IGEM:Harvard/2006/Brainstorming 6 12

June 12, 2006

DNA nanostructures

• opening/closing dynamically using DNA sticky ends or DNA binding protein, investigating protein design
• make a tight box
• making a latch to be opened by a certain receptor

Global warming

• cyanobacteria - circadian oscillator -> synthetic oscillator
• neurospora - light sensitive repressor

Computer Analogies

• Memory
  • plasmid memory, memory management, garbage collection/mark and sweep
  • addressable
• Counter
  • telomeres, buffer with red flourescent protein or a self-destruction sequence
• Cryptography
  • fold DNA nanostructure - key is native strand of DNA in one cell, message of oligomers sent to that cell
• Debugger
  • something before the reporter
  • making a bunch of parameters and seeing what we can get
  • perhaps working a debugger into our specific system

Alternative splicing

• Hijacking commensal bacteria
• Yogurt - lactobacillusacidophillus

Ftsk translocase

• simple manipulations of DNA, spitting DNA into media

Fuel production

• Ethanol in yeast or E.coli

Biobricks in eukaryotes

• protein domain system (MCB 100 work)

Message Relay System

• Passing molecules
• Assembling messages

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Notes from first meeting (pdf)