BE.109/WFBlue

Module 4 Research Proposal

Injectisome is a protein that is found on some bacteria that acts as a needle. Because of this, bacteria wit this protein can act like bacteriophage, and can even inject matterial into mammalian cells. This protein is thoought to fuction as a conduit for protein translocation.

Research Idea

Our research idea uses this protein to create a new drug delivery system. Using the idea of systems engineering and synthetic biology, we could create a new part that produces this injectisome protein. We could then use this part to create a cell that could produce and inject a protein. Our idea is to study how this protein works, and test its effectiveness on mammalian cells.

References

[1] Bacterial Injectisomes: Needle Length Does Matter