acid synthesis and enhanced L-phenylalanine production by E.coli WSH-Z06 (pAP-B03) using three stage glucose feeding strategy, Industrial Microbiology, 43(1):6-10. (In Chinese)
20. Xiaofan Qiu, Tianwen Wang, Xiaomin Zhong, Guocheng Du*, Jian Chen*, 2012, Screening and characterization of an aerobic nitrifying-denitrifying bacterium from activated sludge, Biotechnology and Bioprocess Engineering, 17(2):353-360. DOI:10.1007/s12257-011-0467-y
19. Tianwen Wang, Aitao Li, Xingyuan Ma*, Guocheng Du, Jian Chen, 2012, A simple and universal method to express protein in unfused form, Protein and Peptide Letters, 19(9):930-933. DOI:10.2174/092986612802084519
18. Tianwen Wang, Xingyuan Ma*, Guocheng Du, Jian Chen, 2012, Overview of regulatory strategies and molecular elements in metabolic engineering of bacteria, Molecular Biotechnology, 52(3):300-308. DOI:10.1007/s12033-012-9514-y
17. Tianwen Wang, Xingyuan Ma*, Hu Zhu, Aitao Li, Guocheng Du, Jian Chen, 2012, Available methods for assembling expression cassettes for synthetic biology, Applied Microbiology and Biotechnology, 93(5):1853-1863. DOI:10.1007/s00253-012-3920-8
16. Yuxin Xu, Wenyun Zheng, Tianwen Wang, Ping Wang, Ling Zhu, Xingyuan Ma*, 2012, Genetic protein TmSm(T34A) enhances sensitivity of chemotherapy to breast cancer cell lines as a synergistic drug to doxorubicin, Biomedicine & Pharmacotherapy, 66(5):368-372. DOI:10.1016/j.biopha.2011.12.004
15. Haiyan Zhou, Xianyan Liao, Long Liu, Tianwen Wang*, Guocheng Du*, Jian Chen, 2011, Enhanced L-phenylalanine production by recombinant Escherichia coli BR-42 (pAP-B03) resistant to bacteriophage BP-1 via a two-stage feeding approach, Journal of Industrial Microbiology and Biotechnology, 38(9):1219-1227. DOI:10.1007/s10295-010-0900-9
14. Haiyan Zhou, Long Liu, Tianwen Wang*, Guocheng Du, Jian Chen, 2011, Recent advances in L-phenylalanine production by microbial fermentation, Industrial Microbiology, 41(3):90-98. (In Chinese)
13. Haiyan Zhou, Xianyan Liao, Tianwen Wang, Guocheng Du*, Jian Chen*, 2010, Enhanced l-phenylalanine biosynthesis by co-expression of pheA(fbr) and aroF(wt), Bioresources Technology, 101(11):4151-4156. DOI:10.1016/j.biortech.2010.01.043
12. Yun Hu, Tianwen Wang*, Xianyan Liao, Guocheng Du*, Jian Chen, Jigai Xu, 2010, Anti-oxidative stress and beyond: multiple functions of the protein glutathionylation, Protein and Peptide Letters, 17(10):1234-1244. DOI:10.2174/092986610792231573
11. Tianwen Wang*, Aidong Qiu, Fanguo Meng, Haimeng Zhou, 2009, Changing the metal binding specificity of superoxide dismutase from Thermus thermophilus HB-27 by a single mutation, Molecular Biotechnology, 42(2):146-153. DOI:10.1007/s12033-009-9149-9
10. Hu Zhu, Tianwen Wang, Shujing Sun, Yaling Shen*, Dongzhi Wei*, 2006, Chromosomal integration of the Vitreoscilla hemoglobin gene and its physiological actions in Tremella fuciformis, Applied Microbiology and Biotechnology, 72(4):770-776. DOI:10.1007/s00253-006-0322-9
9. Hu Zhu, Ruojun Pan, Tianwen Wang, Yaling Shen*, Dongzhi Wei*, 2006, Functional solubilization of aggregation-prone TRAIL protein facilitated by coexpressing with protein isoaspartate methyltranferase, Applied Microbiology and Biotechnology, 72(5):1033-1038. DOI:10.1007/s00253-006-0383-9
8. Tianwen Wang, Hu Zhu, Xingyuan Ma, Ting Zhang, Yushu Ma, Dongzhi Wei*, 2006, Mutant library construction in directed molecular evolution: casting a wider net, Molecular Biotechnology, 34(1):55-68. DOI:10.1385/mb:34:1:55
7. Tianwen Wang, Hu Zhu, Xingyuan Ma, Yushu Ma, Dongzhi Wei*, 2006, Structure-based stabilization of an enzyme: the case of penicillin acylase from Alcaligenes faecalis, Protein and Peptide Letters, 13(2):177-183. DOI:10.2174/092986606775101571
6. Tianwen Wang, Hu Zhu, Xingyuan Ma, Zhuoya Fei, Yushu Ma, Dongzhi Wei*, 2006, Enhancing enzymatic activity of penicillin G acylase by coexpressing pcm gene, Applied Microbiology Biotechnology, 72(5):953-958. DOI:10.1007/s00253-006-0349-y
5. Xingyuan Ma, Wenyun Zheng, Dongzhi Wei*, Yushu Ma, Tianwen Wang, Jinzhi Wang, Qinghai Liu, Shengli Yang, 2006, High-level expression, purification and pro-apoptosis activity of HIV- TAT-survivin (T34A) mutant to cancer cells in vitro, Journal of Biotechnology, 123(3):367-378. DOI:10.1016/j.jbiotec.2005.11.018
4. Xingyuan Ma, Wenyun Zheng, Dongzhi Wei*, Yushu Ma, Tianwen Wang, Jinzhi Wang, Qinghai Liu, Shengli Yang, 2006, Construction, expression, and purification of HIV-TAT-survivin (T34A) mutant: a pro-apoptosis protein in Escherichia coli, Protein Expression and Purification, 47(1):36-44. DOI:10.1016/j.pep.2005.09.012
3. Xingyuan Ma, Wenyun Zheng, Tianwen Wang, Dongzhi Wei*, Yushu Ma, 2006, Optimization and high-level expression of a functional GST-tagged rHLT-B in Escherichia coli and GM1 binding ability of purified rHLT-B, Journal of Microbiology, 44(3):293-300.
