From OpenWetWare
Jump to: navigation, search

<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" ""> <html xmlns="" xmlns:v="urn:schemas-microsoft-com:vml" xml:lang="en" lang="en" dir="ltr"> <head> <meta http-equiv="Content-Type" content="text/html; charset=utf-8" /> <meta name="generator" content="MediaWiki 1.13.2" /> <meta name="keywords" content="Biomod/2013/Todai" /> <link rel="shortcut icon" href="/favicon.ico" /> <link rel="apple-touch-icon" href="/OWWIPhone.png" /> <link rel="search" type="application/opensearchdescription+xml" href="/opensearch_desc.php" title="OpenWetWare (en)" /> <link title="Creative Commons" type="application/rdf+xml" href="/index.php?title=Biomod/2013/Todai&action=creativecommons" rel="meta" /> <link title="Dublin Core" type="application/rdf+xml" href="/index.php?title=Biomod/2013/Todai&action=dublincore" rel="alternate meta" /> <link rel="copyright" href="/wiki/Copyright" /> <link rel="alternate" type="application/rss+xml" title="OpenWetWare RSS Feed" href="" /> <link rel="alternate" type="application/atom+xml" title="OpenWetWare Atom Feed" href="" /> <title>Biomod/2013/Todai - OpenWetWare</title> <style type="text/css" media="screen, projection">/*<![CDATA[*/ @import "/skins/common/shared.css?164"; @import "/skins/monobook/main.css?164"; /*]]>*/</style> <link rel="stylesheet" type="text/css" media="print" href="/skins/common/commonPrint.css?164" />

<script type= "text/javascript">/*<![CDATA[*/ var skin = "monobook"; var stylepath = "/skins"; var wgArticlePath = "/wiki/$1"; var wgScriptPath = ""; var wgScript = "/index.php"; var wgVariantArticlePath = false; var wgActionPaths = []; var wgServer = ""; var wgCanonicalNamespace = ""; var wgCanonicalSpecialPageName = false; var wgNamespaceNumber = 0; var wgPageName = "Biomod/2013/Todai"; var wgTitle = "Biomod/2013/Todai"; var wgAction = "view"; var wgArticleId = "134960"; var wgIsArticle = true; var wgUserName = "Kenta Koyama"; var wgUserGroups = ["*", "user", "autoconfirmed"]; var wgUserLanguage = "en"; var wgContentLanguage = "en"; var wgBreakFrames = false; var wgCurRevisionId = "722090"; var wgVersion = "1.13.2"; var wgEnableAPI = true; var wgEnableWriteAPI = false; var wgMWSuggestTemplate = "\x26search={searchTerms}\x26namespace={namespaces}"; var wgDBname = "owwdb"; var wgSearchNamespaces = [0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 100, 101, 110, 111]; var wgMWSuggestMessages = ["with suggestions", "no suggestions"]; var wgRestrictionEdit = []; var wgRestrictionMove = []; var wgAjaxWatch = {"watchMsg": "Watch", "unwatchMsg": "Unwatch", "watchingMsg": "Watching...", "unwatchingMsg": "Unwatching..."}; /*]]>*/</script>

<script type="text/javascript" src="/skins/common/wikibits.js?164"></script> <script type="text/javascript" src="/skins/common/ajax.js?164"></script> <script type="text/javascript" src="/ext/AjaxShowEditors/AjaxShowEditors.js"></script> <script type="text/javascript" src="/skins/common/ajaxwatch.js?164"></script> <script type="text/javascript" src="/skins/common/mwsuggest.js?164"></script> <script type="text/javascript" src="/index.php?title=-&action=raw&smaxage=0&gen=js&useskin=monobook"></script> <style type="text/css">/*<![CDATA[*/ @import "/index.php?title=MediaWiki:Common.css&usemsgcache=yes&action=raw&ctype=text/css&smaxage=18000"; @import "/index.php?title=MediaWiki:Monobook.css&usemsgcache=yes&action=raw&ctype=text/css&smaxage=18000"; @import "/index.php?title=-&action=raw&gen=css&maxage=18000&smaxage=0&ts=20131025152621&useskin=monobook"; @import "/index.php?title=User:Kenta_Koyama/monobook.css&action=raw&ctype=text/css"; /*]]>*/</style> <script type="text/javascript" src="/index.php?title=User:Kenta_Koyama/monobook.js&action=raw&ctype=text/javascript"></script> </head> <body class="mediawiki ns-0 ltr page-Biomod_2013_Todai">

