References on engineering memory in living organisms

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Various attempts to implement memory in living organisms have been made on recent years. Here will be a descriptive overview, an soon a comparison of the different systems.


In chronological order.

  • 2000- Gardner et al." Construction of a genetic toggle switch in e. coli." Nature 2000 Jan 20;403(6767):339-42.Click here to read PMID: 10659857

  • 2001-Becskei et al. "Positive feedback in eukaryotic gene networks: cell differentiation by graded to binary response conversion." EMBO J. 2001 May 15;20(10):2528-35.Click here to read PMID 11350942

  • 2003- Atkinson et al. "Development of genetic circuitry exhibiting toggle switch or oscillatory behavior in Escherichia coli." Cell. 2003 May 30;113(5):597-607.Click here to read [1]

  • 2004- kramer et al. "An engineered epigenetic transgene switch in mammalian cells." Nat Biotechnol. 2004 Jul;22(7):867-70.Click here to read PMID 15184906

  • 2005- Kramer and Fussenegger "Hysteresis in a synthetic mammalian gene network." PNAS 2005 Jul 5;102(27):9517-22. Epub 2005 Jun 22. Click here to readPMID 15972812

  • 2005 Vilaboa et al.,"Novel gene switches for targeted and timed expression of proteins of interest." Mol Ther. 2005 Aug;12(2):290-8.Click here to read PMID 15925546

  • 2007 Ingolia and Murray, "Positive-feedback loops as a flexible biological module." Curr Biol. 2007 Jun 5;17(11):R410-2. click here to read PMID 17398098

  • 2007-2008- Ham et al. Invertase based systems
    • "inducible expression system utilizing the fim inversion recombination switch". Biotechnol Bioeng. 2006 May 5;94(1):1-4. click here to read[2]

  • 2008- Ajo-Franklin et al. "Rational design of memory in eukaryotic cells". Genes Dev. 2007 Sep 15;21(18):2271-6. click here to readPMID 17875664

Comparison of the different memory mechanisms used

Back to Jerome's notebook

Back to Endy genetic memory notebook