BME100 s2014:T Group7 L2
Lab 2: Adding to the Toolbox: Using Statistics
Data Descriptive Statistics
According to the data, the effect of LPS in rats does not show a significant change in Inflammotin levels.
The human LPS trials showed significant differences in Inflammotin levels between dosage groups.
Summary and Conclusions
From the experiments performed, LPS has shown to have a noticeable effect in Inflammotin levels in humans but not in rats.
In the rat experiment, the LPS group showed no appreciable increase in Inflammotin levels. Ten rats were tested; five rats were given 0 mg of LPS while five rats were given a 10 mg dose of LPS. Though there were differences in Inflammotin levels between groups, none were significant enough (according to ANOVA and t-tests performed) to suggest that the LPS was the cause.
In the human experiment, the LPS showed to have an effect on Inflammotin levels. Forty elderly human subjects were tested separated into four groups, each receiving a different dose of LPS. Doses given were 0, 5, 10, and 15 mg. The levels of Inflammotin in each group increased substantially as the dosage increased. Statistical analysis (according to ANOVA and t-tests performed) showed a significant difference in Inflammotin levels between each dose group.
Though there were obvious observed differences between the human and rat experiments, the number of rat volunteers in the experiment was far less than the number of human subjects. This could have skewed the results, given the high variance between Inflammotin levels among rat groups. Were this experiment performed with similar numbers of subjects between species, the difference in effects of LPS between humans and rats could be more accurately observed.