SynBERC:Parts
From OpenWetWare
Jump to navigationJump to search
This is a draft list of research topics that the SynBERC Parts Thrust is considering for support.
Please contribute & edit with impunity.
We need to get the set of topics correct and then organize ourselves (and anybody else who wants) around getting the work done.
Sign up for the parts mailing list!
Goals
1. Parts collection, registry
2. Parts characterization
3. Parts engineering
- a. New function
- b. Tune strength, timing
- c. Orthogonal, composable function
- d. Develop general methods for part redesign
Part Families
Transcriptional
- repressors, DNA binding proteins
- terminators
- promoters
Translational
- RBS
- Riboregulators
- mRNA procesing
Degradation
- degrons
Secretion
- Targeting sequences
Sensing/actuating
- protein binding
- small molecule ligand binding
- light sensing
- switches
Assembly
- Protein-protein interactions (orthogonal set)
Phosphorylation logic control
- Kinases
- Phosphatases
- Docking motifs
- phosphorecognition
Biosynthetic enzymes
Transporters
Cell adhesion
Chassis parts
- Vectors
- YAC components
- Transposon components
Projected Parts Application to Testbeds
Tumor Killing Bacteria[1]
- Gene expression devices
- Transcriptional parts
- Translational parts (riboregulators)
- Post-Translational device
- Degradation
- Phosphorylation logic
- Sensing/actuating/signaling devices
- Sensing/actuating parts
- Assembly – assembly based logic
- Riboregulators
- Phosphorylation logic
- Cell adhesion, targeting
- Chassis parts
Microbial drug factory
- Gene expression devices
- Transcriptional parts
- Translational parts (riboregulators)
- Post-Translational device
- Degradation
- Phosphorylation logic
- Biosynthetic devices
- Engineered metabolic enzymes (malic acid to malic semi-aldehyde)
- Sensing/actuating/signaling devices
- Sensing/actuating parts
- Assembly – assembly based logic
- Riboregulators
- Phosphorylation logic
- Transporters
- Chassis parts
