Patricia McChesney

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Contact Info

Patricia A. McChesney, M.Sc., Ph.D.

Research Associate

Box 800734 Jordan Hall

University of Virginia

Charlottesville, VA 22908-0734


Fedex:

Room 7022 Jordan Hall

University of Virginia

1300 Jefferson Park Ave

Charlottesville, VA 22903


434-243-6296-lab

434-982-1071-fax


Protocols

  1. Cellular Fractionation /Cellular Fractionation

Publications

1, Lee CY, Yoshiki T, Chui L, McChesney P, Herr JC, Hwang ES, Huang ES. (1995) Epitope analysis of a sperm acrosomal antigen defined by HSA-5 monoclonal antibody. J Reprod Immunol. 29:223-38.

2, McChesney PA, Aisner DL, Frank BC, Wright WE, Shay JW. (2000)Telomere Dynamics in Cells with Introduced Telomerase: a Rapid Assay for Telomerase Activity on Telomeres, Mol Cell Biol Res Comm. 3:312-318.

3. Elmore LW, Di Y-M, Akalin A, McChesney PA, Gewirtz DA, Holt SE. (2002)Telomere-Independent Replicative Senescence in Adriamycin-Treated Tumor Cells. J Bio Chem. 227(38): 35509-35515

4. McChesney, PA, Elmore LW, Holt SE. (2002) Aging and Oxidative Damage: Are Telomeres the Target?. Comments On Theoretical Biology. 7:295-313

5. Elmore LW, McChesney PA, Lankowski M, Holt SE (2003) Identification of High Levels of Telomerase in Marine Animals. The Bulletin. 42: 40-42.

6. McChesney PA, Turner KC, Jackson-Cook C, Elmore LW, Holt SE. (2004) Telomerase Resets the Homeostatic Telomere Length and Prevents Telomere Dysfunction in Immortalized Human Cells. DNA and Cell Bio. 23(5):293-300.

7. McChesney PA, Elmore LW, Holt SE. Use of Marine Species as Model Systems for Defining the Regulation of Telomerase and Telomere Biogenesis. (2004) Submitted.

8. Lee OJ, Schnieder-Stock R, McChesney PA, Keuster D, Roessner A, Michael V, Maqani N, El-Rifai W. (2005) Hypermethylation and Loss of Expression of Glutathione Peroxidase-3 in Barrett’s Tumorigenesis. Neoplasia. Sep;7(9):854-61

9. McChesney PA, Aiyar SE, Lee OJ, Zaika A, Li R, El-Rifai W. (2006) COBRA1 is a Novel Transcription Factor Overexpressed in Gastric Adenocarcinoma. Cancer Res. 66 (3):1346-1353.