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GSFL - Publications


McHugh, P.C., Joyce, P.R., Kennedy, M.A. (2009) Polymorphisms of sepiapterin reductase gene alter promoter activity and may influence risk of bipolar disorder. Pharmacogenetics and Genomics (Accepted for publication)


McHugh, P.M., Rogers, G.R., Glubb, D.M., Allington, M., Joyce, P.R., Kennedy, M.A. (2008) Proteomic analysis of rat hippocampus exposed to the antidepressant paroxetine. J. Psychopharmacol. (In Press)

Stamp, L.K., O’Donnell, J.L., Chapman, P/T., Barclay, M.L., Kennedy, M.A., Frampton, C.M.A., Roberts, R.L. (2008) Lack of association between HLA-G 14bp in-del polymorphism and response to long-term therapy with methotrexate response in rheumatoid arthritis. Annals of the Rheumatic Diseases 68, 154-5

McHugh, P.M., Rogers,G.M., Glubb, D.M., Allington, M.D., Hughes, M., Joyce, P.R., and Kennedy, M.A. (2008) Downregulation of Cyclin D1 (Ccnd1) and Hairy Enhancer of Split 6 (Hes6) in rat hippocampus after chronic exposure to the antidepressant paroxetine. Acta Neuropsychiatrica 20, 307-313

Roberts RL, Hollis-Moffatt JE, Gearry RB, Kennedy MA, Barclay ML, Merriman TR. (2008) Confirmation of association of NCF4 and IRGM with ileal Crohn’s disease in a population-based cohort. Genes & Immunity 9, 561-5

Clark, DWJ, Ashton, JA, Wallace, AK, Zhou, L, Kennedy, MA. (2008) Pharmacogenetic investigation using a pharmacovigilance database. PharmacoVigilance Review 2, 9-13.

Roberts, R.L., Gearry, R.B., Kennedy, M.A., Barclay, M.L. (2008) Beyond TPMT: genetic influences on thiopurine drug responses in inflammatory bowel disease. Personalized Medicine 5, 233-248.

Lea RA, Roberts RL, Green MR, Chambers GK, Kennedy MA. (2008) Allele Frequency Differences of Cytochrome P450 Polymorphisms in New Zealand Maori. NZ Med J 121, 33-37

Bentley, R.W., Keenan, J.I., Gearry, R.B., Kennedy, M.A., Barclay, M.L., Roberts, R.L. (2008) Incidence of Mycobacterium avium Subspecies paratuberculosis in a Population-Based Cohort of Patients With Crohn's Disease and Control Subjects. American Journal of Gastroenterology 103, 1168-1172.

Porter, R.L., Mulder, R.T., Joyce, P.R., Miller, A.L., Kennedy, M.A. (2008) Tryptophan hydroxylase gene (TPH1) and peripheral tryptophan levels in depression. J Affect Disorders 109, 209-212.

Roberts, R.L, Gearry, R., Sies, C., George, P., Burt, M., Marinaki, A., Barclay, M., Kennedy, M.A. (2008). Trinucleotide repeat variants in the promoter of the thiopurine S-methyltransferase gene of patients exhibiting ultra-high enzyme activity. Pharmacogenetics and Genomics 18, 434-438.

McHugh, P.M., Rogers, G.R., Loudon, B., Glubb, D.G., Joyce, P.R., Kennedy, M.A. (2008) Proteomic analysis of embryonic stem cell-derived neural cells exposed to the antidepressant paroxetine. Journal of Neuroscience Research 86, 306-316.

Littlejohn, M.D., Palmer, B.R. Pilbrow. A., Richards, A.M., Frampton, C.M., Troughton, R.W., Cameron, A.V, Kennedy, M.A. (2008) Ile164 variant of beta 2-adrenoceptor does not influence outcome in congestive heart failure but may interact with beta-blocker treatment. European Journal of Heart Failure 10, 55-59.

Stuffrein-Roberts, S., Joyce, P.R., Kennedy, M.A. (2008) Role of epigenetics in mental disorders. ANZ Journal of Psychiatry 42, 97-107.


Roberts RL, Gearry RB, Hollis-Moffatt JE, Miller AL, Reid J, Abkevich V, Timms KM, Gutin A, Lanchbury JS, Merriman TR, Barclay ML, Kennedy MA. (2007). IL23R R381Q and ATG16L1 T300A are strongly associated with Crohn’s disease in a study of New Zealand Caucasians with inflammatory bowel disease. American Journal of Gastroenterology. 102, 1-8.