2. Xingyuan Ma, Wenyun Zheng* and Tianwen Wang, 2006, Leukocyte function-associated antigen-1: structure, function and application prospects, Protein and Peptide Letters, 13(4):397-400. DOI:10.2174/092986606775974429
1. Wenyun Zheng, Xingyuan Ma, Dongzhi Wei*, Tianwen Wang, Yushu Ma and Shengli Yang, 2005, Molecular cloning and bioinformatics analysis of a novel spliced variant of survivin from human breast cancer cells, DNA Sequences, 16(5):321-328. DOI:10.1080/10425170500226490
Patents
- .发明专利:一种用于多个基因片段组装的试剂及其组装方法;申请号:202410574087.7;发明人:王天文,方天志,邵雅萍,薛正莲;
- .发明专利:一种优化依克多因生物合成途径中基因剂量的方法;申请号:202410631564.9;发明人:王天文,方天志,李丹丹,刘庆涛,邵雅萍,黄祖帆,薛正莲;
- .发明专利:一种耐酸酯酶在降解氨基甲酸乙酯中的应用及表达载体和工程菌;申请号:202410181366.7;发明人:刘庆涛,杨浩,王天文,钱森和,朱司宝,汪涵,同阿成;
- .发明专利:一种可降解氨基甲酸乙酯的酯酶、表达载体、工程菌及其应用;申请号:202410181367.1发明人:刘庆涛,朱司宝,钱森和,王天文,汪涵,杨浩,同阿成;
- .发明专利:一种耐高盐酰胺酶、基因、载体、重组菌及应用;申请号:202410286207.3;发明人:刘庆涛,汪涵,田淑芳,李丹丹,王天文,钱森和,陶董墨农,周阿成,朱司宝,李元昊
- .Z.Li, T.Wang, J.Zhang,Preparation of Enantiopure Vicinal Diols and Alpha-Hydroxyketones from Racemic and Meso-Epoxides by Tandem Biocatalysis via Enantioselective Hydrolysis and Oxidations, International Patent Application No. PCT/SG2014/000299.
- .授权发明专利:一种可降解废弃羽毛的菌株、筛选方法及其应用,中国专利授权号: ZL 201810663398.5,发明人: 王天文,梁辰,高婉茹,高倩,罗欣琪;
- .发明专利: 一种提高角蛋白酶活力的方法,公开(公告)号:CN 109797145A, 发明人: 王天文,梁辰,安亚菲,肖飒,徐红菊;
- .发明专利: 一种提高大肠杆菌生长性能的方法,公开(公告)号:CN 108060174A,发明人:王天文,靳会巧,刘紫薇,李一萌,罗欣琪,袁红雨;
- .授权发明专利:大肠杆菌热敏毒素B亚单位的真核表达方法,中国专利授权号:ZL 200510027957.6,发明人:魏东芝, 马兴元, 郑文云, 王天文, 罗 晨, 马昱澍;
- .授权发明专利:一种用于原核分泌、融合表达大肠杆菌热敏毒素B亚单位的载体, 中国专利授权号:ZL200510028084.0,发明人:魏东芝, 马兴元,王天文, 郑文云;
- .授权发明专利:一种ssDNA-蛋白质酶法交联方法,公开(公告)号:CN103361321; 发明人:王天文,马兴元,马飞,王平;(授权公告日:2015.2.28,ZL2013 1 0261812.7, 第1589468号)
- .发明专利:一种微生物发酵生产L-苯丙氨酸的方法,公开(公告)号: CN102399835;发明人:陈坚,张传志,堵国成,康振,周景文,王天文;
- .发明专利:一种产碱性蛋白酶基因工程菌及其应用,公开(公告)号: CN102174453;发明人: 陈坚,张传志,堵国成,王天文;
- .发明专利:一株好氧除磷菌——恶臭假单胞菌WSH1002及其应用,公开(公告)号:CN102181375;发明人:郑展望,陈坚,堵国成,仲小敏,王天文,徐甦,刘斌,丁青松;
- .发明专利:一株好氧反硝化菌及其筛选方法和应用,公开(公告)号:CN102115719;发明人:陈坚,堵国成,王天文,邱晓帆,仲小敏;
- .发明专利:一种生物法生产l-苯丙氨酸的方法, 公开(公告)号: CN101984066;发明人:陈坚,堵国成,王天文,胡云;
- .发明专利:一种抗噬菌体L-苯丙氨酸生产菌及选育方法和其应用,公开(公告)号:CN102010847;发明人:陈坚,堵国成,周海岩,廖鲜艳,薛晓驰,王天文;
- .发明专利:重组耐高温超氧化物岐化酶的高密度发酵与纯化工艺,公开(公告)号:CN101275144;发明人:孟凡国,夏勇,王天文,胡卫江,周海梦。