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Crisanti:Andrew M Hammond: Difference between revisions
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==Research interests== | ==Research interests== | ||
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I am a PhD student in Crisanti | I am a PhD student in [[Crisanti:Crisanti Lab | Crisanti Lab]] at [http://www.imperial.ac.uk/ Imperial College], working towards the development of a synthetic gene drive strategy for population suppression in malaria mosquitoes. As a lab, we are investigating the use of HEGs, TALENs and CRISPR as a homing endonuclease to invade and subsequently supress mosquito populations – as initially theorised by the principal investigator, Professor Austin Burt. | ||
My work is focused upon CRISPR, validating it as a tool for genome engineering in mosquitoes and testing the potential to use it in a gene drive. Previous research has predicted that an endonuclease-based gene drive targeting a female fertility gene would efficiently suppress populations if the mutations to this gene result in a recessive sterile phenotype. | My work is focused upon CRISPR, validating it as a tool for genome engineering in mosquitoes and testing the potential to use it in a gene drive. Previous research has predicted that an endonuclease-based gene drive targeting a female fertility gene would efficiently suppress populations if the mutations to this gene result in a recessive sterile phenotype. | ||