Johnstone, A., Brennan, K., Schenk, S., Kennedy, M., Lea, R., Fitzmaurice, P. (2007). Benzylpiperazine (BZP) a recreational drug of abuse? Current knowledge and future direction. J. Psychopharmacology 21, 888-94.

Gearry, RB, Roberts, RL, Burt, MJ, Frampton, CMA, Chapman, BA, Collett, JA, Shirley, P, Allington, MDE, Kennedy, MA, Barclay, ML. (2007) Effect of inflammatory bowel disease classification changes on NOD2 genotype-phenotype associations in a population-based cohort. Inflammatory Bowel Diseases 13 (10): 1220-1227.

Joyce, P.R., Light, K.J., Rowe, S., Kennedy, M.A. (2007) Bipolar disorder NOS: a comparison with bipolar disorder I/II and major depression. ANZ Journal of Psychiatry 41, 843-849.

Light K J, Miller A L, Doughty C J, Joyce P R, Olds, R J, Kennedy M A (2007) FAT and Bipolar Affective Disorder. Molecular Psychiatry 12, 899-900.

Roberts, R.L., Gearry, R.B., Barclay, M.L., Kennedy, M.A. (2007) IMPDH1 promoter mutations in a patient exhibiting azathioprine resistance. Pharmacogenomics J. 7, 312-317.

Beaglehole, B., Luty, S.E., Mulder, R.T., Kennedy, M.A., Joyce, P.R. (2007) Low red cell folate levels are associated with response to nortriptyline in major depression. Acta Neuropsychiatrica 19, 204-207.

Kennedy, M.A. (2007) Pharmacogenomics: single genes, whole genomes and global networks. Personalized Medicine 4, 87-94.

Light, K.J., Joyce, P.R., Luty, S.E., Mulder, R.T., Carter, J.D., Frampton, C.M.A., Miller, A.L., Kennedy, M.A. (2007) An association study of DRD2 and COMT polymorphisms with novelty seeking and harm avoidance scores, in two independent samples of depressed patients. Behavioral and Brain Functions 3, 1-6.


Stamp, L., Roberts, R., Kennedy, M., Barclay, M., O’Donnell, J., Chapman, P. (2006) The use of low dose methotrexate in rheumatoid arthritis – are we entering a new era of therapeutic drug monitoring and pharmacogenomics? Biomedicine and Pharmacotherapy 60, 678-87.

Light, K., Joyce P.R., Luty, S., Mulder, R., Frampton, C., Joyce, L., Miller, A.L., Kennedy, M.A. (2006). Preliminary evidence for an association between a dopamine D3 receptor gene variant and obsessive-compulsive personality disorder in patients with major depression American J. Medical Genet. 141B:409–413.

Joyce, P. R., McHugh, P. C., McKenzie, J. M., Sullivan, P. F., Mulder, R. T., Luty, S. E., Carter, J. D., Frampton, C. M. A., Cloninger, C. R., Miller, A. M. & Kennedy, M. A. (2006) A dopamine transporter polymorphism is a risk factor for borderline personality disorder in depressed patients. Psychological Medicine. 36, 807-814.

Gearry, R.B., Lea, R.A., Roberts, R.L., Chambers, G.K., Barclay, M.L., Kennedy, M.A. (2006) CARD15 allele frequency differences in New Zealand Maori: ancestry-specific susceptibility to Crohn's disease in New Zealand? Gut 55, 580.

Roberts, R.L., Kennedy, M.A. (2006) Rapid detection of common Cytochrome P450 2D6 alleles in Caucasians. Clinica Chimica Acta 366, 348 - 351.

Joyce P.R., McKenzie J.M., Mulder R.T., Luty S.E., Sullivan P.F., Miller A.L., Kennedy M.A. (2006) Genetic, developmental and personality correlates of self mutilation in depressed patients. ANZ. J. Psychiatry 40, 225–229.


Taylor, D.R., Epton, M., Kennedy, M.A., Smith, A.D., Isles, S., Miller, A.L., Littlejohn, M.D., Cowan, J.O., Hewitt, T., Swanney, M.P., Brassett, K.P., Herbison, G.P. (2005) Bronchodilator response in relation to beta-adrenoceptor haplotype in patients with asthma.. Amer. J. Resp. Crit. Care Med. 172, 700-703.

Kennedy MA, Roberts RL, Joyce PR (2005) Re: No evidence of increased adverse drug reactions in cytochrome P450CYP2D6 poor metabolizers treated with fluoxetine or nortriptyline - Authors' response. Hum Psychopharmacol Clin Exp 20 (1): 63-64.

