CHEM-ENG590E Wiki Textbook:Microcontact Printing: Difference between revisions

CHEM-ENG590E Wiki Textbook:Microcontact Printing (view source)

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 Microcontact printing has also been employed in biosensor fabrication. Salomon et al. demonstrated precise printing of an antibody IgG and an antifouling compound BSA on a nanocantilever structure array. Cantilevers are a common structure used in biosensors, and an array of nanocantilevers allows for high selectivity and precise detection. The IgG was printed on the nanocantilevers, while the BSA was printed underneath and around the nanocantilevers.
-Fabricated nanocantilever array.png
+Fabricated nanocantilever array.pngSchematics of the NEMS functionalization process using a PDMS stamp; two approaches can be used: A. Surface functionalization by microcontact printing followed by blocking the remaining surfaces with a batch process. B. Surface functionalization and passivation both carried out by microcontact printing. (1) Inking the stamp with the desired molecules (IgG1). (2) Washing and drying the stamp. (3) Cleaning outside the stamp grooves, i.e. removing the molecules from the stamp base, by carrying multiple prints. (3B) Inking the stamp with the anti-fouling molecules (BSA). (4) Printing after aligning the stamp and the chip. (4A) Incubating the chip with the anti-fouling molecule (BSA). (5) Result of the NEMS biofunctionalization process.
 ==Challenges of Microcontact Printing==