Renhao Li Lab:Publications

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73. Legan ER, Li R

Gone with the vane
Arterioscler. Thromb. Vasc. Biol. 39: 1702-1704, 2019 Pubmed

72. Arce NA, Li R

The secret afterlife of platelets
Haematologica 104: 1699-1701, 2019 Pubmed

71. Tao Y, Gan C, Zhang X, Liu L, Zakas PM, Doering CB, Mo X, Li R

Unaccompanied mechanosensory domain mediates low expression of glycoprotein Iba and pathogenesis of Bernard-Soulier syndrome

70. Huang W, Li R, Cheng Y, Ramakrishnan DP, Silverstein RL

A CD36 transmembrane domain peptide interrupts plasma membrane protein-protein interactions and inhibits CD36 function

68. Proulle V, Strassel C, Perrault C, Baas M-J, Moog S, Mangin P, Nurden P, Nurden A, Adam F, Bryckaert M, Kauskot A, Li R, Lanza F

A novel missense mutation in a Leucine-rich repeat of GPIba in a Bernard-Soulier variant reduces shear-dependent adherence on von Willebrand factor
Br. J. Haematol. 186: e184-e187, 2019 Pubmed

67. Chen W, Voos KM, Josephson CD, Li R

Short-acting anti-VWF aptamer improves the recovery, survival, and hemostatic functions of refrigerated platelets
Arterioscler. Thromb. Vasc. Biol. 39: 2028-2037, 2019. Pubmed
with a Commentary in Arterioscler. Thromb. Vasc. Biol. 39: 1893-1895


66. Quach ME, Syed AK, Li R

A uniform shear assay for human platelet and cell surface receptors via cone-plate viscometry
J. Vis. Exp. 148: e59704, 2019. Pubmed

69. Legan ER, Li R

FAM-tastic phospho-regulation of von Willebrand factor activity
J. Thromb. Haemost. 17: 863-865, 2019. Pubmed

65. Zhang XF*, Zhang W, Quach ME, Deng W, Li R*

Force-regulated refolding of the mechanosensory domain in the platelet glycoprotein Ib-IX complex
Biophys. J. 116: 1960-1969, 2019. Pubmed

64. Li C, Voos KM, Pathak M, Hall G, McCrae KR, Dreveny I, Li R, Emsley J

Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI
J. Thromb. Haemost. 17: 759-770, 2019. Pubmed


63. Qi Y, Chen W, Liang X, Xu K, Gu X, Wu F, Fan X, Ren S, Liu J, Zhang J, Li R, Liu J, Liang X

Novel antibodies against GPIbα inhibit pulmonary metastasis by affecting VWF-GPIbα interaction
J. Hematol. Oncol. 11: 117, 2018. Pubmed

62. Baaten CC, Swieringa F, Misztal T, Mastenbroek TG, Feijge MA, Bock PE, Donners MM, Collins PW, Li R, van der Meijden PE, Heemskerk JW

Platelet heterogeneity in activation-induced glycoprotein shedding: functional effects
Blood Adv. 2: 2320-2331, 2018. Pubmed

61. Deng W, Voos KM, Colucci JK, Legan ER, Ortlund EA, Lollar P, Li R

Delimiting the autoinhibitory module of von Willebrand factor
J. Thromb. Haemost. 16: 2097-2105, 2018. Pubmed

60. Wang B, Perez-Pathke A, Li R, Liang J

A general method for predicting amino acid residues experiencing hydrogen exchange
IEEE EMBS Int Conf Biomed Health Inform. 2018: 341-344. Pubmed

59. Deng W, Voos KM, Li R

A new redox switch regulating von Willebrand factor activity
J. Thromb. Haemost. 16: 1257-1258, 2018 Pubmed

58. Cook AA, Deng W, Ren J, Li R, Sondek J, Bergmeier W

Calcium-induced structural rearrangements release autoinhibition in the Rap-GEF, CalDAG-GEFI
J. Biol. Chem. 293: 8521-8529, 2018 Pubmed

57. Quach ME, Chen W, Li R

Mechanisms of platelet clearance and translation to improve platelet storage
Blood 131: 1512-1521, 2018 Pubmed

