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M13K07 Phage Genome Renovation Ideas

Proposed Changes

  • Put genes I, IV, XI under a stronger promoter
    • Create more pores for phage to be extruded
    • Too many pores could be harmful to host cell

Summary of Changes

Gene Function Renovation Ideas
I Assembly (inner membrane) Stronger promoter
II Replication of + ssDNA
III Tail (interacts with F pilus)
IV Assembly (outer membrane) Stronger promoter
V Binds ssDNA
VI Tail (buried under III)
VII Head (buried under IX)
IX Head (exposed)
X DNA Replication
XI Assembly (inner membrane) Stronger Promoter