File:Fgene-04-00018-g0001.jpg
Fgene-04-00018-g0001.jpg (669 × 501 pixels, file size: 129 KB, MIME type: image/jpeg)
Right column: The A:8-oxo-G base pairs can be recognized by MUTYH, which catalyzes the excision of the wrong A from opposite 8-oxo-G, leading to the formation of an AP site. This AP site is further processed by APE1, which results in a 1 nt gap with 3′OH and 5′dRP moieties. The incorporation of the correct C opposite 8-oxo-G and one more nucleotide is performed by pol λ in collaboration with the cofactors PCNA and RP-A, thus performing strand displacement of the downstream DNA strand. FEN1 cleaves the 5′ flap, leading to a 5′P moiety, which can be ligated by DNA ligase I to yield an intact C:8-oxo-G containing double-stranded DNA. This C:8-oxo-G is then again substrate for OGG1-mediated removal of 8-oxo-G (left column).
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 11:35, 28 March 2013 | | 669 × 501 (129 KB) | Alesha Stewart (talk | contribs) | Enni Markkanen, Julia Dorn, and Ulrich Hübscher. MUTYH DNA glycosylase: the rationale for removing undamaged bases from the DNA. Front Genet. 2013; 4: 18. Right column: The A:8-oxo-G base pairs can be recognized by MUTYH, which catalyzes the excision of |
| 11:33, 28 March 2013 |  | 669 × 501 (129 KB) | Alesha Stewart (talk | contribs) | Right column: The A:8-oxo-G base pairs can be recognized by MUTYH, which catalyzes the excision of the wrong A from opposite 8-oxo-G, leading to the formation of an AP site. This AP site is further processed by APE1, which results in a 1 nt gap with 3′O |
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