<a name="top" id="top"></a>


From OpenWetWare

< <a href="/wiki/Biomod" title="Biomod">Biomod</a> | <a href="/wiki/Biomod/2013" title="Biomod/2013">2013</a>
Jump to: <a href="#column-one">navigation</a>, <a href="#searchInput">search</a>

<head> <meta name="viewport" content="width=1200"> <style> </style> </head> <body>



<head> <style>

.to-project a{


</style> </head>


<a name="Home"> Home</a>



<a name="Oligomeric Cell Killer"> Oligomeric Cell Killer</a>

<p class="paragraph">Team Todai nanORFEVRE tried to make cancer-specific pore-forming DNA origami drug.

We named this DNA nanostructure "Oligomeric Cell Killer".


<a name="Abstract"> Abstract</a>

  <img src="" width="450px" height="350px" >

Cancer is one of the most common diseases in the world. Chemotherapy is a popular treatment for cancer, however, it attacks normal cells in addition to cancer cells, causing severe side effects in some cases. Recently drug delivery system (DDS) has developed to improve cancer-specificity, but it is difficult to optimize delivery system for each drug.


Here, we tried to make a prototype of oligomeric cancer specific pore-forming DNA origami, termed Oligomeric Cell Killer (OCK), which might be a side effects free anti-cancer drug.


OCKs exist in a monomeric form in solution and penetrate into the cell randomly. Cancer specific molecules on the membrane of cancer cell trigger the oligomerization of OCK, resulting in the pore-forming and subsequent death of cancer cell. In contrast, the OCKs keep monomeric form in the normal cell, allowing the normal cell to keep alive. Our study might be the basis for cancer specific drug.


    <a href="">
    >>To Project<<

<footer style="position:relative;left:400px"> Copyright © Todai nanORFEVRE, all rights reserved. </footer> </body>


  • <a href="/wiki/Biomod/2013/Todai" title="View the content page [c]" accesskey="c">Page</a>
  • <a href="/index.php?title=Talk:Biomod/2013/Todai&action=edit" title="Discussion about the content page [t]" accesskey="t">Talk</a>
  • <a href="/index.php?title=Biomod/2013/Todai&action=edit" title="You can edit this page. Please use the preview button before saving. [e]" accesskey="e">Edit</a>
  • <a href="/index.php?title=Biomod/2013/Todai&action=history" title="Past versions of this page. [h]" accesskey="h">History</a>
  • <a href="/wiki/Special:MovePage/Biomod/2013/Todai" title="Move this page [m]" accesskey="m">Move</a>
  • <a href="/index.php?title=Biomod/2013/Todai&action=unwatch" title="Remove this page from your watchlist [w]" accesskey="w">Unwatch</a>
Personal tools
  • <a href="/wiki/User:Kenta_Koyama" title="My user page [.]" accesskey=".">Kenta Koyama</a>
  • <a href="/wiki/User_talk:Kenta_Koyama" title="My talk page [n]" accesskey="n">My talk</a>
  • <a href="/wiki/Special:Preferences" title="My preferences">My preferences</a>
  • <a href="/wiki/Special:Watchlist" title="The list of pages you're monitoring for changes [l]" accesskey="l">My watchlist</a>
  • <a href="/wiki/Special:Contributions/Kenta_Koyama" title="List of my contributions [y]" accesskey="y">My contributions</a>
  • <a href="/index.php?title=Special:UserLogout&returnto=Biomod/2013/Todai" title="Log out">Log out</a>

<script type="text/javascript">if (window.runOnloadHook) runOnloadHook();</script>

<script src="/js/Urchin/urchin.js" type="text/javascript"> </script> <script type="text/javascript"> _uacct = "UA-2860391-2"; urchinTracker(); </script>