Renhao Li Lab:Publications

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98. Liang Q, Parker ET, Dean G, Karpen MS, Wu J, Wang X, Di Paola J, Maier CL, Meeks SL, Lollar P, Sidonio RF, Li R

Nanobody activator improves sensitivity of the VWF activity assay to multimer size
J. Thromb. Haemost.Online ahead of print PMID 38704122

97. Arce NA, Markham-Lee Z, Liang Q, Najmudin S, Legan ER, Dean G, Su AJ, Wilson MS, Sidonio RF, Lollar P, Emsley J, Li R

Conformational activation and inhibition of von Willebrand factor by targeting its autoinhibitory module
Blood 143: 1992-2004, 2024 PMID 38290109
with a Commentary in Blood 143:1887-1888


95. Li R

Platelet size matters
Blood 143: 298-300, 2024 PMID 38270943

94. Saccuzzo EG, Mebrat MD, Scelsi HF, Kim M, Ma MT, Su X, Hill SE, Rheaume E, Li R, Torres MP, Gumbart JC, Van Horn WD, Lieberman RL

Competition between inside-out unfolding and pathogenic aggregation in an amyloid-forming β-propeller
Nat. Commun. 15: 155, 2024 PMID 38168102


93. Duan Y, Szlam F, Hu Y, Chen W, Li R, Ke Y, Sniecinski R, Salaita K

Detection of cellular traction forces via the force-triggered Cas12a-mediated catalytic cleavage of a fluorogenic reporter strand
Nat. Biomed. Eng. 7: 1404-1418, 2023 PMID 37957275

92. Von Beck T, Navarette K, Arce NA, Gao M, Dale GA, Davis-Gardner ME, Floyd K, Hernandez LM, Mullick N, Vanderheiden A, Skountzou I, Kuchipudi S, Saravanan R, Li R, Skolnick J, Suthar MS, Jacob J

A wild boar cathelicidin peptide derivative inhibits severe acute respiratory syndrome coronavirus-2 and its drifted variants
Sci. Rep. 13: 14650, 2023 PMID 37670110

91. Ma R, Rashid SA, Velusamy A, Deal BR, Chen W, Petrich B, Li R, Salaita K

Molecular mechanocytometry using tension-activated cell tagging (TaCT)
Nat. Methods 20: 1666-1671, 2023 PMID 37798479

90. Li R

Another layer of complexity in ectodomain shedding of platelet GPIbα
J. Thromb. Haemost. 21: 2051-2053, 2023 PMID 37468175

89. Wang Y, Li R

Specific O-glycans in the mechanosensory domain of glycoprotein Ibα are important for its stability and function
Haematologica 108(9): 2526-2530, 2023 PMID 36779596

86. Beck S, Oftering P, Li R, Hemmen K, Nagy M, Wang Y, Zarpellon A, Schuhmann MK, Stoll G, Ruggeri ZM, Heinze KG, Heemskerk JWM, Ruf W, Stegner D, Nieswandt B.

Platelet glycoprotein V spatiotemporally controls fibrin formation
Nat. Cardiovasc. Res. 2:368-382, 2023PMID 37206993

88. Legan ER, Liu Y, Arce NA, Parker ET, Lollar P, Zhang XF, Li R

Type 2B von Willebrand disease mutations differentially perturb autoinhibition of the A1 domain
Blood 141:1221-1232, 2023 PMID 36580664
with a Commentary in Blood 141:1102-1103


87. Huang W, Li R, Zhang J, Cheng Y, Ramakrishnan DP, Silverstein RL

A CD36 transmembrane domain peptide interrupts CD36 interactions with membrane partners on macrophages and inhibits atherogenic functions
Transl. Res. 254:68-76, 2023 PMID 36377115


85. Li R

Recent advances on GPIb-IX-V complex (editorial)
Platelets 33:809-810, 2022 PMID 35543611

84. Arce NA, Liu Y, Chen W, Zhang XF, Li R

Autoinhibitory module underlies species difference in shear activation of von Willebrand factor
J. Thromb. Haemost. 20:2686-2696, 2022 PMID 36031939

