Crystalline spherulites growing from an amorphous drug
The Taylor Lab is part of the Department of Industrial and Physical Pharmacy at Purdue University.
Our lab is interested in exploring the fundamental science underlying the preformulation, formulation and manufacturing of drugs and drug/nutraceutical/food products. We collaborate with other academic groups as well as scientists working in industry. Our research has been funded by the National Science Foundation, the National Institutes of Health, the United States Department of Agriculture, and a variety of pharmaceutical and food companies. Our goal is to attain an improved molecular level understanding of complex organic materials and formulations such as pharmaceutical dosage forms through the use of high resolution analytical techniques. Of particular interest are water-solid interactions and disordered systems, especially amorphous solid dispersions. Current emphasis is on the phase behavior of amorphous systems during storage and on dissolution. Vibrational spectroscopic methods, in conjunction with other techniques such as X-ray diffraction and calorimetry, are used to provide information about the physical state of the solid e.g. crystalline or amorphous, the response of the material to changes in temperature and relative humidity and the nature of drug-drug, drug-excipient and drug-water interactions.
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