Just on the day that the iGEM China ambassadors came to the Peking University, Dec 28th, 2006, we, approximately ten undergraduates and a couple of graduates of PKU,founded the iGEM PKU team. After several times of expansion, 20 students and 2 leading teachers and several other advisors are actively contributing to our team, yet formal enrollment has not been ruled out.
The two leading teachers of our team are Prof. Yiping Wang from Life Science College and Dr. Fangting Li from Center for Theoretical Biology. They will not only provide us with beneficial instructions through out the competition, but also will represent our team to attend “Teach the teachers” this June and lead us to the jamboree held in MIT this November. Besides the two teachers mentioned above, three additional advisors, Prof. Qi Ouyang from Center for Theoretical Biology as well as College of Physics, Dr. Luhua Lai from Center for Theoretical Biology and College of Chemistry and Molecular Engineering as well, and Prof. Jin Xu from School of Electronic Engineering and Computer Science, would like to make joint efforts to help us with more constructive directions, too. Since our team is under rapid development, it is believed that a increasing number of teachers would join us in the future.
Dec. 28th 2006 iGEM-PKU was founded and the organization of team activities was primarily discussed
Jan. 14th , 2007 the first team journal club was held
In order to improve the performance of iGEM-PKU both systematically and sustainingly, the team has applied to the university for the foundation of “iGEM society”.
We have already gone through the first two checkups and are now preparing for the final examination diligently. If we succeed, all team routines will be proceeding under the name of PKU-iGEM, offering convenience for the advancement of our competition and further propagandization of synthetic biology in Peking University.
In the past 5 weeks, our weekly journal has been focusing on the discussion of project ideas. We have proposed 6 projects and many more are being prepared. The full list of proposed ideas can be visited at our Wiki: http://wiki.igempku.cn/index.php/Project_ideas . This part of the wiki is under extensive development and is updated on a daily basis.
Our wiki is at http://wiki.igempku.cn . You can get a great deal of information involving basic team background and latest news for our activities. We contact with each other through Google Talk: email@example.com, we also have a website for this e-mail collection: http://groups.google.com/group/igem
As the school motto “Self-discipline and Social Commitment” reflects, Tsinghua University iGEM 2007 team is focusing on endeavor and creativity as well as teamwork
and responsibility in the process of cooperating with the others to accomplish a goal. The team consists of two supervisors, three advisors, eight members and the
desire to explore the world of synthetic biology.
Prof. Chen Guoqiang Dr. Xu Feng
Liu Zhe: PhD student in Laboratory of Structural Biology, Tsinghua University Shi Zhenyu: Senior undergraduate student majoring in fundamental science (Chemistry and Biology) Song Xindong: PhD student in Medical Systems Biology Research Center
Chen Chen: Senior undergraduate majoring in Biology Dong Peng: PhD student in Medical Systems Biology Research Center Jiang Ming: Junior undergraduate majoring in Electronic Engineering Liu Yexing: Junior undergraduate majoring in Biology Li Keyu: Junior undergraduate majoring in Biology Yu Zhou: unior undergraduate majoring in Biology Zhao Xinyu: enior undergraduate majoring in Biology Zhou Lijun: Junior undergraduate majoring in Biology
Prof. Chen Guoqiang kindly provides us working space and reagents for experiments in his lab of Microbiology, Tsinghua University
How much can we disturb or control the communication between microorganisms in tremendous amount? Perhaps a chain carrying signals that we want to bruit is possible
to be constructed in the society of E. coli. Then we can gain a closer insight into those tiny lives.
According to former work in the realm of Oscillator, we are inspired to design special gene sequence that can endow E. coli periodical reaction in certain forms to
certain signals, which can be derived from other cells or be opposed artificially.
The following is the contact of the Tsinghua University iGEM 2007 team. Please feel free to contact us, we would be more than happy to communicate with you. Your
advice and suggestions are welcome and would be highly appreciated.
With the great passion, innovative ideas and team work spirit, students from Tianjin University Team 1 are actively participating in this competition. We explain the
iGEM competition as an international platform to show our great passion, energetic, most creative. Sound financial and technological strength is what we rely on to do
a good job in this competition. We all have great power and are filled with confidence. Just to say “Go on, we will succeed”.
Prof. Yuan Yingjin
Dr. Cheng Jingsheng
Dr. Song Kai
Li Bingzhi: PhD student majoring in Biochemical Engineering
Wang Honglei: Graduate student majoring in Chemical Engineering
Hu Bo: Graduate student majoring in Biochemical Engineering
Wang Xing: Graduate student majoring in pharmaceutical Engineering
Zhou Jian: Graduate student majoring in pharmaceutical Engineering
Shi Lei: Graduate student majoring in Biochemical Engineering
Sun jingjing: Senior undergraduate majoring in Bioengineering
Li Xiaoqian: Senior undergraduate majoring in Bioengineering
Zhu Manli: Senior undergraduate majoring in Bioengineering
Zou ruiyang: Senior undergraduate majoring in Molecular Science and Technology
Qiao Kangjian: Senior undergraduate majoring in Chemical Engineering
Chen Zheng: Senior undergraduate majoring in Chemical Engineering
Lab and Funding
Prof. YJ Yuan kindly provides experiment environment and most of the financial support.