83. Chen W, Wilson MS, Wang Y, Bergmeier W, Lanza F, Li R

Fast clearance of platelets in a commonly used mouse model for GPIbα is impeded by an anti-GPIbβ antibody derivative
J. Thromb. Haemost. 20:1451-1463, 2022 PMID 35305057

82. Ito J, Baldwin WH, Cox C, Healey J, Parker E, Legan ER, Li R, Gill S, Batsuli G

Removal of single-site N-linked glycans on factor VIII alters binding of domain-specific monoclonal antibodies
J. Thromb. Haemost. 20:574-588, 2022 PMID 34863021

81. Voos KM, Cao W, Arce NA, Legan ER, Wang Y, Shajahan A, Azadi P, Lollar P, Zhang XF, Li R

Desialylation of O-glycans activates Von Willebrand factor by destabilizing its autoinhibitory module
J. Thromb. Haemost. 20:196-207, 2022 PMID 34529349
Made journal cover



80. Blanchard A, Combs DJ, Brockman JM, Kellner AV, Glazier R, Su H, Bender RL, Bazrafshan A, Chen W, Quach ME, Li R, Mattheyses AL, Salaita K

Turn-key mapping of cell receptor force orientation and magnitude using a commercial structured illumination microscope
Nat. Commun. 12: 4693, 2021 PMID 34344862

79. Hu Y, Ma VPY, Ma R, Chen W, Duan Y, Glazier R, Petrich B, Li R, Salaita K

DNA-based microparticle tension sensors (µTS) for measuring cell mechanics in non-planar geometries and for high-throughput quantification
Angew. Chem. Int. Ed. Engl. 60: 18044-18050, 2021PMID 33979471

78. Arce NA, Cao W, Brown AK, Legan ER, Wilson MS, Xu E-R, Berndt MC, Emsley J, Zhang XF*, Li R*

Activation of Von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module
Nat. Commun. 12: 2360, 2021 PMID 33883551

77. Quach ME, Chen W, Wang Y, Deckmyn H, Lanza F, Nieswandt B, Li R

Differential regulation of the platelet GPIb-IX complex by anti-GPIbb antibodies
J. Thromb. Haemost. 19: 2044-2055, 2021 PMID 33915031

73. Wang Y, Chen W, Zhang W, Lee-Sundlov MM, Casari C, Berndt MC, Lanza F, Bergmeier W, Hoffmeister KM, Zhang XF, Li R

Desialylation of O-glycans on glycoprotein Ibα drives receptor signaling and platelet clearance
Haematologica 106: 220-229, 2021 PMID 31974202


76. Quach ME, Li R

Structure-function of platelet glycoprotein Ib-IX
J. Thromb. Haemost. 18: 3131-3134, 2020 PMID 32735697

75. Brockman JM, Su H, Blanchard AT, Duan Y, Meyer T, Quach ME, Glazier R, Bazrafshan A, Bender RL, Kellner AV, Ogasawara H, Ma R, Schueder F, Petrich BG, Jungmann R, Li R, Mattheyses AL, Ke Y, Salaita K

Live-cell super-resolved PAINT imaging of pN cellular traction forces
Nat. Methods 17: 1018-1024, 2020 PMID 32929270

74. Fiore M, De Thore C, Randrianaivo-Ranjatoelina H, Baas MJ, Jacquemont ML, Darcel F, Dreyfus M, Lavenu-Bombled C, Li R, Gachet C, Dupuis A, Lanza F

High prevalence of the natural Asn89Asp mutation in the GP1BB gene associated with Bernard-Soulier syndrome in French patients from the genetic isolate of Reunion island
Br. J. Haematol. 189: e67-e71, 2020 PMID 31997307

70. Tao Yª, Gan Cª, Zhang X, Liu L, Zakas PM, Doering CB, Mo X*, Li R*

Unaccompanied mechanosensory domain mediates low expression of glycoprotein Ibα: Implications for Bernard-Soulier syndrome
J. Thromb. Haemost. 18: 510-517, 2020 PMID 31749281

