Keck Subbasement:Reading

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Oscillators

1. Elowitz MB and Leibler S. A synthetic oscillatory network of transcriptional regulators. Nature. 2000 Jan 20;403(6767):335-8. DOI:10.1038/35002125 |

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Delays

This theory paper investigates how delays destabilize fixed points. This is a fundamentally different analysis, quite the opposite of trying to use delays to make limit cycles more attractive.

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This is not transcriptional delay, but rather delay through intermediate species, which is the principle that dominates previous delay studies.

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This experimental paper uses a plasmid that effectively contains a delay, used for another purpose entirely, but might be a good starting point for design.

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Plasmid Design

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Testing delays

This paper measures transfer curves and dynamics of a simple circuit

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Metastable hairpins

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