56. Li R

The Glycoprotein Ib-IX-V Complex
Platelets (4th edition) Eds. Michelson AD, Cattaneo M, Frelinger L, Newman PJ. Elsevier/Academic Press

54. Quach ME, Dragovich MA, Chen W, Syed AK, Cao W, Liang X, Deng W, De Meyer SF, Zhu G, Peng J, Ni H, Bennett CM, Hou M, Ware J, Deckmyn H, Zhang XF, Li R

Fc-independent immune thrombocytopenia via mechanomolecular signaling in platelets
Blood 131: 787-796, 2018 Pubmed
with a commentary in Blood 131: 713-714 Inside Blood Commentary



55. Chen W, Druzak SA, Wang Y, Josephson CD, Hoffmeister KM, Ware J, Li R

Refrigeration-induced binding of von Willebrand factor facilitates fast clearance of refrigerated platelets
Arterioscler. Thromb. Vasc. Biol. 37: 2271-2279, 2017 Pubmed

53. Li R

Twins actin' differently
Blood 130: 1688-1689, 2017 Pubmed

52. Deng W, Wang Y, Druzak SA, Healey JF, Syed AK, Lollar P, Li R

A discontinuous autoinhibitory module masks the A1 domain of von Willebrand factor
J. Thromb. Haemost. 15: 1867-1877, 2017 Pubmed


51. Lavenu-Bombled C, Guitton C, Dupuis A, Baas MJ, Desconclois C, Dreyfus M, Li R, Caron C, Gachet C, Fressinaud E, Lanza F

A novel platelet-type von Willebrand disease mutation (GP1BA p.Met255Ile) associated with type 2B "Malmö/New York" von Willebrand disease
Thromb. Haemost. 116: 1070-1078, 2016. Pubmed

50. W. Deng, Y. Xu, W. Chen, D. S. Paul, A. K. Syed, M. A. Dragovich, X. Liang, P. Zakas, M. C. Berndt, J. Di Paola, J. Ware, F. Lanza, C. B. Doering, W. Bergmeier, X. F. Zhang, R. Li

Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor
Nat. Commun. 7: 12863, 2016. Pubmed
Emory press release
CHOA Peds research news


49. G. Batsuli, W. Deng, J. F. Healey, E. T. Parker, W. H. Baldwin, C. Cox, B. Nguyen, J. Kahle, C. Koenigs, R. Li, P. Lollar, S. L. Meeks

High-affinity, non-inhibitory pathogenic C1 domain antibodies are present in patients with hemophilia A and inhibitors
Blood 128: 2055-2067, 2016 Pubmed
with a commentary in Blood 128: 2001-2002 Inside Blood Commentary

48. W. Chenª, X. Liangª, A. K. Syed, P. Jessup, W. R. Church, J. Ware, C. D. Josephson, R. Li

Inhibiting GPIbα shedding preserves post-transfusion recovery and hemostatic function of platelets after prolonged storage
Arterioscler. Thromb. Vasc. Biol. 36: 1821-1828, 2016. Pubmed
with an Editorial in ATVB 36: 1715-1716 ATVB online


47. Y. Taoª, X. Zhangª, X. Liang, J. Zang, X. Mo*, R. Li*

Structural basis for the specific inhibition of glycoprotein Ibα shedding by an inhibitory antibody
Sci. Rep. 6: 24789, 2016. Pubmed

46. R. Li, K. M. Hoffmeister, H. Falet

Glycans and the platelet life cycle
Platelets 27: 505-511, 2016. Pubmed

45. X. Liang, A. K. Syed, S. R. Russell, J. Ware, R. Li

Dimerization of glycoprotein Ibα is not sufficient to induce platelet clearance
J. Thromb. Haemost. 14: 381-386, 2016. Pubmed


44. S.L. Spitalnik, et al. State of the Science in Transfusion Medicine Working Groups (R. Li listed as a part of working groups)

2015 proceedings of the National Heart, Lung, and Blood Institute's State of the Science in Transfusion Medicine symposium.
Transfusion 55: 2282-2290, 2015. Pubmed