72. Legan ER, Li R

Gone with the vane
Arterioscler. Thromb. Vasc. Biol. 39: 1702-1704, 2019 PMID 31433699

71. Arce NA, Li R

The secret afterlife of platelets
Haematologica 104: 1699-1701, 2019 PMID 31473608

69. Legan ER, Li R

FAM-tastic phospho-regulation of von Willebrand factor activity
J. Thromb. Haemost. 17: 863-865, 2019. PMID 30985992

68. Proulle V, Strassel C, Perrault C, Baas M-J, Moog S, Mangin P, Nurden P, Nurden A, Adam F, Bryckaert M, Kauskot A, Li R, Lanza F

A novel missense mutation in a Leucine-rich repeat of GPIbα in a Bernard-Soulier variant reduces shear-dependent adherence on von Willebrand factor
Br. J. Haematol. 186: e184-e187, 2019 PMID 31257572

67. Chen W, Voos KM, Josephson CD, Li R

Short-acting anti-VWF aptamer improves the recovery, survival, and hemostatic functions of refrigerated platelets
Arterioscler. Thromb. Vasc. Biol. 39: 2028-2037, 2019. PMID 31315441
with a Commentary in Arterioscler. Thromb. Vasc. Biol. 39: 1893-1895


66. Quach ME, Syed AK, Li R

A uniform shear assay for human platelet and cell surface receptors via cone-plate viscometry
J. Vis. Exp. 148: e59704, 2019. PMID 31233025

65. Zhang XF*, Zhang W, Quach ME, Deng W, Li R*

Force-regulated refolding of the mechanosensory domain in the platelet glycoprotein Ib-IX complex
Biophys. J. 116: 1960-1969, 2019. PMID 31030883

64. Li C, Voos KM, Pathak M, Hall G, McCrae KR, Dreveny I, Li R, Emsley J

Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI
J. Thromb. Haemost. 17: 759-770, 2019. PMID 30801944

63. Qi Y, Chen W, Liang X, Xu K, Gu X, Wu F, Fan X, Ren S, Liu J, Zhang J, Li R, Liu J, Liang X

Novel antibodies against GPIbα inhibit pulmonary metastasis by affecting VWF-GPIbα interaction
J. Hematol. Oncol. 11: 117, 2018. PMID 30223883

62. Baaten CC, Swieringa F, Misztal T, Mastenbroek TG, Feijge MA, Bock PE, Donners MM, Collins PW, Li R, van der Meijden PE, Heemskerk JW

Platelet heterogeneity in activation-induced glycoprotein shedding: functional effects
Blood Adv. 2: 2320-2331, 2018. PMID 30232085

61. Deng W, Voos KM, Colucci JK, Legan ER, Ortlund EA, Lollar P, Li R

Delimiting the autoinhibitory module of von Willebrand factor
J. Thromb. Haemost. 16: 2097-2105, 2018. PMID 30053340

60. Wang B, Perez-Pathke A, Li R, Liang J

A general method for predicting amino acid residues experiencing hydrogen exchange
IEEE EMBS Int Conf Biomed Health Inform. 2018: 341-344. PMID 29780972

59. Deng W, Voos KM, Li R

A new redox switch regulating von Willebrand factor activity
J. Thromb. Haemost. 16: 1257-1258, 2018 PMID 29846041

58. Cook AA, Deng W, Ren J, Li R, Sondek J, Bergmeier W

Calcium-induced structural rearrangements release autoinhibition in the Rap-GEF, CalDAG-GEFI
J. Biol. Chem. 293: 8521-8529, 2018 PMID 29622678

57. Quach ME, Chen W, Li R

Mechanisms of platelet clearance and translation to improve platelet storage
Blood 131: 1512-1521, 2018 PMID 29475962

56. Li R

The Glycoprotein Ib-IX-V Complex
Platelets (4th edition) Eds. Michelson AD, Cattaneo M, Frelinger L, Newman PJ. Elsevier/Academic Press

