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Summary
- It is useful to have independent control of cellular physical quantities.
- Outline of a system for controlling the mean and variance of protein expression population distributions.
References
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Error fetching PMID 14581474 - Ozbudak EM, Thattai M, Kurtser I, Grossman AD, and van Oudenaarden A. Regulation of noise in the expression of a single gene. Nat Genet. 2002 May;31(1):69-73. DOI:10.1038/ng869 | PubMed ID:11967532 | HubMed [Ozbodak]
- Error fetching PMID 10850721 [Becskei]
- Error fetching PMID 15544806 [Swain]
- Error fetching PMID 11097920 [Smolke]
- Error fetching PMID 9933514 [Carrier]
- Error fetching PMID 14581474 [Lamontagne]
All Medline abstracts: PubMed | HubMed
Additional
- for more on the ideas of independence and reachability, look into control theory. Richard Murray at Caltech is working on a text, which is online: Feedback Systems - An Introduction for Scientists and Engineers. Also, the idea of observability is interesting to think about, in terms of what cellular processes we can study and understand.
- Also, the slides are best viewed with the soundtrack of MC Hammer's U Can't Touch This, a thoughtful piece on man's ability to use tools (symbolically the hammer) to manipulate and understand nature.
- please leave comments or feedback here: -Kelsic
- "sweetness is my weakness" - MC Hammer / Tsbayer
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