43. R. Li

Expanding the binding model of DITP
Blood 126: 2080-2081, 2015. Pubmed

42. J. Ciciliano, Y. Sakurai, D. R. Myers, M. E. Fay, B. Hechler, S. L. Meeks, R. Li, J. B. Dixon, L. A. Lyon, C. Gachet, W. A. Lam

Resolving the multifaceted mechanisms of the ferric chloride thrombosis model using an interdisciplinary microfluidic approach
Blood 126: 817-824, 2015. Pubmed

41. W. Deng, R. Li

Juxtamembrane contribution to transmembrane signaling
Biopolymers (Pept. Sci.) 104: 317-322, 2015. Pubmed

40. W. Zhangª, W. Dengª, L. Zhou, Y. Xu, W. Yang, X. Liang, Y. Wang, J. D. Kulman, X. F. Zhang*, R. Li*

Identification of a juxtamembrane mechano-sensitive domain in the platelet mechanosensor glycoprotein Ib-IX-V complex
Blood 125: 562-569, 2015. Pubmed or Blood online
with commentary in Blood 125: 423-424 Blood online


39. W. Deng, S. Cho, P.-C. Su, B. W. Berger, R. Li

Membrane-enabled dimerization of the intrinsically disordered cytoplasmic domain of ADAM10
Proc. Natl. Acad. Sci. (track II) 111: 15987-92, 2014. Pubmed

38. Y. Morioka, C. Casari, N. Wohner, S. Cho, S. Kurata, A. Kitano, O.D. Christophe, P.J. Lenting, R. Li, C.V. Denis, N. Prevost

Expression of a structurally constrained von Willebrand factor variant triggers acute thrombotic thrombocytopenic purpura in mice.
Blood 123: 3344-53, 2014. Pubmed

37. L. Zhou, W. Yang, R. Li

Analysis of inter-subunit contacts reveals the structural malleability of extracellular domains in platelet glycoprotein Ib-IX complex.
J. Thromb. Haemost. 12: 82-89, 2014. Pubmed

36. A. M. Sevy, J. F. Healey, W. Deng, P. C. Spiegel, S. L. Meeks*, R. Li*

Epitope mapping of inhibitory antibodies targeting the C2 domain of coagulation factor VIII by hydrogen-deuterium exchange mass spectrometry.
J. Thromb. Haemost. 11: 2128-2136, 2013 Pubmed
Made journal cover Gallery


35. X. Liang, S. R. Russell, S. Estelle, L. H. Jones, S. Cho, M. L. Kahn, M. C. Berndt, S. T. Bunting, J. Ware, R. Li

Specific inhibition of ectodomain shedding of glycoprotein Ibα by targeting its juxtamembrane shedding cleavage site.
J. Thromb. Haemost. 11: 2155-2162, 2013 Pubmed

34. W. Deng, S. Cho, R. Li

FERM domain of moesin desorbs the basic-rich cytoplasmic domain of L-selectin from the anionic membrane surface.
J. Mol. Biol. 425: 3549-3562, 2013 Pubmed

33. P. Mou, Z. Zeng, Q. Li, X. Liu, X. Xin, K. M. Wannemacher, C. Ruan, R. Li, L. F. Brass, L. Zhu

Identification of a calmodulin-binding domain in Sema4D that regulates its exodomain shedding in platelets.
Blood 121: 4221-30, 2013 Pubmed

32. W. Deng, J. A. Putkey, R. Li

Calmodulin adopts an extended conformation when interacting with L-selectin in membranes.
PLoS ONE 8: e62861, 2013 Pubmed or PLoS ONE online

31. R. Li*, J. Emsley

The organizing principle of platelet glycoprotein Ib-IX-V complex.
J. Thromb. Haemost. 11: 605-614, 2013 Pubmed

30. X. Mo, L. Liu, J. A. Lopez, R. Li

Transmembrane domains are critical to the interaction between platelet glycoprotein V and glycoprotein Ib-IX complex.
J. Thromb. Haemost. 10: 1875-1886, 2012. Pubmed
Made journal cover Gallery