54. Quach ME, Dragovich MA, Chen W, Syed AK, Cao W, Liang X, Deng W, De Meyer SF, Zhu G, Peng J, Ni H, Bennett CM, Hou M, Ware J, Deckmyn H, Zhang XF, Li R

Fc-independent immune thrombocytopenia via mechanomolecular signaling in platelets
Blood 131: 787-796, 2018 PMID 29203584
with a commentary in Blood 131: 713-714 Inside Blood Commentary


55. Chen W, Druzak SA, Wang Y, Josephson CD, Hoffmeister KM, Ware J, Li R

Refrigeration-induced binding of von Willebrand factor facilitates fast clearance of refrigerated platelets
Arterioscler. Thromb. Vasc. Biol. 37: 2271-2279, 2017 PMID 29097365

53. Li R

Twins actin' differently
Blood 130: 1688-1689, 2017 PMID 29025716

52. Deng W, Wang Y, Druzak SA, Healey JF, Syed AK, Lollar P, Li R

A discontinuous autoinhibitory module masks the A1 domain of von Willebrand factor
J. Thromb. Haemost. 15: 1867-1877, 2017 PMID 28692141

51. Lavenu-Bombled C, Guitton C, Dupuis A, Baas MJ, Desconclois C, Dreyfus M, Li R, Caron C, Gachet C, Fressinaud E, Lanza F

A novel platelet-type von Willebrand disease mutation (GP1BA p.Met255Ile) associated with type 2B "Malmö/New York" von Willebrand disease
Thromb. Haemost. 116: 1070-1078, 2016. PMID 27683759

50. W. Deng, Y. Xu, W. Chen, D. S. Paul, A. K. Syed, M. A. Dragovich, X. Liang, P. Zakas, M. C. Berndt, J. Di Paola, J. Ware, F. Lanza, C. B. Doering, W. Bergmeier, X. F. Zhang, R. Li

Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor
Nat. Commun. 7: 12863, 2016. PMID 27670775
Emory press release
CHOA Peds research news


49. G. Batsuli, W. Deng, J. F. Healey, E. T. Parker, W. H. Baldwin, C. Cox, B. Nguyen, J. Kahle, C. Koenigs, R. Li, P. Lollar, S. L. Meeks

High-affinity, non-inhibitory pathogenic C1 domain antibodies are present in patients with hemophilia A and inhibitors
Blood 128: 2055-2067, 2016 PMID 27381905
with a commentary in Blood 128: 2001-2002 Inside Blood Commentary

48. W. Chenª, X. Liangª, A. K. Syed, P. Jessup, W. R. Church, J. Ware, C. D. Josephson, R. Li

Inhibiting GPIbα shedding preserves post-transfusion recovery and hemostatic function of platelets after prolonged storage
Arterioscler. Thromb. Vasc. Biol. 36: 1821-1828, 2016. PMID 27417583
with an Editorial in ATVB 36: 1715-1716 ATVB online


47. Y. Taoª, X. Zhangª, X. Liang, J. Zang, X. Mo*, R. Li*

Structural basis for the specific inhibition of glycoprotein Ibα shedding by an inhibitory antibody
Sci. Rep. 6: 24789, 2016. PMID 27102061

46. R. Li, K. M. Hoffmeister, H. Falet

Glycans and the platelet life cycle
Platelets 27: 505-511, 2016. PMID 27135356

45. X. Liang, A. K. Syed, S. R. Russell, J. Ware, R. Li

Dimerization of glycoprotein Ibα is not sufficient to induce platelet clearance
J. Thromb. Haemost. 14: 381-386, 2016. PMID 26662889


44. S.L. Spitalnik, et al. State of the Science in Transfusion Medicine Working Groups (R. Li listed as a part of working groups)

2015 proceedings of the National Heart, Lung, and Blood Institute's State of the Science in Transfusion Medicine symposium.
Transfusion 55: 2282-2290, 2015. Pubmed

43. R. Li

Expanding the binding model of DITP
Blood 126: 2080-2081, 2015. Pubmed

42. J. Ciciliano, Y. Sakurai, D. R. Myers, M. E. Fay, B. Hechler, S. L. Meeks, R. Li, J. B. Dixon, L. A. Lyon, C. Gachet, W. A. Lam