Also our team gets the financial support from the National Natural Science Foundation of China and the Tianjin University.
FLIP FLOP, ENCODER, CLOCK, much of them come from the electrocircuit consideration.
two fluorescence reporters, we can monitor the reaction direction by the colour varying.
states of cell infected by phage and using different reporter according to the different state.
change is needed. Because biological system is unpredictable and couldn’t control strictly as electrocircuit, there are still many problems we must face. We proceed with all the ideas
but focus on the most feasible.
Besides the logic application in our biological machine, we also hope to find other inspiration in energy and medicine issues. Surely, we get closer and closer to the
We are looking forward to your attention to our team
We come from Tianjin University, one of the most famous universities in China. Our team is composed of fifteen creative young people with enormous passion for
synthetic biology. The solid foundation of professional knowledge provides us firm confidence, and the enthusiastic research spirit gives us the courage to challenge
the mystery of science. We believe that everything can be possible with our endeavor and wisdom.
Binbin Han PHD of biochemical engineering
Xiaowen Hou major in biological engineering
Prof. X.M. Zhao
Lab and funding
Prof. X.M. Zhao is kind enough to provide ‘wet’ experiments environment and ‘dry’ experiment equipment for us.
ene circuit The aim of our project is to simulate electrocircuit in series and parallel connection by gene elements. Series circuit and parallel circuit are the simplest circuits
in physics. There are three eletments in it: switch, power and resistance. What we should do is to construct three kinds of bacterials functioning as the three
elements in electrocircuit, seperately: one for power, the other two for resistances(R1 and R2). Light is used as a switch. The gene circuit is connected when the
bacterials are supposed to light so that the flurescence proteins with different colors in the three kind of bacterials are all expressed, while the circuit is cut
when we turn the light off. In series circuit, If we cut any of the resistances or power, it will result in the disconnection of the whole circuit, while in parallel
circuit, the lack of one resistance will not influence the other one. Three different kinds of HSL are used as the cell to cell signals.
Bacterial neon light In this project ,we use gene circle to create a bacterial neon light with three different colors. the first repressor protein, LacI from E. coli, inhibits the
transcription of the second repressor gene, tetR from the tetracycline-resistance transposon Tn10, whose protein product in turn inhibits the expression of a third
gene, cI from λ phage. Finally, CI inhibits lacI expression, completing the cycle. The three repressors are connected with red, green, and yellow luc genes (a kind
of luminescent gene) seperately. With the oscillation of the gene circle, the three colors of light will show up circularly, just as a neon light.
The following is the contact of the iGEM TJU 2007 team. Your advices and suggestions are welcome and highly appreciated.
Coming from various departments of Tianjin University, which is famous for precise attitude in researching, we formed this vigorous team three months ago. Albeit we have different background in university, there is one thing in common, that is, great interests in synthesis biology and eager to build a genetically engineered machine by ourselves. We know exactly how difficult it will be. However, we have a lot of confidence, because we believe in ‘attitude is everything’, and every problems will be solved with our zest.
Lin Liu, PHD student in Laboratory of Biochemical Reaction Engineering
Wei Zhu, major in Biochemical Engineering
Professor Jianping Wen
Lab and funding
Professor Jianping Wen and Yingjin Yuan are very interested in our ideas, and suggest that they will provide us everything we need in both experiment and simulation.
Ever since the first discussion among our three teams on Jan. 23rd, we have learned a lot about the synthesis biology and have discussed a lot about our own project. Meanwhile, we at times invited the other two teams to have some discussion so that we would both obtain process. Up till now, ample preparation has been made in both experimentation and simulation. We are apoise to face the future challenge, and we have confidence to smile in the end of the 2007 iGEM.
The following is the contact of the iGEM TJU 2007 team. Your suggestions will be expected and appreciated.
We come from USTC, one of the most famous universities in China. We are the combination of the exact tradition of USTC and the exact vitality of the young. Rigorous
daily schoolwork has provided us with a solid foundation of basic knowledge, and an innovative spirit enables us to stand on the frontier of the modern science. Our
belief is'Never to say failur'.
Zhan Jian : PHD candidate in Key Laboratory of Structural Biology
Su Xiaofeng: major in molecular and cellular Biology
Prof. H.Y. Liu
Lab and funding
Prof. J.R. Wu is kind enough to provide ‘wet’ experiments environment.
Despite the exciting advancement in recent years, phage contamination is still one of the headaches that nowadays the food and fermentation industries mainly
confront. Some strains with genotype like TonA is resistant to T1-like bacteriophages, but the productive performance of these strains is low because of the slow
growth rates. Therefore, the producer is facing a dilemma: how can we deal with the strains lacking phage resistance, but with high productivity, and strains with
certain kind of phage resistance but the productivity of which is rather low.
will switch on the expression of TonA , making themselves resistant to the enemy.
to increase fast after the infection. Secondly, how to switch on the expression of TonA? The response should be as quick as possible, or the enemy will invade in
without any resistance!
commits suicide to avoid the propagation of the phages, and without influencing the others.
The following is the contact of the iGEM USTC 2007 team. Your advice and suggestions are welcome and highly appreciated.