29. R. Yan, X. Mo, A. M. Paredes, K. Dai, F. Lanza, M. A. Cruz, R. Li

Reconstitution of platelet glycoprotein Ib-IX complex in phospholipid bilayer nanodiscs.
Biochemistry 50: 10598-10606, 2011. Pubmed

28. P. A. McEwanª, W. Yangª, K. H. Carrª, X. Mo, X. Zheng, R. Li*, J. Emsley*

Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIbβ and a GPIbβ/GPIX chimera.
Blood 118: 5292-5301, 2011. Pubmed or Blood online
with commentary in Blood 118: 5065-5066 Blood online

27. W. Deng, S. Srinivasan, X. Zheng, J. A. Putkey, R. Li

Interaction of calmodulin with L-selectin at the membrane interface: implication on the regulation of L-selectin shedding.
J. Mol. Biol. 411: 220-233, 2011. Pubmed

26. S. Srinivasanª, W. Dengª, R. Li

L-selectin transmembrane and cytoplasmic domains are monomeric in membranes.
Biochim. Biophys. Acta 1808: 1709-1715, 2011. Pubmed

25. Z. Zhou, H.-C. Yeh, H. Jing, C. Wang, Z. Tao, H. Choi, K. Aboulfatova, R. Li, J.-F. Dong

Cysteine residues in CUB-1 domain are critical for ADAMTS13 secretion and stability.
Thromb. Haemost. 105: 21-30, 2011. Pubmed

Before 2010

24. X. Mo, N. X. Nguyen, F.-T. Mu, W. Yang, S.-Z. Luo, H. Fan, R. K. Andrews, M. C. Berndt, R. Li

Trans-membrane and trans-subunit regulation of ectodomain shedding of platelet glycoprotein Ibα.
J. Biol. Chem. 285: 32096-32104, 2010. Pubmed

23. R. Li

A hypothesis that explains the heterogeneity of drug-induced immune thrombocytopenia.
Blood 115: 914, 2010. Pubmed

22. X. Mo, N. X. Nguyen, P. A. McEwan, X. Zheng, J. A. López, J. Emsley, R. Li

Binding of platelet glycoprotein Ibβ through the convex surface of leucine-rich repeats domain of glycoprotein IX.
J. Thromb. Haemost. 7: 1533-1540, 2009. Pubmed

21. Z. Zhou, H. Jing, Z. Tao, H. Choi, K. Aboulfatova, J. Moake, R. Li, J.-F. Dong

Effects of naturally occurring mutations in CUB-1 domain on synthesis, stability, and activity of ADAMTS-13.
Thromb. Res. 124: 323-327, 2009. Pubmed

20. X. Mo, S.-Z. Luo, J. A. López, R. Li

Juxtamembrane basic residues in the glycoprotein Ibβ cytoplasmic domain are required for assembly and surface expression of glycoprotein Ib-IX complex.
FEBS Lett. 582: 3270-3274, 2008. Pubmed

19. S.-Z. Luo, R. Li

Specific heteromeric association of four transmembrane peptides derived from platelet glycoprotein Ib-IX complex.
J. Mol. Biol. 382: 448-457, 2008. Pubmed

18. X. Mo, S.-Z. Luo, A. D. Munday, W. Sun, M. C. Berndt, J. A. López, J.-F. Dong, R. Li

The membrane-proximal intermolecular disulfide bonds in glycoprotein Ib influence receptor binding to von Willebrand factor.
J. Thromb. Haemost. 6: 1789-1795, 2008. Pubmed

17. S.-Z. Luo, X. Mo, J. A. López, R. Li

Role of the transmembrane domain of glycoprotein IX in assembly of the glycoprotein Ib-IX complex.
J. Thromb. Haemost. 5: 2494-2502, 2007. Pubmed

16. S.-Z. Luoª, X. Moª, V. Afshar-Kharghan, S. Srinivasan, J. A. López, R. Li

Glycoprotein Ibα forms disulfide bonds with 2 glycoprotein Ibβ subunits in the resting platelet.
Blood 109: 603-609, 2007. Pubmed
(with commentary in Blood 109: 393-394)

