Lloyd M. Smith Lab:Publications, Talks & Media

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Recent Publications

  1. Lockett MR, Shortreed MR, and Smith LM. Aldehyde-terminated amorphous carbon substrates for the fabrication of biomolecule arrays. Langmuir. 2008 Sep 2;24(17):9198-203. DOI:10.1021/la800991t | PubMed ID:18672922 | HubMed [Paper1]
  2. Freed JK, Shortreed MR, Kleefisch CJ, Smith LM, and Greene AS. Revealing the role of phosphatidylserine in shear stress-mediated protection in endothelial cells. Endothelium. 2008 Jul-Aug;15(4):225-30. DOI:10.1080/10623320802228849 | PubMed ID:18663626 | HubMed [Paper2]
  3. Lockett MR, Weibel SC, Phillips MF, Shortreed MR, Sun B, Corn RM, Hamers RJ, Cerrina F, and Smith LM. Carbon-on-metal films for surface plasmon resonance detection of DNA arrays. J Am Chem Soc. 2008 Jul 9;130(27):8611-3. DOI:10.1021/ja802454c | PubMed ID:18597426 | HubMed [Paper3]
  4. Westphall MS, Jorabchi K, and Smith LM. Mass spectrometry of acoustically levitated droplets. Anal Chem. 2008 Aug 1;80(15):5847-53. DOI:10.1021/ac800317f | PubMed ID:18582090 | HubMed [Paper4]
  5. Jorabchi K, Westphall MS, and Smith LM. Charge assisted laser desorption/ionization mass spectrometry of droplets. J Am Soc Mass Spectrom. 2008 Jun;19(6):833-40. DOI:10.1016/j.jasms.2008.02.012 | PubMed ID:18387311 | HubMed [Paper5]
  6. Smith LM. Is charge reduction in ESI really necessary?. J Am Soc Mass Spectrom. 2008 May;19(5):629-31. DOI:10.1016/j.jasms.2008.02.002 | PubMed ID:18374599 | HubMed [Paper6]
  7. Zhang X, Scalf M, Westphall MS, and Smith LM. Membrane protein separation and analysis by supercritical fluid chromatography-mass spectrometry. Anal Chem. 2008 Apr 1;80(7):2590-8. DOI:10.1021/ac702319u | PubMed ID:18303916 | HubMed [Paper7]
  8. Murray JK, Sadowsky JD, Scalf M, Smith LM, Tomita Y, and Gellman SH. Exploration of structure--activity relationships among foldamer ligands for a specific protein binding site via parallel and split-and-mix library synthesis. J Comb Chem. 2008 Mar-Apr;10(2):204-15. DOI:10.1021/cc700153z | PubMed ID:18275161 | HubMed [Paper8]
  9. Phillips MF, Lockett MR, Rodesch MJ, Shortreed MR, Cerrina F, and Smith LM. In situ oligonucleotide synthesis on carbon materials: stable substrates for microarray fabrication. Nucleic Acids Res. 2008 Jan;36(1):e7. DOI:10.1093/nar/gkm1103 | PubMed ID:18084027 | HubMed [Paper9]
  10. Lockett MR, Phillips MF, Jarecki JL, Peelen D, and Smith LM. A tetrafluorophenyl activated ester self-assembled monolayer for the immobilization of amine-modified oligonucleotides. Langmuir. 2008 Jan 1;24(1):69-75. DOI:10.1021/la702493u | PubMed ID:18047381 | HubMed [Paper10]
  11. Lee JE, Didier DN, Lockett MR, Scalf M, Greene AS, Olivier M, and Smith LM. Characterization of vascular endothelial growth factor receptors on the endothelial cell surface during hypoxia using whole cell binding arrays. Anal Biochem. 2007 Oct 15;369(2):241-7. DOI:10.1016/j.ab.2007.06.010 | PubMed ID:17624292 | HubMed [Paper11]
  12. Lockett MR, Shortreed MR, and Smith LM. Molecular beacon-style hybridization assay for quantitative analysis of surface invasive cleavage reactions. Anal Chem. 2007 Aug 1;79(15):6031-6. DOI:10.1021/ac070424c | PubMed ID:17595056 | HubMed [Paper12]
  13. Chen S, Zheng T, Shortreed MR, Alexander C, and Smith LM. Analysis of cell surface carbohydrate expression patterns in normal and tumorigenic human breast cell lines using lectin arrays. Anal Chem. 2007 Aug 1;79(15):5698-702. DOI:10.1021/ac070423k | PubMed ID:17580952 | HubMed [Paper13]
  14. Hilger RT, Westphall MS, and Smith LM. Controlling charge on levitating drops. Anal Chem. 2007 Aug 1;79(15):6027-30. DOI:10.1021/ac070413j | PubMed ID:17580951 | HubMed [Paper14]