Joyce, P. R., Porter, R. J., Mulder, R. T., Luty, S. E., McKenzie, J. M., Miller, A. L., and Kennedy, M. A. (2005). Reversed diurnal variation in depression: associations with a differential antidepressant response, tryptophan: large neutral amino acid ratio and serotonin transporter polymorphisms. Psychol Med 35, 511-517.


Gearry, R.B., Roberts, R.L., Barclay, M.L., Kennedy, M.A. (2004) Lack of association between the ITPA 94C>A polymorphism and adverse effects from azathioprine. Pharmacogenetics 14, 779-781.

Clark, D.W.J., Donnelly, E., Coulter, D.M., Roberts, R.L., Kennedy, M.A. (2004) Linking Pharmacovigilance with Pharmacogenetics. Drug Safety 27(15) 1171-1184.

Roberts, R.L., Gearry, R.B, Barclay, M.L., Kennedy, M.A. (2004) Rapid detection of common CARD15 variants in patients with inflammatory bowel disease. Molecular Diagnosis 8(2) 101-105.

Roberts, R.L., Luty, S.E., Mulder, R.L., Joyce, P.R., Kennedy, M.A.. (2004) Association between Cytochrome P450 2D6 genotype and Harm Avoidance. Amer. J Med. Genet. 127B:90-93.

Rogers, G., Joyce, P., Mulder, R., Sellman, D., Miller, A., Allington, M., Olds, R., Wells, E., Kennedy, M. (2004) Association of a duplicated repeat polymorphism in the 5'-untranslated region of the DRD4 gene with novelty seeking. Amer. J. Med. Genet. 126B:95-98.

Roberts, R.L., Barclay, M.L., Gearry, R., Kennedy, M.A. (2004). A multiplexed allele-specific polymerase chain reaction assay for the detection of common thiopurine methyltransferase (TPMT) mutations. Clinica Chimica Acta 341, 49-53.

Roberts, R.L., Mulder, R.T., Joyce, P.R., Luty, S.E., Kennedy, M.A. (2004) No evidence of increased side effects in cytochrome P450 2D6 poor metabolisers treated with either fluoxetine or nortriptyline. Hum Psychopharmacol Clin Exp 19, 17–23.


Joyce, P.R., Mulder, R.T., Luty, S.E., McKenzie, J.M., Miller, A.L., Rogers, G.R., Kennedy, M.A. (2003) Age dependent antidepressant pharmacogenomics: polymorphisms of the serotonin transporter and G protein ?3 subunit as predictors of response to fluoxetine and nortriptyline. Int. J. Neuropsychopharm. 6, 339 – 346.

Barclay, M.L., Sawyer, S.M., Begg, E.J., Zhang, M., Roberts, R.L., Kennedy, M.A., Elliot, J. (2003) Correlation of CYP450 2D6 genotype with perhexiline phenotypic metabolizer status. Pharmacogenetics 13, 627-632.

Gearry RB, Barclay ML, Burt MJ, Collett JA, Chapman BA, Roberts RL, Kennedy MA. (2003) Thiopurine S-methyltransferase (TPMT) genotype does not predict adverse drug reactions to thiopurine drugs in patients with inflammatory bowel disease. Aliment Pharmacol Ther 18, 395-400.

Joyce, P.R., Rogers, G.R., Miller, A.L., Mulder, R.T., Luty, S.E., Kennedy, M.A. (2003). Polymorphisms of DRD4 and DRD3 and risk of avoidant and obsessive personality traits and disorders. Psychiatry Res. 119, 1-10.

Sundram, S., Joyce, P.R., Kennedy, M.A. (2003) The nature and neurobiology of schizophrenia and bipolar affective disorder. Current Molecular Medicine 3, 393-407.


Littlejohn, M.L., Taylor, D.R., Miller, A.M., Kennedy, M.A. (2002) Determination of ?2-adrenergic receptor haplotypes by a multiplexed polymerase chain reaction assay. Human Mutation 20, 479-479, Mutation in Brief #562 Online.

Roberts, R.L., Joyce, P.R., Mulder, R.T., Begg, E.J., Kennedy, M.A. (2002) A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression. Pharmacogenomics Journal 2, 191-196.

Stedman, C.A.M., Begg, E., Kennedy, M.A., Roberts, R., Wilkinson, T.J. (2002) Cytochrome P450 2D6 genotype does not predict SSRI (fluoxetine or paroxetine) induced hyponatraemia. Hum Psychopharmacol Clin Exp 2002 17, 187–190.

