Gautier Lab:Research Interests

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Gautier Lab, Columbia University

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Research Interests

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We use the Xenopus laevis cell-free extracts system to study processes in DNA replication and repair.

We are interested in

  • elucidating the mechanisms of ATM activation
  • studying the role of the Mre11-Rad50-Nbs1 complex in double-strand break repair
  • using cell-free extracts to identify small molecules that modulate DNA replication, DNA repair or the DNA damage response
  • studying the role of Fanconi anemia proteins in DNA replication and repair
  • defining the mechanism of double-strand break resection with a focus on the role of CtIP
  • studying the role of BRCA1/BARD1 in the DNA damage response
  • understanding the regulation of DNA replication by MCM proteins
  • understanding the mechanism by which cMYC regulates DNA replication

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