IGEM:IMPERIAL/2009/EncapsulationP3 Trigger

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The trigger for the cell death is heavily dependant on the project application and the cell encapsulation mechanism. Possible ideas proposed include:

  • Hypoxic conditions caused by complete encapsulation in a compound through which oxygen cannot diffuse (not for the alginate capsule, only the CaCO3/ salt capsule)
  • Timer mechanism continuing from drug production timer/threshold
  • External factor added manually to trigger genetic removal response.
  • Environmental Sensor mechanism, different environment once capsule has been formed. depends on capsule again
  • RNA thermometer (biobrick characterised by TU Delft '08)

II09 TUDtherm.jpg