Wood, J.G., Joyce, P.R., Miller, A.L., Mulder, R.T., Kennedy, M.A. (2002) A polymorphism in the dopamine ?-hydroxylase gene is associated with “paranoid ideation” in patients with major depression. Biological Psychiatry 51, 365-369.

Roberts, R.L., Begg, E.J., Joyce, P.R., Kennedy, M.A. (2002). How the pharmacogenetics of cytochrome P450 enzymes may affect prescribing. NZ Med. J 115, 137-140.

Ferguson, G.C., Heinemann, J.A., Kennedy, M.A. (2002) Gene transfer between Salmonella enterica Serovar Typhimurium inside epithelial cells. J. Bacteriology 184, 2235-2242.

Taylor, D.R., Kennedy, M.A. (2002) Beta-adrenergic receptor polymorphisms and drug responses in asthmatics. Pharmacogenomics 3, 173-184.


Taylor, D.R., Kennedy, M.A. (2001) Genetic variation of the ?2 adrenoceptor: its functional and clinical importance in bronchial asthma. Amer. J. Pharmacogenomics 1, 165-174.

Martin, J.H., Begg, E.J., Kennedy, M.A., Roberts, R., Barclay, M.L. (2001) Is cytochrome P450 2C9 genotype associated with NSAID gastric ulceration? Brit J Clin Pharm 51, 627-630.

Kennedy, M.A. (2001). What does the human genome project mean for medicine? NZ Med J 114, 190-192.


Roberts, R., Sullivan, P., Joyce, P., Kennedy, M.A. (2000). Rapid and comprehensive determination of cytochrome P450 CYP2D6 poor metabolizer genotypes by multiplex polymerase chain reaction. Human Mutation. 16, 77-85.


Hanrahan, V., George, P.M., Kennedy, M. (1999). Instability characteristics of trinucleotide (CAG) repeat tracts in Escherichia coli. J. Biochem. Molec. Biol. Biophys. 3, 117-125.


Sullivan, P.F., Fifield, W.J., Kennedy, M.A., Mulder, R.T., Sellman, J.D., Joyce, P.R. (1998). No association between novelty seeking and the type 4 dopamine receptor (DRD4) in two New Zealand samples. American Journal of Psychiatry 155, 98-101.


Sullivan PF, Fifield WJ, Kennedy MA, Mulder RT, Sellman JD, Joyce PR. (1997). Novelty seeking and a dopamine transporter gene polymorphism (DAT1). Biological Psychiatry 42, 1070-1072.

Dodd, A., Rowland, S.A., Hawkes, S.L.J., Kennedy, M.A., Love, D.R. (1997). Mutations in the adrenoleukodystrophy gene. Human Mutation. 9, 500-511.


Rowland SA., Dodd, A., Roche, AL., Manilal, S., Kennedy, MA., Becroft, DMO., Tonkin, S., Chapman, C., and Love, DR.(1996) DNA-based diagnostics for adrenoleukodystrophy in a large New Zealand family. NZ Med. J. 109, 312-315.

Cameron, V.A., Aitken, G.D., Ellmers, L.J., Kennedy, M.A., Espiner, E.A. (1996). The sites of gene expression of Atrial, Brain and C-type natriuretic peptides in mouse fetal development: temporal changes in embryos and placenta. Endocrinology 137, 817-824.

Kennedy, M.A., Rowland, S., Miller, A.L., Morris, C.M., Neville, L.A., Dodd, A., Fifield, W.J., Love, D.R. (1996) Structure and location of the murine adrenoleukodystrophy gene. Genomics 32, 395-400.

Morris, C., Jeffs, A., Smith, T., McDonald, M., Board, P., Kennedy, M., Fitzgerald, P. (1996) BCR gene recombines with genomically distinct sites on band 11q13 in complex BCR-ABL translocations of chronic myeloid leukemia. Oncogene 12, 677-685.


Neville, L., Cochrane, J., Fitzgerald, P., Kennedy, M. (1995). Fragile X mental retardation syndrome: DNA diagnosis and carrier detection in New Zealand families. NZ Med. J. 108, 190-192.


Kennedy, M.A., Rayner, J.C., Morris, C.M. (1994). Genomic structure, promoter sequence and revised translation of human homeobox gene HLX1. Genomics 22, 348-355.

Sander, A., Kennedy, M..A., Rayner, J.C., Murray, J.C. (1994). Dinucleotide repeat polymorphism for HLX1gene. Hum. Mol. Gen. 3, 219.


