We are investigating the role of basic helix-loop-helix (bHLH)transcription factors in differentiation and cell-type specification of neural subtypes. By determining the downstream targets of Atoh1, Neurog1/2, Ascl1, and Ptf1a, we hope to elucidate a cis-regulatory code for these transcription factors. In addition, by lineage tracing these factors, we hope to assess the ultimate cell fate of the neural subtypes they specify.
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Image:JaneJohnsonLabMath1.jpg|LacZ expression in the Atoh1 domains
Image:Nakada.png|GFP expression in the Neurog1 domains
Image:Battiste.png|LacZ expression in the Ascl1 domains
Image:Glasgow.png|LacZ expression in the Ptf1a domains