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Click on the highlighted titles or find papers on PubMed.

Original publications

1. C.J. Hindley*, A.L. Condurat*, V. Menon, R. Thomas, L.M. Azmitia, J.A. Davis, J.Pruszak: The Hippo pathway member YAP enhances human neural crest cell fate and migration. Scientific Reports 2016 6:23208

2. N. Hellbach, S.C. Weise, R. Vezzali, S.D. Wahane, S. Heidrich, D. Roidl, J.Pruszak, J.S. Esser, T. Vogel: Neural deletion of Tgfbr2 impairs angiogenesis through an altered secretome. Human Molecular Genetics 2014 doi:10.1093/hmg/ddu338

3. D.C. Schöndorf, M. Aureli, F.E. McAllister, C.J. Hindley, F. Mayer, B. Schmid, S.P. Sardi, M. Valsecchi, S. Hoffmann, L.K. Schwarz, U. Hedrich, D. Berg, L.S. Shihabuddin, J. Hu, J.Pruszak, S.P. Gygi, S. Sonnino, T. Gasser, M. Deleidi: iPSC-derived neurons from GBA1-associated Parkinson’s disease patients show autophagic defects and impaired calcium homeostasis. Nature Communications 2014 5: 4028. doi:10.1038/ncomms5028

4. G. Turaç, C.J. Hindley, R. Thomas, J.A. Davis, M. Deleidi, T. Gasser, E. Karaöz, J.Pruszak: Combined flow cytometric analysis of surface and intracellular antigens reveals surface molecule markers of human neuropoiesis. PLOS ONE 2013 8(6): e68519. doi:10.1371/journal.pone.0068519

5. A. Rath, A. Klein, A. Papazoglou, J.Pruszak, J. Garcia, M. Krause, J. Maciaczyk, S.B. Dunnett, G. Nikkhah: Survival and Functional Restoration of Human Fetal Ventral Mesencephalon Following Transplantation in a Rat Model of Parkinson's Disease. Cell Transplantation 2013 22(7):1281-93.

6. K. Schlegelmilch*, M. Mohseni*, O. Kirak, J.Pruszak, J.R. Rodriguez, D. Zhou, B.T. Kreger, V. Vasioukhin, J. Avruch, T.R. Brummelkamp, F.D. Camargo: Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation. Cell 2011 144(5):782-95.

7. J.E. Carette*, J.Pruszak*, M. Varadarajan, V.A. Blomen, S. Gokhale, F.D. Camargo, M. Wernig, R. Jaenisch, T.R. Brummelkamp: Generation of iPSCs from cultured human malignant cells. Blood 2010 115(20):4039-42. * equal contribution

8. S. Chung, A. Leung, B.S Han, M.Y. Chang, J.I. Moon, C.H. Kim, S. Hong, J.Pruszak, O. Isacson, K.S. Kim: Wnt1-lmx1a Forms a Novel Autoregulatory Loop and Controls Midbrain Dopaminergic Differentiation Synergistically with the SHH-FoxA2 Pathway. Cell Stem Cell 2009 5(6):646-58.

9. J.Pruszak, W. Ludwig, A. Blak, K. Alavian, O. Isacson: CD15, CD24 and CD29 define a surface biomarker code for neural lineage differentiation of stem cells. Stem Cells 2009 27(12):2928-40.

10. J.Pruszak, L. Just, O. Isacson, G. Nikkhah: Isolation and culture of ventral mesencephalic precursor cells and dopaminergic neurons from rodent brains. Current Protocols in Stem Cell Biology 2009 2D.5:1-21

11. H. Wakimoto, S. Kesari, C.J. Farrell, W.T. Curry WT, C. Zaupa, M. Aghi, T. Kuroda, A. Stemmer-Rachamimov, K. Shah, T.C. Liu, D.S. Jeyaretna, J. Debasitis, J.Pruszak, R.L. Martuza, S.D. Rabkin: Human glioblastoma-derived cancer stem cells: establishment of invasive glioma models and treatment with oncolytic herpes simplex virus vectors. Cancer Research 2009 69(8):3472-81.

12. M. Wernig, J.P. Zhao*, J.Pruszak*, E. Hedlund, D. Fu, F. Soldner, V. Broccoli, M. Constantine-Paton, O. Isacson, R. Jaenisch: Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. PNAS 2008 105(15):5856-61. * equal contribution

13. E.M. Hedlund, J.Pruszak, T. Lardaro, W. Ludwig, A. Viñuela, K.S. Kim, O. Isacson: Embryonic Stem (ES) Cell-derived Pitx3-eGFP Midbrain Dopamine Neurons Survive Enrichment by FACS and Function in an Animal Model of Parkinson's Disease. Stem Cells 2008 26(6):1526-36.

