Imported:YPM/MAPK pT only Kd factor

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Category:Parameters - Yeast Pheromone Response Model Back to main model page 


<modelParameter>MAPK_pT_only_Kd_factor = MAPK_pY_only_Kd_factor</modelParameter>

Definition

This is the factor by which phosphorylation of Fus3 or Kss1 on just the threonine decreases its affinity for a target, compared to the affinity of doubly phosphorylated Fus3 or Kss1 for that same target.
Kd_MAPKpT_target = MAPK_pT_only_Kd_factor * Kd_MAPKpTpY_target
MAPK_pT_only_Kd_factor > 1 means that MAPKpT binds its targets more weakly than MAPKpTpY.

Source

  • Experimentally measured for ERK2pT phosphorylation of MBP and ELK1, and found to be the same as for ERK2pY.

Trust

  • Medium

Additional Details

See MAPK/target interaction properties for more details.

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