Resolving the multifaceted mechanisms of the ferric chloride thrombosis model using an interdisciplinary microfluidic approach
Blood 126: 817-824, 2015. Pubmed

41. W. Deng, R. Li

Juxtamembrane contribution to transmembrane signaling
Biopolymers (Pept. Sci.) 104: 317-322, 2015. Pubmed

40. W. Zhangª, W. Dengª, L. Zhou, Y. Xu, W. Yang, X. Liang, Y. Wang, J. D. Kulman, X. F. Zhang*, R. Li*

Identification of a juxtamembrane mechano-sensitive domain in the platelet mechanosensor glycoprotein Ib-IX-V complex
Blood 125: 562-569, 2015. Pubmed or Blood online
with commentary in Blood 125: 423-424 Blood online


39. W. Deng, S. Cho, P.-C. Su, B. W. Berger, R. Li

Membrane-enabled dimerization of the intrinsically disordered cytoplasmic domain of ADAM10
Proc. Natl. Acad. Sci. (track II) 111: 15987-92, 2014. Pubmed

38. Y. Morioka, C. Casari, N. Wohner, S. Cho, S. Kurata, A. Kitano, O.D. Christophe, P.J. Lenting, R. Li, C.V. Denis, N. Prevost

Expression of a structurally constrained von Willebrand factor variant triggers acute thrombotic thrombocytopenic purpura in mice.
Blood 123: 3344-53, 2014. Pubmed

37. L. Zhou, W. Yang, R. Li

Analysis of inter-subunit contacts reveals the structural malleability of extracellular domains in platelet glycoprotein Ib-IX complex.
J. Thromb. Haemost. 12: 82-89, 2014. Pubmed

36. A. M. Sevy, J. F. Healey, W. Deng, P. C. Spiegel, S. L. Meeks*, R. Li*

Epitope mapping of inhibitory antibodies targeting the C2 domain of coagulation factor VIII by hydrogen-deuterium exchange mass spectrometry.
J. Thromb. Haemost. 11: 2128-2136, 2013 Pubmed
Made journal cover Gallery


35. X. Liang, S. R. Russell, S. Estelle, L. H. Jones, S. Cho, M. L. Kahn, M. C. Berndt, S. T. Bunting, J. Ware, R. Li

Specific inhibition of ectodomain shedding of glycoprotein Ibα by targeting its juxtamembrane shedding cleavage site.
J. Thromb. Haemost. 11: 2155-2162, 2013 Pubmed

34. W. Deng, S. Cho, R. Li

FERM domain of moesin desorbs the basic-rich cytoplasmic domain of L-selectin from the anionic membrane surface.
J. Mol. Biol. 425: 3549-3562, 2013 Pubmed

33. P. Mou, Z. Zeng, Q. Li, X. Liu, X. Xin, K. M. Wannemacher, C. Ruan, R. Li, L. F. Brass, L. Zhu

Identification of a calmodulin-binding domain in Sema4D that regulates its exodomain shedding in platelets.
Blood 121: 4221-30, 2013 Pubmed

32. W. Deng, J. A. Putkey, R. Li

Calmodulin adopts an extended conformation when interacting with L-selectin in membranes.
PLoS ONE 8: e62861, 2013 Pubmed or PLoS ONE online

31. R. Li*, J. Emsley

The organizing principle of platelet glycoprotein Ib-IX-V complex.
J. Thromb. Haemost. 11: 605-614, 2013 Pubmed

30. X. Mo, L. Liu, J. A. Lopez, R. Li

Transmembrane domains are critical to the interaction between platelet glycoprotein V and glycoprotein Ib-IX complex.
J. Thromb. Haemost. 10: 1875-1886, 2012. Pubmed
Made journal cover Gallery


29. R. Yan, X. Mo, A. M. Paredes, K. Dai, F. Lanza, M. A. Cruz, R. Li

Reconstitution of platelet glycoprotein Ib-IX complex in phospholipid bilayer nanodiscs.
Biochemistry 50: 10598-10606, 2011. Pubmed

