Inventory of different kind of building blocks required.
If we want our system to be as modular as possible we'll have to use very efficient adaptor domains. For example, we can couple a unique "writer domain" to multiple targeting domains.
- Leucine zippers
- PDZ domains
(note: check for Kd etc...)
We will probably have to target enzymes to specific DNA sites for example or proteins to specific localizations.
- DNA targetting domain
zinc-finger other DNA binding domains
- Localization domains
Nuclear localization signals
Nuclear export sequences