Matt Gethers/Eloranta Ideas/Shikimic Acid

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Shikimic Acid


  1. Bongaerts J, Krämer M, Müller U, Raeven L, and Wubbolts M. Metabolic engineering for microbial production of aromatic amino acids and derived compounds. Metab Eng. 2001 Oct;3(4):289-300. DOI:10.1006/mben.2001.0196 | PubMed ID:11676565 | HubMed [Bongaerts]
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  3. Brown KD and Doy CH. Transport and utilization of the biosynthetic intermediate shikimic acid in Escherichia coli. Biochim Biophys Acta. 1976 May 28;428(3):550-62. DOI:10.1016/0304-4165(76)90183-5 | PubMed ID:6050 | HubMed [Brown]
  4. Dewick PM. The biosynthesis of shikimate metabolites. Nat Prod Rep. 1995 Dec;12(6):579-607. DOI:10.1039/np9951200579 | PubMed ID:8559515 | HubMed [Dewick]
  5. Johansson L, Lindskog A, Silfversparre G, Cimander C, Nielsen KF, and Lidén G. Shikimic acid production by a modified strain of E. coli (W3110.shik1) under phosphate-limited and carbon-limited conditions. Biotechnol Bioeng. 2005 Dec 5;92(5):541-52. DOI:10.1002/bit.20546 | PubMed ID:16240440 | HubMed [Johansson]
  6. Johansson L and Lidén G. Transcriptome analysis of a shikimic acid producing strain of Escherichia coli W3110 grown under carbon- and phosphate-limited conditions. J Biotechnol. 2006 Dec 1;126(4):528-45. DOI:10.1016/j.jbiotec.2006.05.007 | PubMed ID:16828913 | HubMed [Johansson2]
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  8. Knop DR, Draths KM, Chandran SS, Barker JL, von Daeniken R, Weber W, and Frost JW. Hydroaromatic equilibration during biosynthesis of shikimic acid. J Am Chem Soc. 2001 Oct 24;123(42):10173-82. DOI:10.1021/ja0109444 | PubMed ID:11603966 | HubMed [Knop]
  9. Krämer M, Bongaerts J, Bovenberg R, Kremer S, Müller U, Orf S, Wubbolts M, and Raeven L. Metabolic engineering for microbial production of shikimic acid. Metab Eng. 2003 Oct;5(4):277-83. DOI:10.1016/j.ymben.2003.09.001 | PubMed ID:14642355 | HubMed [Kramer]
  10. Park JH and Lee SY. Towards systems metabolic engineering of microorganisms for amino acid production. Curr Opin Biotechnol. 2008 Oct;19(5):454-60. DOI:10.1016/j.copbio.2008.08.007 | PubMed ID:18760356 | HubMed [Park]
  11. Ran N, Draths KM, and Frost JW. Creation of a shikimate pathway variant. J Am Chem Soc. 2004 Jun 9;126(22):6856-7. DOI:10.1021/ja049730n | PubMed ID:15174841 | HubMed [Ran]
  12. Sánchez AM, Bennett GN, and San KY. Novel pathway engineering design of the anaerobic central metabolic pathway in Escherichia coli to increase succinate yield and productivity. Metab Eng. 2005 May;7(3):229-39. DOI:10.1016/j.ymben.2005.03.001 | PubMed ID:15885621 | HubMed [Sanchez]
  13. Sprenger GA. From scratch to value: engineering Escherichia coli wild type cells to the production of L-phenylalanine and other fine chemicals derived from chorismate. Appl Microbiol Biotechnol. 2007 Jun;75(4):739-49. DOI:10.1007/s00253-007-0931-y | PubMed ID:17435995 | HubMed [Sprenger]
  14. Stewart JD. A chemist's perspective on the use of genetically engineered microbes as reagents for organic synthesis. Biotechnol Genet Eng Rev. 1997;14:67-143. DOI:10.1080/02648725.1997.10647940 | PubMed ID:9188151 | HubMed [Stewart]
  15. Yamamoto K, Kataoka E, Miyamoto N, Furukawa K, Ohsuye K, and Yabuta M. Genetic engineering of Escherichia coli for production of tetrahydrobiopterin. Metab Eng. 2003 Oct;5(4):246-54. DOI:10.1016/s1096-7176(03)00046-6 | PubMed ID:14642352 | HubMed [Yamamoto]
  16. Yi J, Draths KM, Li K, and Frost JW. Altered glucose transport and shikimate pathway product yields in E. coli. Biotechnol Prog. 2003 Sep-Oct;19(5):1450-9. DOI:10.1021/bp0340584 | PubMed ID:14524706 | HubMed [Yi]
  17. Yi J, Li K, Draths KM, and Frost JW. Modulation of phosphoenolpyruvate synthase expression increases shikimate pathway product yields in E. coli. Biotechnol Prog. 2002 Nov-Dec;18(6):1141-8. DOI:10.1021/bp020101w | PubMed ID:12467444 | HubMed [Yi2]

All Medline abstracts: PubMed | HubMed