File:Alkylating agent.gif

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Mechanisms of traditional chemotherapy. These drugs act on rapidly dividing cells, which include normal tissues (e.g., hair, gastrointestinal epithelium, bone marrow) in addition to cancer cells. Alkylating agents interfere with DNA base pairing, leading to strand breaks and arresting DNA replication. Topoisomerase inhibitors prevent DNA uncoiling. Taxanes and vinca alkaloids interfere with micro-tubule function required for cell mitosis. Antimetabolites block the formation and use of nucleic acids essential for DNA replication.

Reference:DAVID E. GERBER, MD, University of Texas Southwestern Medical Center, Dallas, Texas Am Fam Physician. 2008 Feb 1;77(3):311-319.

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current01:53, 25 October 2014Thumbnail for version as of 01:53, 25 October 2014410 × 339 (31 KB)Jonathan Chan (talk | contribs)Mechanisms of traditional chemotherapy. These drugs act on rapidly dividing cells, which include normal tissues (e.g., hair, gastrointestinal epithelium, bone marrow) in addition to cancer cells. Alkylating agents interfere with DNA base pairing, leading
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