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CSBi.100 class with Drew Endy

Friday, November 4, 2005


  1. Global transposon mutagenesis and a minimal Mycoplasma genome, Hutchison et al. URL
  2. Refactoring bacteriophage T7, Chan et al. URL
  3. Combining two genomes into one cell, Itaya et al. URL
  4. Adventures in Synthetic Biology (comic strip, to be made available the week of class)

Seed Questions

  1. Is there a difference between a "modelable" genome, and a "minimal" genome? What about a "modular" organism?
  2. Do we know enough about the parts of biological systems to put things back together?
  3. Is there a difference between "constructing" something, versus "creating" something?
  4. Is it easier, better, faster (etc) to understand something by tearing it apart? Or, by putting it back together?
  5. <add your question here!>