File:Folate mediate endocytosis.jpg

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Receptor-mediated endocytosis of a drug conjugated to folate. (1) The drug–folate conjugate binds to folate receptors in caveolae. (2) Membrane invagination occurs and the drug–folate conjugate is engulfed by the cell and internalized by the endocytotic pathway. (3) Drug release is initiated by the low pH environment of the endosome. (4) Drug and imaging agents are released into the cell. (5) The folate receptor can be recycled and returned to the cell membrane. (Illustrated by Samantha L. Lindberg).

Reference: Utilizing the folate receptor for active targeting of cancer nanotherapeutics | Zwicke | Nano Reviews. (n.d.). Retrieved from http://www.nano-reviews.net/index.php/nano/article/view/18496/25003

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current02:12, 25 October 2014Thumbnail for version as of 02:12, 25 October 2014415 × 431 (166 KB)Jonathan Chan (talk | contribs)Receptor-mediated endocytosis of a drug conjugated to folate. (1) The drug–folate conjugate binds to folate receptors in caveolae. (2) Membrane invagination occurs and the drug–folate conjugate is engulfed by the cell and internalized by the endocytot
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