Matt Gethers/20.310 Term Paper

20.310 Term Paper

Sickle Cell Anemia

Treatments exist for preventive and palliative treatment of sickle cell episodes, but no treatment has yet been developed to mitigate the effects of an attack once it has started. We need a way of dealing with Hbs fibers once they have polymerized. We feel we can develop a treatment for an ongoing attack by addressing the biomechanical basis of the pathology.

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DNApol processivity as a function of tension in the strand of template DNA

Processivity

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DNA Stretching

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Miscellaneous

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Phage-based Artificial ECM

Synthetic ECM References

http://dx.doi.org

Development of biocompatible synthetic extracellular matrices for tissue engineering

Byung-Soo Kima and David J. Mooneya, b, doi:10.1016/S0167-7799(98)01191-3

Static and dynamic mechanical properties of extracellular matrix synthesized by cultured chondrocytes

Shogo Miyata a, Corresponding Author Contact Information, E-mail The Corresponding Author, Katsuko S. Furukawa a, Takashi Ushida a, Yasuo Nitta a and Tetsuya Tateishi b doi:10.1016/j.msec.2003.11.007

Stability of hydrogels used in cell encapsulation: An in vitro comparison of alginate and agarose Molly S. Shoichet *, Rebecca H. Li, Melissa L. White, Shelley R. Winn

Transport characterization of hydrogel matrices for cell encapsulation Biotechnology and Bioengineering Volume 50, Issue 4, Date: 20 May 1996, Pages: 365-373 Rebecca H. Li, David H. Altreuter, Frank T. Gentile

26. V.C. Mow, S.C. Kuei, W.M. Lai and C.G. Armstrong. J. Biomech. Eng. 102 (1980), pp. 73–84. View Record in Scopus | Cited By in Scopus (637)

27. C.G. Armstrong, W.M. Lai and V.C. Mow. J. Biomech. Eng. 106 (1984), pp. 165–173. View Record in Scopus | Cited By in Scopus (147)

• Combinatorial and high-throughput measurements of the modulus of thin polymer films

Rev. Sci. Instrum. 76, 062207 (2005); DOI:10.1063/1.1906085 Published 18 May 2005

• High-throughput mechanical characterization of free-standing polymer films

Rev. Sci. Instrum. 76, 062214 (2005); DOI:10.1063/1.1926967 Published 20 May 2005

• Nanomechanical property screening of combinatorial thin-film libraries by nanoindentation

OL Warren, TJ Wyrobek - Measurement Science and Technology, 2005 - iop.org

• Techniques and Instrumentation for Combinatorial and High-Throughput Polymer Research: Recent Developments

Stefan Schmatloch, Ulrich S. Schubert *

• Microrheology as a tool for high-throughput screening V. Breedveld1 and D. J. Pine

• Multi-sample Couette viscometer for

polymer formulations∗ Howard J Walls1,3, Robert F Berg2 and Eric J Amis1

• Combinatorial studies of mechanical properties of Ti–Al thin films using nanoindentation

Seung Min Hana, Corresponding Author Contact Information, E-mail The Corresponding Author, R. Shaha, R. Banerjeeb, G.B. Viswanathanb, B.M. Clemensa and W.D. Nixa

• http://www.mtsnano.com/products/xpw/ - Automated Nano Indenter

• Elastic modulus and hardness of cortical and trabecular bone lamellae measured by nanoindentation in the human femur

Philippe K. ZyssetCorresponding Author Contact Information, E-mail The Corresponding Author, X. Edward Guo, C. Edward Hoffler, Kristin E. Moore and Steven A. Goldstein

• Characterization of viscoelastic properties of polymeric materials through nanoindentation G. M. Odegard1 Contact Information, T. S. Gates2 and H. M. Herring2

• Chondrocytes in agarose culture synthesize a mechanically functional extracellular matrix

Michael D. Buschmann 1, Yehezkiel A. Gluzband 1, Dr. Alan J. Grodzinsky 1 *, James H. Kimura 2, Ernst B. Hunziker 3

• Streaming potentials during the confined compression creep test of normal and proteoglycan-depleted cartilage Albert C. Chen2, 1, Tara T. Nguyen2, 1 and Robert L. Sah2, 1

• Depth- and strain-dependent mechanical and electromechanical properties of full-thickness bovine articular cartilage in confined compression

A. C. Chen, W. C. Bae, R. M. Schinagl and R. L. SahCorresponding Author Contact Information, E-mail The Corresponding Author

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