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OpenSourceMalaria:Triazolopyrazine (TP) Series: Difference between revisions
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OpenSourceMalaria:Triazolopyrazine (TP) Series (view source)
Revision as of 05:03, 21 November 2016
, 21 November 2016→Desirable Compounds Not Yet Synthesised
Matthew Todd (talk | contribs) |
Matthew Todd (talk | contribs) |
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[[Image:Internal Alkene.png|thumb|right|80px|Internal Alkene]] | [[Image:Internal Alkene.png|thumb|right|80px|Internal Alkene]] | ||
[[Image:The 6.png|thumb|right|80px|The 6]] | [[Image:The 6.png|thumb|right|80px|The 6]] | ||
[[Image:The 8.png|thumb|right|80px|The 8]] | |||
[[Image:The Burns.png|thumb|right|80px|The Burns]] | [[Image:The Burns.png|thumb|right|80px|The Burns]] | ||
[[Image:The Nemesis.png|thumb|right|80px|The Nemesis]] | [[Image:The Nemesis.png|thumb|right|80px|The Nemesis]] | ||
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SGPCUHISMIPDDU-TWGQIWQCSA-N | SGPCUHISMIPDDU-TWGQIWQCSA-N | ||
The '''6''' (probe of tolerance to ring substitution): [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues/401 Synthesis proposal], [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues/428 Start of synthesis], [http://malaria.ourexperiment.org/synthesis_of__the_6 ELN] | The '''6''' (probe of tolerance to ring substitution): [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues/401 Synthesis proposal], [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues/428 Start of synthesis], [http://malaria.ourexperiment.org/synthesis_of__the_6 ELN]. [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues/461 Second phase Haverford attempt] with [http://malaria.ourexperiment.org/haverford_college_s second ELN] | ||
FC(F)OC(C=C1)=CC=C1C2=NN=C3C=NC(C)=C(OCC(O)C4=CC=CC=C4)N32 | FC(F)OC(C=C1)=CC=C1C2=NN=C3C=NC(C)=C(OCC(O)C4=CC=CC=C4)N32 | ||
InChI=1S/C21H18F2N4O3/c1-13-20(29-12-17(28)14-5-3-2-4-6-14)27-18(11-24-13)25-26-19(27)15-7-9-16(10-8-15)30-21(22)23/h2-11,17,21,28H,12H2,1H3 | InChI=1S/C21H18F2N4O3/c1-13-20(29-12-17(28)14-5-3-2-4-6-14)27-18(11-24-13)25-26-19(27)15-7-9-16(10-8-15)30-21(22)23/h2-11,17,21,28H,12H2,1H3 | ||
ZYFKQWHTACKGJR-UHFFFAOYSA-N | ZYFKQWHTACKGJR-UHFFFAOYSA-N | ||
The '''8''' (also a probe of tolerance to ring substitution): [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues/402 Haverford synthesis plan], [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues/429 Start of Haverford synthesis], [http://malaria.ourexperiment.org/superlabthe8 ELN], [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues/456 Summary and closure of first attempt], [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues/461 cross-link to new attempt at 6- and 8-] | |||
FC(F)OC(C=C1)=CC=C1C2=NN=C3C(C)=NC=C(OCC(O)C4=CC=CC=C4)N32 | |||
InChI=1S/C21H18F2N4O3/c1-13-19-25-26-20(15-7-9-16(10-8-15)30-21(22)23)27(19)18(11-24-13)29-12-17(28)14-5-3-2-4-6-14/h2-11,17,21,28H,12H2,1H3 | |||
ASWYMQOLUDKKDJ-UHFFFAOYSA-N | |||
The '''Burns''' (amide isostere): [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues/404 Proposed synthesis from Haverford College], [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues/422 Start of synthesis], Discussion of results of intermediate steps [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues/438 here] and [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues/450 here], [http://malaria.ourexperiment.org/the_burns ELN] including [http://malaria.ourexperiment.org/the_burns/14906/Synthesis_of__Nbenzyl16chloropyrazin2yl222trifluoroethan1amine_EVKCN_14.html summary of outcomes of first attempt]. [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues/459 Start of second attempt] with new [http://malaria.ourexperiment.org/hc_superlab_ ELN]. | The '''Burns''' (amide isostere): [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues/404 Proposed synthesis from Haverford College], [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues/422 Start of synthesis], Discussion of results of intermediate steps [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues/438 here] and [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues/450 here], [http://malaria.ourexperiment.org/the_burns ELN] including [http://malaria.ourexperiment.org/the_burns/14906/Synthesis_of__Nbenzyl16chloropyrazin2yl222trifluoroethan1amine_EVKCN_14.html summary of outcomes of first attempt]. [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues/459 Start of second attempt] with new [http://malaria.ourexperiment.org/hc_superlab_ ELN]. | ||