  15. Lamos SM, Shortreed MR, Frey BL, Belshaw PJ, and Smith LM. Relative quantification of carboxylic acid metabolites by liquid chromatography-mass spectrometry using isotopic variants of cholamine. Anal Chem. 2007 Jul 15;79(14):5143-9. DOI:10.1021/ac062416m | PubMed ID:17563114 | HubMed [Paper15]
  16. Zheng T, Yu H, Alexander CM, Beebe DJ, and Smith LM. Lectin-modified microchannels for mammalian cell capture and purification. Biomed Microdevices. 2007 Aug;9(4):611-7. DOI:10.1007/s10544-007-9074-2 | PubMed ID:17516171 | HubMed [Paper16]
  17. Sun B, Colavita PE, Kim H, Lockett M, Marcus MS, Smith LM, and Hamers RJ. Covalent photochemical functionalization of amorphous carbon thin films for integrated real-time biosensing. Langmuir. 2006 Nov 7;22(23):9598-605. DOI:10.1021/la061749b | PubMed ID:17073485 | HubMed [Paper17]
  18. Shortreed MR, Lamos SM, Frey BL, Phillips MF, Patel M, Belshaw PJ, and Smith LM. Ionizable isotopic labeling reagent for relative quantification of amine metabolites by mass spectrometry. Anal Chem. 2006 Sep 15;78(18):6398-403. DOI:10.1021/ac0607008 | PubMed ID:16970314 | HubMed [Paper18]
  19. Peelen D, Kodoyianni V, Lee J, Zheng T, Shortreed MR, and Smith LM. Specific capture of mammalian cells by cell surface receptor binding to ligand immobilized on gold thin films. J Proteome Res. 2006 Jul;5(7):1580-5. DOI:10.1021/pr050467e | PubMed ID:16823965 | HubMed [Paper19]
  20. Lamos SM, Krusemark CJ, McGee CJ, Scalf M, Smith LM, and Belshaw PJ. Mixed isotope photoaffinity reagents for identification of small-molecule targets by mass spectrometry. Angew Chem Int Ed Engl. 2006 Jun 26;45(26):4329-33. DOI:10.1002/anie.200600743 | PubMed ID:16733838 | HubMed [Paper20]
  21. Smith LM. Nanostructures: the manifold faces of DNA. Nature. 2006 Mar 16;440(7082):283-4. DOI:10.1038/440283a | PubMed ID:16541053 | HubMed [Paper21]
  22. Nie B, Shortreed MR, and Smith LM. Quantitative detection of individual cleaved DNA molecules on surfaces using gold nanoparticles and scanning electron microscope imaging. Anal Chem. 2006 Mar 1;78(5):1528-34. DOI:10.1021/ac052067g | PubMed ID:16503604 | HubMed [Paper22]
  23. Zhang X, Scalf M, Berggren TW, Westphall MS, and Smith LM. Identification of mammalian cell lines using MALDI-TOF and LC-ESI-MS/MS mass spectrometry. J Am Soc Mass Spectrom. 2006 Apr;17(4):490-499. DOI:10.1016/j.jasms.2005.12.007 | PubMed ID:16488154 | HubMed [Paper23]
  24. Shortreed MR, Chang SB, Hong D, Phillips M, Campion B, Tulpan DC, Andronescu M, Condon A, Hoos HH, and Smith LM. A thermodynamic approach to designing structure-free combinatorial DNA word sets. Nucleic Acids Res. 2005;33(15):4965-77. DOI:10.1093/nar/gki812 | PubMed ID:16284197 | HubMed [Paper24]
  25. Nie B, Shortreed MR, and Smith LM. Scoring single-nucleotide polymorphisms at the single-molecule level by counting individual DNA cleavage events on surfaces. Anal Chem. 2005 Oct 15;77(20):6594-600. DOI:10.1021/ac051025p | PubMed ID:16223245 | HubMed [Paper25]
  26. Frey BL, Lin Y, Westphall MS, and Smith LM. Controlling gas-phase reactions for efficient charge reduction electrospray mass spectrometry of intact proteins. J Am Soc Mass Spectrom. 2005 Nov;16(11):1876-87. DOI:10.1016/j.jasms.2005.07.019 | PubMed ID:16198118 | HubMed [Paper26]
  27. Murray JK, Farooqi B, Sadowsky JD, Scalf M, Freund WA, Smith LM, Chen J, and Gellman SH. Efficient synthesis of a beta-peptide combinatorial library with microwave irradiation. J Am Chem Soc. 2005 Sep 28;127(38):13271-80. DOI:10.1021/ja052733v | PubMed ID:16173757 | HubMed [Paper27]
