Smolke:Kelsic:11-1-06 talk

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  • It is useful to have independent control of cellular physical quantities.
  • Outline of a system for controlling the mean and variance of protein expression population distributions.



  1. Ozbudak EM, Thattai M, Kurtser I, Grossman AD, and van Oudenaarden A. Regulation of noise in the expression of a single gene. Nat Genet. 2002 May;31(1):69-73. DOI:10.1038/ng869 | PubMed ID:11967532 | HubMed [Ozbodak]
  2. Becskei A and Serrano L. Engineering stability in gene networks by autoregulation. Nature. 2000 Jun 1;405(6786):590-3. DOI:10.1038/35014651 | PubMed ID:10850721 | HubMed [Becskei]
  3. Swain PS. Efficient attenuation of stochasticity in gene expression through post-transcriptional control. J Mol Biol. 2004 Dec 3;344(4):965-76. DOI:10.1016/j.jmb.2004.09.073 | PubMed ID:15544806 | HubMed [Swain]
  4. Smolke CD, Carrier TA, and Keasling JD. Coordinated, differential expression of two genes through directed mRNA cleavage and stabilization by secondary structures. Appl Environ Microbiol. 2000 Dec;66(12):5399-405. DOI:10.1128/aem.66.12.5399-5405.2000 | PubMed ID:11097920 | HubMed [Smolke]
  5. Carrier TA and Keasling JD. Library of synthetic 5' secondary structures to manipulate mRNA stability in Escherichia coli. Biotechnol Prog. 1999 Jan-Feb;15(1):58-64. DOI:10.1021/bp9801143 | PubMed ID:9933514 | HubMed [Carrier]
  6. Lamontagne B and Elela SA. Evaluation of the RNA determinants for bacterial and yeast RNase III binding and cleavage. J Biol Chem. 2004 Jan 16;279(3):2231-41. DOI:10.1074/jbc.M309324200 | PubMed ID:14581474 | HubMed [Lamontagne]
All Medline abstracts: PubMed | HubMed



  • please leave comments or feedback here: -Kelsic
  • "sweetness is my weakness" - MC Hammer / Tsbayer