Moore Notes 8 20 14

Group Call

• Participants: Katie, Tom, Jonathan, Dongying, Guillaume, Josh, Stacia, Stephen, Patrick

• Tom: Does any one know of a tool that visualizes changes in trees over time/space?
  • Idea
    • One big tree with all 16S sequences
    • Identify subtrees for particular data subset (e.g., time points, locations)
    • Assess overlap
  • Similar to comparing diversification across clades in plant/animal literature
  • Cytoscape for visualization

• Fungal allergen mapping
  • Will climate change affect distributions of fungal allergens?
  • 1000 Homes genus-level taxonomic data (16S and ITS)
    • Look at species level (some allergenic, some not in same genus) to see if genus is OK
    • Same problem has come up with pathogens
    • Try all the OTUs within the genera with spatial patterns
    • What is relationship between doorsill dust and actual relative abundance? Same for all genera? All doorsills? Other sites in the home?
    • Do the ITS copy number variations make it hard to infer relative abundance of the taxon?
      • Try presence/absence to see if patterns robust to quantification of abundance
    • Should make maps for other taxa even if we don't know their allergenicity
  • All subsets model selection for each historical climatology
  • Could we try a sequential treatment of climate that integrates over a time period?
  • State is too course resolution for cartograms - try counties
  • What is the story?
    • Focus on specific places, do some validation
    • Many plant associated - expansion of agriculture?
    • Other human-associated factors?
    • Correlations between fungi and bacteria
  • Relationship to Sarah's project looking at longer (geological) time scale effects of climate on bacterial distributions
  • Why do some genera have spatial autocorrelation and others not? What other variables are correlated with having spatial patterns?

• Future calls
  • Next time: Dongying
  • Two weeks: Sarah?