28. P. A. McEwanª, W. Yangª, K. H. Carrª, X. Mo, X. Zheng, R. Li*, J. Emsley*

Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIbβ and a GPIbβ/GPIX chimera.
Blood 118: 5292-5301, 2011. Pubmed or Blood online
with commentary in Blood 118: 5065-5066 Blood online

27. W. Deng, S. Srinivasan, X. Zheng, J. A. Putkey, R. Li

Interaction of calmodulin with L-selectin at the membrane interface: implication on the regulation of L-selectin shedding.
J. Mol. Biol. 411: 220-233, 2011. Pubmed

26. S. Srinivasanª, W. Dengª, R. Li

L-selectin transmembrane and cytoplasmic domains are monomeric in membranes.
Biochim. Biophys. Acta 1808: 1709-1715, 2011. Pubmed

25. Z. Zhou, H.-C. Yeh, H. Jing, C. Wang, Z. Tao, H. Choi, K. Aboulfatova, R. Li, J.-F. Dong

Cysteine residues in CUB-1 domain are critical for ADAMTS13 secretion and stability.
Thromb. Haemost. 105: 21-30, 2011. Pubmed

Before 2010

24. X. Mo, N. X. Nguyen, F.-T. Mu, W. Yang, S.-Z. Luo, H. Fan, R. K. Andrews, M. C. Berndt, R. Li

Trans-membrane and trans-subunit regulation of ectodomain shedding of platelet glycoprotein Ibα.
J. Biol. Chem. 285: 32096-32104, 2010. Pubmed

23. R. Li

A hypothesis that explains the heterogeneity of drug-induced immune thrombocytopenia.
Blood 115: 914, 2010. Pubmed

22. X. Mo, N. X. Nguyen, P. A. McEwan, X. Zheng, J. A. López, J. Emsley, R. Li

Binding of platelet glycoprotein Ibβ through the convex surface of leucine-rich repeats domain of glycoprotein IX.
J. Thromb. Haemost. 7: 1533-1540, 2009. Pubmed

21. Z. Zhou, H. Jing, Z. Tao, H. Choi, K. Aboulfatova, J. Moake, R. Li, J.-F. Dong

Effects of naturally occurring mutations in CUB-1 domain on synthesis, stability, and activity of ADAMTS-13.
Thromb. Res. 124: 323-327, 2009. Pubmed

20. X. Mo, S.-Z. Luo, J. A. López, R. Li

Juxtamembrane basic residues in the glycoprotein Ibβ cytoplasmic domain are required for assembly and surface expression of glycoprotein Ib-IX complex.
FEBS Lett. 582: 3270-3274, 2008. Pubmed

19. S.-Z. Luo, R. Li

Specific heteromeric association of four transmembrane peptides derived from platelet glycoprotein Ib-IX complex.
J. Mol. Biol. 382: 448-457, 2008. Pubmed

18. X. Mo, S.-Z. Luo, A. D. Munday, W. Sun, M. C. Berndt, J. A. López, J.-F. Dong, R. Li

The membrane-proximal intermolecular disulfide bonds in glycoprotein Ib influence receptor binding to von Willebrand factor.
J. Thromb. Haemost. 6: 1789-1795, 2008. Pubmed

17. S.-Z. Luo, X. Mo, J. A. López, R. Li

Role of the transmembrane domain of glycoprotein IX in assembly of the glycoprotein Ib-IX complex.
J. Thromb. Haemost. 5: 2494-2502, 2007. Pubmed

16. S.-Z. Luoª, X. Moª, V. Afshar-Kharghan, S. Srinivasan, J. A. López, R. Li

Glycoprotein Ibα forms disulfide bonds with 2 glycoprotein Ibβ subunits in the resting platelet.
Blood 109: 603-609, 2007. Pubmed
(with commentary in Blood 109: 393-394)