15. X. Mo, N. Lu, A. Padilla, J. A. López, R. Li

The transmembrane domain of glycoprotein Ibβ is critical to efficient surface expression of glycoprotein Ib-IX complex in the plasma membrane.
J. Biol. Chem. 281: 23050-23059, 2006. Pubmed

14. Z. Tao, Y. Peng, L. Nolasco, S. Cal, C. Lopez-Otin, R. Li, J. F. Moake, J. A. López, J.-F. Dong

Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions.
Blood 106: 4139-4145, 2005. Pubmed

Postdoctoral Work

13. W. Li, D. G. Metcalf, R. Gorelik, R. Li, N. Mitra, V. Nanda, P. B. Law, J. D. Lear, W. F. DeGrado, J. S. Bennett

A push-pull mechanism for regulating integrin function.
Proc. Natl. Acad. Sci. 102: 1424-1429, 2005. Pubmed

12. R. Li, R. Gorelik, V. Nanda, P. B. Law, J. D. Lear, W. F. DeGrado, J. S. Bennett

Dimerization of the transmembrane domain of integrin αIIb subunit in cell membranes.
J. Biol. Chem. 279: 26666-26673, 2004. Pubmed

11. R. Li, J. S. Bennett, W. F. DeGrado

Structural basis for integrin αIIbβ3 clustering.
Biochem. Soc. Trans. 32: 412-415, 2004. Pubmed

10. R. Li, N. Mitra, H. Gratkowski, G. Vilaire, R. Litvinov, C. Nagasami, J. W. Weisel, J. D. Lear, W. F. DeGrado, J. S. Bennett

Activation of integrin αIIbβ3 by modulation of transmembrane helix associations.
Science 300: 795-798, 2003. Pubmed
(commentary in Science 300: 755-756)

9. R. Li, R. H. Hoess, J. S. Bennett, W. F. DeGrado

Use of a phage displayed protein scaffold for determining binding specificity to integrins.
Protein Eng. 16: 65-72, 2003. Pubmed

8. R. Li, C. R. Babu, K. Valentine, J. D. Lear, A. J. Wand, J. S. Bennett, W. F. DeGrado

Characterization of the monomeric form of the transmembrane and cytoplasmic domains of integrin β3 subunit by NMR spectroscopy.
Biochemistry 41: 15618-15624, 2002. Pubmed

5. R. Li, C. R. Babu, J. D. Lear, A. J. Wand, J. S. Bennett, W. F. DeGrado

Oligomerization of the integrin αIIbβ3: roles of the transmembrane and cytoplasmic domains.
Proc. Natl. Acad. Sci. 98: 12462-12467, 2001. Pubmed

Graduate Work

7. R. Li, J. L. Battiste, C. Woodward

Native-like interactions favored in the unfolded bovine pancreatic trypsin inhibitor have different roles in folding.
Biochemistry 41: 2246-2253, 2002. Pubmed

6. J. L. Battiste, R. Li, C. Woodward

A highly destabilizing mutation, G37A, of the bovine pancreatic trypsin inhibitor retains the average native conformation but greatly increases local flexibility.
Biochemistry 41: 2237-2245, 2002. Pubmed

4. K. Akasaka, H. Li, H. Yamada, R. Li, T. Thoresen, C. Woodward

Pressure response of protein backbone structure. Pressure-induced amide 15N-chemical shifts in BPTI.
Protein Sci. 8: 1946-1953, 1999. Pubmed

3. R. Li, C. Woodward

The hydrogen exchange core and protein folding.
Protein Sci. 8: 1571-1590, 1999. Pubmed

2. C. Woodward, R. Li

The slow-exchange core and protein folding.
Trends Biochem. Sci. 23: 379-381, 1998. Pubmed

1. J. Ng, R. Li, K. Morgan, J. Simon

Evolutionary conservation and predicted structure of the Drosophila extra sex combs repressor protein.
Mol. Cell. Biol. 17: 6663-6672, 1997. Pubmed

Once upon a time ...

1,2-Dichloroethane degradation pathway map
Biocatalysis/Biodegradation Database

(ª, co-first author; *, co-corresponding author)