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Griffin:Antibody Basics: Difference between revisions
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====Kappa/Lambda Ratios==== | ====Kappa/Lambda Ratios==== | ||
Murine immunoglobulins consist distinct heavy chains and either of two light chains (κ or λ) | |||
In all antibodies there are 2 light chain types, kappa and lambda. | In all antibodies there are 2 light chain types, kappa and lambda. | ||
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*HUMAN 2:1 | *HUMAN 2:1 | ||
*BOVINE 1:20 | *BOVINE 1:20 | ||
Each (~200-220 amino acid) light chain = two tandem disulfide bridged immunoglobulin domains | |||
*1 constant (CL) (kappa or lambda) domain | |||
*1 variable (VL) (antigen Binding) domain | |||
===F(ab')2 fragment=== | ===F(ab')2 fragment=== | ||