15. X. Mo, N. Lu, A. Padilla, J. A. López, R. Li

The transmembrane domain of glycoprotein Ibβ is critical to efficient surface expression of glycoprotein Ib-IX complex in the plasma membrane.
J. Biol. Chem. 281: 23050-23059, 2006. Pubmed

14. Z. Tao, Y. Peng, L. Nolasco, S. Cal, C. Lopez-Otin, R. Li, J. F. Moake, J. A. López, J.-F. Dong

Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions.
Blood 106: 4139-4145, 2005. Pubmed

Postdoctoral Work

13. W. Li, D. G. Metcalf, R. Gorelik, R. Li, N. Mitra, V. Nanda, P. B. Law, J. D. Lear, W. F. DeGrado, J. S. Bennett

A push-pull mechanism for regulating integrin function.
Proc. Natl. Acad. Sci. 102: 1424-1429, 2005. Pubmed

12. R. Li, R. Gorelik, V. Nanda, P. B. Law, J. D. Lear, W. F. DeGrado, J. S. Bennett

Dimerization of the transmembrane domain of integrin αIIb subunit in cell membranes.
J. Biol. Chem. 279: 26666-26673, 2004. Pubmed

11. R. Li, J. S. Bennett, W. F. DeGrado

Structural basis for integrin αIIbβ3 clustering.
Biochem. Soc. Trans. 32: 412-415, 2004. Pubmed

10. R. Li, N. Mitra, H. Gratkowski, G. Vilaire, R. Litvinov, C. Nagasami, J. W. Weisel, J. D. Lear, W. F. DeGrado, J. S. Bennett

Activation of integrin αIIbβ3 by modulation of transmembrane helix associations.
Science 300: 795-798, 2003. Pubmed
(commentary in Science 300: 755-756)

9. R. Li, R. H. Hoess, J. S. Bennett, W. F. DeGrado

Use of a phage displayed protein scaffold for determining binding specificity to integrins.
Protein Eng. 16: 65-72, 2003. Pubmed

8. R. Li, C. R. Babu, K. Valentine, J. D. Lear, A. J. Wand, J. S. Bennett, W. F. DeGrado

Characterization of the monomeric form of the transmembrane and cytoplasmic domains of integrin β3 subunit by NMR spectroscopy.
Biochemistry 41: 15618-15624, 2002. Pubmed

5. R. Li, C. R. Babu, J. D. Lear, A. J. Wand, J. S. Bennett, W. F. DeGrado

Oligomerization of the integrin αIIbβ3: roles of the transmembrane and cytoplasmic domains.
Proc. Natl. Acad. Sci. 98: 12462-12467, 2001. Pubmed

Graduate Work

7. R. Li, J. L. Battiste, C. Woodward

Native-like interactions favored in the unfolded bovine pancreatic trypsin inhibitor have different roles in folding.
Biochemistry 41: 2246-2253, 2002. Pubmed

6. J. L. Battiste, R. Li, C. Woodward

A highly destabilizing mutation, G37A, of the bovine pancreatic trypsin inhibitor retains the average native conformation but greatly increases local flexibility.
Biochemistry 41: 2237-2245, 2002. Pubmed

4. K. Akasaka, H. Li, H. Yamada, R. Li, T. Thoresen, C. Woodward

Pressure response of protein backbone structure. Pressure-induced amide 15N-chemical shifts in BPTI.
Protein Sci. 8: 1946-1953, 1999. Pubmed

3. R. Li, C. Woodward

The hydrogen exchange core and protein folding.
Protein Sci. 8: 1571-1590, 1999. Pubmed

2. C. Woodward, R. Li

The slow-exchange core and protein folding.
Trends Biochem. Sci. 23: 379-381, 1998. Pubmed

1. J. Ng, R. Li, K. Morgan, J. Simon

Evolutionary conservation and predicted structure of the Drosophila extra sex combs repressor protein.
Mol. Cell. Biol. 17: 6663-6672, 1997. Pubmed

Once upon a time ...

1,2-Dichloroethane degradation pathway map
Biocatalysis/Biodegradation Database

(ª, co-first author; *, co-corresponding author)