14. J.Pruszak, K.C. Sonntag, M.H. Aung, R. Sanchez-Pernaute, O. Isacson: Markers and Methods for Cell Sorting of Human Embryonic Stem Cell-derived Neural Cell Populations. Stem Cells 2007 25(9):2257-68.

15. G. Brunlid, J.Pruszak, B. Holmes, O. Isacson, K.C. Sonntag: Immature and Neurally Differentiated Mouse ES Cells Do Not Express A Functional Fas/FasL System. Stem Cells 2007 25(10):2551-8.

16. E. Hedlund, J.Pruszak, A. Ferree, A. Viñuela, S. Hong, O. Isacson, K.S.Kim: Selection of embryonic stem cell derived eGFP+ dopamine neurons using the tyrosine hydroxylase promoter is confounded by reporter gene expression in immature cell populations. Stem Cells 2007 25(5):1126-35.

17. K.C. Sonntag, J.Pruszak, T. Yoshizaki, J. van Arensbergen, R. Sanchez-Pernaute, O. Isacson: Enhanced yield of neuroepithelial precursors and midbrain-like dopaminergic neurons from human embryonic stem cells using the BMP antagonist noggin. Stem Cells 2007 25(2):411-8.

18. S. Chung, B.S. Shin, E. Hedlund, J.Pruszak, O. Isacson et al.: Genetic selection of sox1GFP-expressing neural precursors removes residual tumorigenic pluripotent stem cells and attenuates tumor formation after transplantation. J. Neurochem. 2006 97(5):1467-80.

19. K.C. Sonntag, R. Simantov, L. Bjorklund, O. Cooper, J.Pruszak, F. Kowalke, J. Gilmartin, J. Ding, Y.P. Hu, M.M. Shen, O. Isacson: Context-dependent neuronal differentiation and germ layer induction in Smad-/- and Cripto-/- embryonic stem cells. Mol. Cell. Neurosci. 2005 28(3):417-29.

Reviews, book chapters, etc.

20. J.Pruszak (Editor): Neural Surface Antigens - From Basic Biology Towards Biomedical Applications. Elsevier Science & Technology 2015 [Book]

21. V. Menon, R. Thomas, A. Ghale, C. Reinhard, J.Pruszak: Flow cytometry protocols for surface and intracellular antigen analyses of neural cell types. Journal of Visualized Experiments 2014 (94), e52241. [Video Article]

22. J.Pruszak: A brief perspective on neural cell therapy, Molecular and Cellular Therapies 2014 2:2

23. R. Thomas, J.Pruszak: Current Research on Stem Cells in Parkinson’s Disease: Progress and Challenges. [in: Turksen (ed.): "Stem Cells: Current Challenges and New Directions", Stem Cell Biology and Regenerative Medicine, 33:59-84, Springer 2013]

24. M. Döbrössy, J.Pruszak: Neural repair with pluripotent stem cells. [in: Gourdie & Myers (eds.): "Wound Regeneration and Repair: Methods and Protocols, Methods in Molecular Biology", 1037:117-44, Springer 2013]

25. E. Lane, M. Sundberg, J.Pruszak: Stem Cells and Parkinson's Disease. Encyclopedia of Molecular Cell Biology and Molecular Medicine. 2012

26. V. Solozobova, N. Wyvekens, J.Pruszak: Lessons from the Embryonic Neural Stem Cell Niche for Neural Lineage Differentiation of Pluripotent Stem Cells. Stem Cell Reviews and Reports 2012 8:813-829

27. J.Pruszak, M. Döbrössy, J. Kieninger, K. Aravindalochanan, G.A. Urban, G. Nikkhah: Neural stem cells: from cell fate and metabolic monitoring toward clinical applications. [in: Artmann, Minger & Hescheler (eds.): "Stem Cell Engineering: Principles and Applications", Springer 2011 435-456.]

28. J.Pruszak: Dissection: Photographs of a Rite of Passage in American Medicine: 1880-1930. (Book and Media Reviews) JAMA 2010 304:218-220

29. J.Pruszak, O. Isacson: Molecular and cellular determinants for generating ES-cell derived dopamine neurons for cell therapy. Advances in Experimental Medicine and Biology. 2009 651:112-23.

30. J.Pruszak & O. Isacson: Directed Differentiation of Human Embryonic Stem Cells into Dopaminergic Neurons [in: Sullivan, Cowan & Eggan (eds.): "Human Embryonic Stem Cells: The Practical Handbook"; Wiley 2007]

31. S. Karki, J.Pruszak, O. Isacson, K. Sonntag: ES cell-derived neuroepithelial cell cultures Journal of Visualized Experiments 2006 (1), e118. [Video Article]