I obtained my PhD in Molecular Biology from Murdoch University in Perth, Western Australia, where I investigated downstream target genes of the T-ALL associated oncoprotein, HOX11. The focus of my research in Dr Licht's laboratory is to identify specific target genes directly regulated by PLZF and the t(11;17) APL associated oncogenic fusion, PLZF-RARa, and thereby unravel the molecular mechanisms underlying the role of these proteins in normal hematopoiesis and in leukemogenesis.
In my very limited spare time (!) I enjoy reading E.M Forster, Oscar Wilde and David Sedaris, making a mess in the kitchen and exploring Chicago.
Doulatov S, Notta F, Rice KL, Howell L, Zelent A, Licht JD, Dick JE. (2009). PLZF is a regulator of homeostatic and cytokine-induced myeloid development. Genes Dev. 23(17):2076-87.
Rice, K.L., Hormaeche, I., Licht, J.D. “The Promyelocytic Leukemia Zinc Finger Protein.” Focus on Zinc Finger Protein Research, India, Research Signpost. 2009.
Rice, KL., Hormaeche, I., Licht, JD. (2007). Epigenetic regulation of normal and malignant hematopoiesis. Oncogene, 26 (47):6697-714.
Rice, KL., Licht, JD. (2007). Hox deregulation – A common theme in acute myeloid leukemia. The Journal of Clinical Investigation, 117 (4): 865-8.
Rice, KL., Izon, DJ., Ford, J., Boodhoo, A., Kees, UR., Greene, W.K. (2007). Overexpression of stem cell associated ALDH1A1, a target of the leukemogenic transcription factor TLX1/HOX11, inhibits lymphopoiesis and promotes myelopoiesis in murine hematopoietic progenitors. Leukemia Research, 32(6):873-83.
Rice, KL., Kees, UR., Greene, WK. (2007). Transcriptional Regulation of FHL1 by TLX1/HOX11 is dosage, cell-type and promoter context-dependent. Biochem Biophys Res Commun. 367(3):707-13.
Heidari, M., Rice, KL., Phillips, JK., Kees, UR., Greene, WK. (2006), The nuclear oncoprotein TLX1/HOX11 associates with pericentromeric satellite 2 DNA in leukemic T-cells. Leukemia, 20(2): 304-12.
Heidari, M., Rice, KL., Kees, UR., Greene, WK. (2002), Expression and purification of the human homeodomain oncoprotein HOX11. Protein Expression and Purification, (25): 313-318.
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