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We are exploring the scope, scale, and causes of protein misfolding and its effects on organism fitness, with a strong focus on newly synthesized proteins. Using the yeast <i>Saccharomyces cerevisiae</i> as a model system, our research combines evolutionary genomics, which reveals broad patterns of fitness imprinted in DNA, with system- and molecular-level misfolding studies designed to illuminate the conserved biochemistry underlying these patterns. | We are exploring the scope, scale, and causes of protein misfolding and its effects on organism fitness, with a strong focus on newly synthesized proteins. Using the yeast <i>Saccharomyces cerevisiae</i> as a model system, our research combines evolutionary genomics, which reveals broad patterns of fitness imprinted in DNA, with system- and molecular-level misfolding studies designed to illuminate the conserved biochemistry underlying these patterns. | ||
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Check out our [http://www.cell.com/content/article/abstract?uid=PIIS0092867408007058 paper in Cell] and a writeup in the [http://www.news.harvard.edu/gazette/2008/07.24/00-drummond.html Harvard Gazette] | Check out our [http://www.cell.com/content/article/abstract?uid=PIIS0092867408007058 paper in Cell] and a writeup in the [http://www.news.harvard.edu/gazette/2008/07.24/00-drummond.html Harvard Gazette]. | ||
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