Crossen, P.E., Kennedy, M.A., Heaton, D.C., Morrison, M.J. (1993) Cloning and sequencing of a t(14;19) breakpoint that involves the Cu switch region. Genes Chrom. Cancer 8, 60-62.

Sowerby, S., Kennedy, M.A., Fitzgerald, P.H., Morris, C.M. (1993). DNA sequence analysis of the major breakpoint cluster region of the BCR gene rearranged in Philadelphia positive human leukemia. Oncogene 8, 1679-1683.


Morris, C.M., Kennedy, M.A., Heisterkamp, N., Columbano-Green, L., Romeril, K., Groffen, J., Fitzgerald, P. (1991). A complex chromosome rearrangement forms the BCR-ABL fusion gene in leukemic cells with a normal karyotype. Genes Chrom. Cancer 3, 263-271.

Kennedy, M.A., Gonzales-Sarmiento, R., Kees, U.R., Lampert, F., Dear, N., Boehm, T. Rabbitts, T.H. (1991). HOX-11, a homeobox-containing T-cell oncogene on human chromosome 10q24. Proc. Natl. Acad. Sci. USA. 88, 8900-8904.

Kennedy, M.A. (1991). Novel chromosome translocation caused by fusion of immunoglobulin heavy and light chain V genes in a human B-lymphoblastoid cell line. J. Exp. Med. 173, 1033-1036.

Boehm, T., Gonzales-Sarmiento, R., Kennedy, M.A., Rabbitts, T.H. (1991). A simple technique for generating probes for RNA in situ hybridization: an adjunct to genome mapping exemplified by the RAG-1/RAG-2 gene cluster. Proc. Natl. Acad. Sci. USA. 88, 3927-3931.


Morris, C.M., Heisterkamp, N., Kennedy, M.A., Fitzgerald, P.H., Groffen, J. (1990). Ph-negative chronic myeloid leukemia: molecular analysis of ABL insertion into M-BCR on chromosome 22. Blood 76, 1812-1818.

Boehm, T., Foroni, L., Kennedy, M.A., Rabbitts, T.H. (1990). The rhombotin gene belongs to a class of transcriptional regulators with a potential novel protein dimerisation motif. Oncogene 5, 1103-1105.


Morris, C.M., Fitzgerald P.H., Kennedy, M.A., Hollings, P.E., Garry, M., Corbett, G.M. (1989). HRAS1 and INS genes are relocated but not structurally altered as a result of the t(7;11)(p15;p15) in a clone from a patient with acute myeloid leukemia (M4). Brit. J. Haematology 71, 481-486.

Kennedy, M.A., Morris, C.M., Hollings, P.E., Fitzgerald, P.H. (1989). Involvement of immunoglobulin heavy- and light- chain (k) gene clusters in a human B-cell translocation, t(2;14). Cytogen. Cell Genet. 52, 50-56.

Kennedy, M.A., Morris, C.M., Fitzgerald, P.H. (1989). A sequence homologous to kappa-deleting element is located 5' to the human Jk locus. Nucl. Acids Res. 17, 809.

Kennedy, M.A., Morris, C.M., Fitzgerald, P.H. (1989). The oncogene ETS1 is distant from the chromosome 11 breakpoint in leukemic cells with the t(11;19)(q23;p13). Leukemia Res. 13, 459-463.

Kennedy, M.A., Crossen, P.E. (1989). Nucleotide sequence of an immunoglobulin-D immunoglobulin-J gene fusion from a B-cell prolymphocytic leukaemia. Nucl. Acids Res. 17, 4879.

Bodger, M.P., Morris, C.M., Kennedy, M.A., Bowen, J.A., Hilton, J.M., Fitzgerald, P.H. (1989). Basophils (Bsp-1+) derive from the leukemic clone in human myeloid leukemias involving the chromosome breakpoint 9q34. Blood 73, 777-781.


Kennedy, M.A., Lane, D., Chandler, M. (1988). Mapping and regulation of the pifC promoter of the F plasmid. Biochim. Biophys. Acta 90, 75-80.

Bosma, TJ., Kennedy, M.A., Bodger, M., Hollings, P., Fitzgerald, P. (1988). Basophils exhibit rearrangement of the bcr gene in Philadelphia chromosome positive chronic myeloid leukemia. Leukemia 2, 141-143.


Lane, D., DeFeyter, R., Kennedy, M., Phua, S.H., Semon, D. (1986). D protein of mini-F plasmid acts as a repressor of transcription and as a site-specific resolvase. Nucl. Acids Res. 14, 9713-9728.