Imported:YPM/Mutants for fitting model

Category:Yeast Pheromone Response Model Back to main model page

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• Effect of deleting Ste2, Ste5, Fus3, Kss1, and Fus3 and Kss1 on expression of FUS1-LacZ in figure 5 of Crosby et al. 2000 PMID 11054817

• Effect of Kss1 deletion or non-phosphorylatable Kss1 on Fus1-LacZ expression at several time points in figure 3 of Sabbagh et al. 2001 PMID 11583629

• Effect of Fus3 deletion on Fus1-LacZ and FRE-LacZ expression at several time points in figure 4b of Sabbagh et al. 2001 PMID 11583629

• Effect of Fus3 and Kss1 deletions in tandem with non-phosphorylatable Tec1 on filamentous gene expression in fig 5 of Chou et al. 2004 PMID 15620356

• Effect of Fus3 deletion along with non-phosphorylatable Tec1 on filamentous gene expression in fig 6a-d of Bao et al. 2004 PMID 15620357

• Activity of pheromone-responsive reporter gene (8 tandem copies of PRE driving lacZ) in absence of pheromone is altered by pathway mutations. Hasson et al. 1994 PMID 8289786
  • down about 10-fold when ste4, ste18, or ste5 is mutated
  • down about 100-fold when ste7, ste11, or ste12 is mutated
  • up about 3-fold when ste2 is mutated

• Deletion of Ptp2 results in no detectable change in pheromone-induced Fus3 activity, deletion of Ptp3 results in a 2-fold increase in pheromone-induced Fus3 activity, and double deletion of Ptp2 and Ptp3 results in a 3-fold increase in pheromone-induced Fus3 activity. See figures 3a and 6a in Zhan et al. 1997 PMID 9224718