  28. Tulpan D, Andronescu M, Chang SB, Shortreed MR, Condon A, Hoos HH, and Smith LM. Thermodynamically based DNA strand design. Nucleic Acids Res. 2005;33(15):4951-64. DOI:10.1093/nar/gki773 | PubMed ID:16145053 | HubMed [Paper28]
  29. Zheng T, Peelen D, and Smith LM. Lectin arrays for profiling cell surface carbohydrate expression. J Am Chem Soc. 2005 Jul 20;127(28):9982-3. DOI:10.1021/ja0505550 | PubMed ID:16011345 | HubMed [Paper29]
  30. Book AJ, Yang P, Scalf M, Smith LM, and Vierstra RD. Tripeptidyl peptidase II. An oligomeric protease complex from Arabidopsis. Plant Physiol. 2005 Jun;138(2):1046-57. DOI:10.1104/pp.104.057406 | PubMed ID:15908606 | HubMed [Paper30]
  31. Chen Y, Shortreed MR, Olivier M, and Smith LM. Parallel single nucleotide polymorphism genotyping by surface invasive cleavage with universal detection. Anal Chem. 2005 Apr 15;77(8):2400-5. DOI:10.1021/ac0483825 | PubMed ID:15828773 | HubMed [Paper31]
  32. Rabaglia ME, Gray-Keller MP, Frey BL, Shortreed MR, Smith LM, and Attie AD. Alpha-Ketoisocaproate-induced hypersecretion of insulin by islets from diabetes-susceptible mice. Am J Physiol Endocrinol Metab. 2005 Aug;289(2):E218-24. DOI:10.1152/ajpendo.00573.2004 | PubMed ID:15741243 | HubMed [Paper32]
  33. Peelen D and Smith LM. Immobilization of amine-modified oligonucleotides on aldehyde-terminated alkanethiol monolayers on gold. Langmuir. 2005 Jan 4;21(1):266-71. DOI:10.1021/la048166r | PubMed ID:15620313 | HubMed [Paper33]
  34. Su X and Smith LM. Demonstration of a universal surface DNA computer. Nucleic Acids Res. 2004;32(10):3115-23. DOI:10.1093/nar/gkh635 | PubMed ID:15181177 | HubMed [Paper34]
  35. Lu M, Knickerbocker T, Cai W, Yang W, Hamers RJ, and Smith LM. Invasive cleavage reactions on DNA-modified diamond surfaces. Biopolymers. 2004 Apr 5;73(5):606-13. DOI:10.1002/bip.20007 | PubMed ID:15048784 | HubMed [Paper35]
  36. Chen Y, Shortreed MR, Peelen D, Lu M, and Smith LM. Surface amplification of invasive cleavage products. J Am Chem Soc. 2004 Mar 17;126(10):3016-7. DOI:10.1021/ja039355j | PubMed ID:15012108 | HubMed [Paper36]
  37. Chen X, Westphall MS, and Smith LM. Mass spectrometric analysis of DNA mixtures: instrumental effects responsible for decreased sensitivity with increasing mass. Anal Chem. 2003 Nov 1;75(21):5944-52. DOI:10.1021/ac030127h | PubMed ID:14588036 | HubMed [Paper37]
  38. Yang W, Auciello O, Butler JE, Cai W, Carlisle JA, Gerbi JE, Gruen DM, Knickerbocker T, Lasseter TL, Russell JN Jr, Smith LM, and Hamers RJ. DNA-modified nanocrystalline diamond thin-films as stable, biologically active substrates. Nat Mater. 2002 Dec;1(4):253-7. DOI:10.1038/nmat779 | PubMed ID:12618788 | HubMed [Paper38]
  39. Berggren WT, Westphall MS, and Smith LM. Single-pulse nanoelectrospray ionization. Anal Chem. 2002 Jul 15;74(14):3443-8. DOI:10.1021/ac010975h | PubMed ID:12139052 | HubMed [Paper39]
  40. Lu M, Hall JG, Shortreed MR, Wang L, Berggren WT, Stevens PW, Kelso DM, Lyamichev V, Neri B, Skinner JL, and Smith LM. Structure-specific DNA cleavage on surfaces. J Am Chem Soc. 2002 Jul 10;124(27):7924-31. DOI:10.1021/ja012082c | PubMed ID:12095336 | HubMed [Paper40]
  41. Berggren WT, Takova T, Olson MC, Eis PS, Kwiatkowski RW, and Smith LM. Multiplexed gene expression analysis using the invader RNA assay with MALDI-TOF mass spectrometry detection. Anal Chem. 2002 Apr 15;74(8):1745-50. DOI:10.1021/ac011167t | PubMed ID:11985304 | HubMed [Paper41]
  42. Lu M, Shortreed MR, Hall JG, Wang L, Berggren T, Stevens PW, Kelso DM, Lyamichev V, Neri B, and Smith LM. A surface invasive cleavage assay for highly parallel SNP analysis. Hum Mutat. 2002 Apr;19(4):416-22. DOI:10.1002/humu.10071 | PubMed ID:11933196 | HubMed [Paper42]

All Medline abstracts: PubMed | HubMed